BGC0001822: vioprolide A biosynthetic gene cluster from Cystobacter sp.
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Location: 1 - 44,663 nt. (total: 44,663 nt).
This entry is originally from NCBI GenBank MH108942.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001822
Short description vioprolide A biosynthetic gene cluster from Cystobacter sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MH108942.1
via
Compounds
  • vioprolide A
  • vioprolide B
  • vioprolide C
  • vioprolide D
Species Cystobacter sp. [taxonomy]
References
Chemical products information
vioprolide A Evidence:
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C40H62N8O11S1
Chemical database entries
PubCHEM
vioprolide B Evidence:
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C40H62N8O11S1
Chemical database entries
PubCHEM
vioprolide C Evidence:
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C39H60N8O11S1
Chemical database entries
PubCHEM
vioprolide D Evidence:
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C39H60N8O11S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AWI62625.1
  • vioL
 185 - 1321 (+) lysine cyclodeaminase
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    • AWI62626.1
    • vioA
    		 1321 - 16062 (+) nonribosomal peptide synthetase
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      • AWI62627.1
      • vioB
      		 16083 - 22562 (+) nonribosomal peptide synthetase
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        • AWI62628.1
        • vioC
        		 22559 - 32521 (+) nonribosomal peptide synthetase
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          • AWI62629.1
          • vioD
          		 32518 - 37905 (+) nonribosomal peptide synthetase
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            • AWI62630.1
            • vioE
            		 37902 - 39704 (+) hypothetical protein
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              • AWI62631.1
              • vioF
              		 39719 - 41050 (+) hypothetical protein
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                • AWI62632.1
                • vioG
                		 41130 - 42782 (+) hypothetical protein
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                  • AWI62633.1
                  • vioH
                  		 42779 - 43492 (+) hypothetical protein
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                    • AWI62634.1
                    • vioI
                    		 43564 - 43854 (+) hypothetical protein
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                      • AWI62635.1
                      • vioJ
                      		 43892 - 44182 (+) hypothetical protein
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                        • AWI62636.1
                        • vioK
                        		 44290 - 44502 (+) MbtH-like domain-containing protein
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          Unk01
                          Type
                          nrps-type1
                          Genes
                          vioA
                          Substrates
                          alanine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk02
                          Type
                          nrps-type1
                          Genes
                          vioA
                          Substrates
                          leucine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk03
                          Type
                          nrps-type1
                          Genes
                          vioB
                          Substrates
                          proline (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk04
                          Type
                          nrps-type1
                          Genes
                          vioB
                          Substrates
                          cysteine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk05
                          Type
                          nrps-type1
                          Genes
                          vioC
                          Substrates
                          threonine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk06
                          Type
                          nrps-type1
                          Genes
                          vioC
                          Substrates
                          pipecolic acid (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk07
                          Type
                          nrps-type1
                          Genes
                          vioC
                          Substrates
                          threonine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk08
                          Type
                          nrps-type1
                          Genes
                          vioD
                          Substrates
                          valine (evidence: Structure-based inference, Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          adenylation
                          Annotation changelog

                          Entry version: next

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2024-07-24
                          MIBiG v4 annotathon
                          • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Fetched compound information from PubChem
                          • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Added NRP substrate specificities
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2019-10-16
                          Updated compound(s) information (NPAtlas curation)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2018-08-06
                          Submitted
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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