BGC0001823: weishanmycin biosynthetic gene cluster from Streptomyces sp. CB02120-2
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Location: 1 - 76,440 nt. (total: 76,440 nt).
This entry is originally from NCBI GenBank MF925482.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001823
Short description weishanmycin biosynthetic gene cluster from Streptomyces sp. CB02120-2
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MF925482.1
via
Compounds
  • weishanmycin
Species Streptomyces sp. CB02120-2 [taxonomy]
References
Chemical products information
weishanmycin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATY69607.1
 4325 - 5209 (+) SAM-dependent methyltransferase
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    • ATY69606.1
    • wsmA
    		 5414 - 6073 (-) Crp/Fnr/Fnr family transcriptional regulator
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      • ATY69605.1
      • wsmB
      		 6228 - 6800 (-) YdeI-like protein
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        • ATY69604.1
        • wsmC
        		 6814 - 7569 (-) phosphopantetheinyl transferase
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          • ATY69603.1
          • wsmD
          		 7809 - 9005 (+) HMG-CoA synthase
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            • ATY69602.1
            • wsmE
            		 8996 - 9802 (+) enoyl-CoA hydratase
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              • ATY69601.1
              • wsmF
              		 9807 - 10679 (+) acyltransferase
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                • ATY69600.1
                • wsmG
                		 10742 - 17185 (+) type I polyketide synthase
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                  • ATY69599.1
                  • wsmH
                  		 17465 - 19030 (+) antibiotic efflux protein
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                    • ATY69598.1
                    • wsmI
                    		 19169 - 19975 (+) hypothetical protein
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                      • ATY69597.1
                      • wsmJ
                      		 19980 - 22301 (+) acyltransferase/oxidoreductase
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                        • ATY69596.1
                        • wsmK
                        		 22406 - 23314 (+) hypothetical protein
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                          • ATY69595.1
                          • wsmL
                          		 23396 - 23761 (-) glyoxalase/bleomycin resistance protein
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                            • ATY69594.1
                            • wsmM
                            		 23928 - 24638 (+) N-acetylglucosaminyl deacetylase
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                              • ATY69593.1
                              • wsmN
                              		 24698 - 25447 (-) methyltransferase
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                                • ATY69592.1
                                • wsmO
                                		 25444 - 26811 (-) putative alpha/beta hydrolase
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                                  • ATY69591.1
                                  • wsmP
                                  		 26906 - 27157 (+) peptidyl carrier protein
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                                    • ATY69590.1
                                    • wsmQ
                                    		 27180 - 28760 (+) adenylation protein
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                                      • ATY69589.1
                                      • wsmR
                                      		 28854 - 51185 (+) type I polyketide synthase
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                                        • ATY69588.1
                                        • wsmS
                                        		 51182 - 52426 (+) HMG-CoA synthase
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                                          • ATY69587.1
                                          • wsmT
                                          		 52449 - 52694 (+) acyl carrier protein
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                                            • ATY69586.1
                                            • wsmU
                                            		 52691 - 53917 (+) beta-ketoacyl-ACP synthase
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                                              • ATY69585.1
                                              • wsmV
                                              		 53883 - 54638 (-) type II thioesterase
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                                                • ATY69584.1
                                                • wsmW
                                                		 54635 - 61369 (-) hybrid nonribosomal peptide synthetase/type I polyketide synthase
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                                                  • ATY69583.1
                                                  • wsmX
                                                  		 61366 - 61791 (-) truncated hemoglobin
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                                                    • ATY69582.1
                                                    • wsmY
                                                    		 61973 - 63199 (+) cytochrome P450 oxygenase
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                                                      • ATY69581.1
                                                      • wsmZ1
                                                      		 63196 - 63420 (+) ferredoxin
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                                                        • ATY69580.1
                                                        • wsmZ2
                                                        		 63479 - 64837 (+) crotonyl-CoA carboxylase/reductase
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                                                          • ATY69579.1
                                                          • wsmZ3
                                                          		 64834 - 65826 (+) ketoacyl-acyl carrier protein synthase III
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                                                            • ATY69578.1
                                                            • wsmZ4
                                                            		 65823 - 66707 (+) 3-hydroxyacyl-CoA dehydrogenase
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                                                              • ATY69577.1
                                                              		 66739 - 68166 (-) peptidase M1
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                                                                Biosynthesis information

                                                                Biosynthetic modules

                                                                Name
                                                                Unk01
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                wsmW
                                                                Substrates
                                                                cysteine (evidence: Structure-based inference)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk02
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                wsmQ
                                                                Substrates
                                                                D-alanine, 1-aminocyclopropane-1-carboxylic acid, glycine, alanine (evidence: Structure-based inference, Feeding study, Homology)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Annotation changelog

                                                                Entry version: 3

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-09-15
                                                                Added NRP substrate specificities
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 2

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2019-10-16
                                                                Migrated from v1.4
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 1

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2018-08-06
                                                                Submitted
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                Detailed domain annotation
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