BGC0001846: valinomycin biosynthetic gene cluster from Streptomyces sp. CBMAI 2042
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Location: 7,605,327 - 7,645,900 nt. (total: 40,574 nt).
This entry is originally from NCBI GenBank RCOL01000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
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NRP
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001846
Short description valinomycin biosynthetic gene cluster from Streptomyces sp. CBMAI 2042
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "This gene cluster is capable to biosynthesize valinomycin, montanastatin and other cyclodepsipeptides derivatives."
Biosynthetic class(es)
  • Saccharide (hybrid/tailoring)
  • NRP
Loci NCBI GenBank: RCOL01000001.1
Compounds
  • valinomycin
  • montanastatin
Species Streptomyces sp. CBMAI 2042 [taxonomy]
References
Chemical products information
valinomycin
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C54H90N6O18
Chemical database entries
PubCHEM
montanastatin [synonyms: octa-valinomycin]
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C36H60N4O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • STAN_6707
  • RLV71178.1
 7605327 - 7606901 (+) Dipeptide ABC transporter, membrane component
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  • STAN_6708
  • RLV71179.1
 7606979 - 7608007 (+) ABC peptide transporter, permease component
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  • STAN_6709
  • RLV71180.1
 7608010 - 7608903 (+) ABC-transport protein, inner membrane component
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  • STAN_6710
  • RLV71181.1
 7608900 - 7609802 (+) ABC transporter ATP-binding protein
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  • STAN_6711
  • RLV71182.1
 7609799 - 7610668 (+) Peptide ABC transporter,ATP-binding protein
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  • STAN_6712
  • RLV71183.1
 7610705 - 7612045 (+) NtaA/SnaA/SoxA family monooxygenase
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  • STAN_6713
  • RLV71184.1
 7612055 - 7613845 (+) 2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase
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  • STAN_6714
  • RLV71185.1
 7613881 - 7614645 (+) Vegetative cell wall protein gp1
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  • STAN_6715
  • RLV71186.1
 7614740 - 7615339 (+) NADPH-dependent FMN reductase
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  • STAN_6716
  • RLV71187.1
 7615453 - 7617072 (+) adenosine deaminase
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  • STAN_6717
  • RLV71188.1
 7617153 - 7617587 (+) SnoaL_3 multi-domain protein
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  • STAN_6718
  • RLV71189.1
 7617584 - 7618756 (+) multidrug transporter
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  • STAN_6719
  • RLV71190.1
 7618798 - 7618866 (+) Alpha-L-rhamnosidase
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  • STAN_6720
  • RLV71191.1
 7618856 - 7619596 (-) GntR family DNA-binding regulator
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  • STAN_6721
  • RLV71192.1
 7619772 - 7627733 (-) non-ribosomal peptide synthetase
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  • STAN_6722
  • RLV71193.1
 7627825 - 7637754 (-) non-ribosomal peptide synthetase
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  • STAN_6723
  • RLV71194.1
 7638143 - 7638649 (-) Discrete type II thioesterase
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  • STAN_6724
  • RLV71195.1
 7638653 - 7639105 (+) hypothetical protein
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  • STAN_6725
  • RLV71196.1
 7639477 - 7641507 (-) iron-hydroxamate transporter permease subunit
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  • STAN_6726
  • RLV71197.1
 7641627 - 7642601 (-) ABC-type transporter, periplasmic subunit
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  • STAN_6727
  • RLV71198.1
 7642610 - 7643407 (-) Iron-chelate-transporting ATPase
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  • STAN_6728
  • RLV71199.1
 7643940 - 7644383 (+) subtilase-type protease inhibitor
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  • STAN_6729
  • RLV71200.1
 7644371 - 7645900 (-) Export protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
STAN_6722
Module 0
Specificity: 2R-hydroxyisovaleric acid
Evidence for specificity:
  • Structure-based inference
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 1
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 2
Condensation domain type: DCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
STAN_6721
Module 2
Specificity: lactic acid
Evidence for specificity:
  • Structure-based inference
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 3
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: LZPDLESQBUEYNBCINTBVVSSE, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Fetch compound properties from PubChem
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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