BGC0001846: valinomycin biosynthetic gene cluster from Streptomyces sp. CBMAI 2042
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Location: 7,605,327 - 7,645,900 nt. (total: 40,574 nt).
This entry is originally from NCBI GenBank RCOL01000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001846
Short description valinomycin biosynthetic gene cluster from Streptomyces sp. CBMAI 2042
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "This gene cluster is capable to biosynthesize valinomycin, montanastatin and other cyclodepsipeptides derivatives."
Biosynthetic class(es)
  • saccharide (hybrid/tailoring)
  • NRPS (Type I)
Loci
RCOL01000001.1
7605327 - 7645900
via Heterologous expression
Compounds
  • valinomycin
  • montanastatin
Species Streptomyces sp. CBMAI 2042 [taxonomy]
References
Chemical products information
valinomycin Evidence: Mass spectrometry
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C54H90N6O18
Chemical database entries
PubCHEM
montanastatin Evidence: Mass spectrometry
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C36H60N4O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • STAN_6707
  • RLV71178.1
 7605327 - 7606901 (+) Dipeptide ABC transporter, membrane component
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    • STAN_6708
    • RLV71179.1
    		 7606979 - 7608007 (+) ABC peptide transporter, permease component
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      • STAN_6709
      • RLV71180.1
      		 7608010 - 7608903 (+) ABC-transport protein, inner membrane component
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        • STAN_6710
        • RLV71181.1
        		 7608900 - 7609802 (+) ABC transporter ATP-binding protein
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          • STAN_6711
          • RLV71182.1
          		 7609799 - 7610668 (+) Peptide ABC transporter,ATP-binding protein
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            • STAN_6712
            • RLV71183.1
            		 7610705 - 7612045 (+) NtaA/SnaA/SoxA family monooxygenase
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              • STAN_6713
              • RLV71184.1
              		 7612055 - 7613845 (+) 2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase
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                • STAN_6714
                • RLV71185.1
                		 7613881 - 7614645 (+) Vegetative cell wall protein gp1
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                  • STAN_6715
                  • RLV71186.1
                  		 7614740 - 7615339 (+) NADPH-dependent FMN reductase
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                    • STAN_6716
                    • RLV71187.1
                    		 7615453 - 7617072 (+) adenosine deaminase
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                      • STAN_6717
                      • RLV71188.1
                      		 7617153 - 7617587 (+) SnoaL_3 multi-domain protein
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                        • STAN_6718
                        • RLV71189.1
                        		 7617584 - 7618756 (+) multidrug transporter
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                          • STAN_6719
                          • RLV71190.1
                          		 7618798 - 7618866 (+) Alpha-L-rhamnosidase
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                            • STAN_6720
                            • RLV71191.1
                            		 7618856 - 7619596 (-) GntR family DNA-binding regulator
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                              • STAN_6721
                              • RLV71192.1
                              		 7619772 - 7627733 (-) non-ribosomal peptide synthetase
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                                • STAN_6722
                                • RLV71193.1
                                		 7627825 - 7637754 (-) non-ribosomal peptide synthetase
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                                  • STAN_6723
                                  • RLV71194.1
                                  		 7638143 - 7638649 (-) Discrete type II thioesterase
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                                    • STAN_6724
                                    • RLV71195.1
                                    		 7638653 - 7639105 (+) hypothetical protein
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                                      • STAN_6725
                                      • RLV71196.1
                                      		 7639477 - 7641507 (-) iron-hydroxamate transporter permease subunit
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                                        • STAN_6726
                                        • RLV71197.1
                                        		 7641627 - 7642601 (-) ABC-type transporter, periplasmic subunit
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                                          • STAN_6727
                                          • RLV71198.1
                                          		 7642610 - 7643407 (-) Iron-chelate-transporting ATPase
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                                            • STAN_6728
                                            • RLV71199.1
                                            		 7643940 - 7644383 (+) subtilase-type protease inhibitor
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                                              • STAN_6729
                                              • RLV71200.1
                                              		 7644371 - 7645900 (-) Export protein
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                                                Biosynthesis information

                                                Biosynthetic modules

                                                Name
                                                0
                                                Type
                                                nrps-type1
                                                Genes
                                                STAN_6722
                                                Substrates
                                                2R-hydroxyisovaleric acid (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                adenylation
                                                Name
                                                1
                                                Type
                                                nrps-type1
                                                Genes
                                                STAN_6722
                                                Substrates
                                                valine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation, epimerase
                                                Name
                                                2
                                                Type
                                                nrps-type1
                                                Genes
                                                STAN_6721
                                                Substrates
                                                lactic acid (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                adenylation
                                                Name
                                                3
                                                Type
                                                nrps-type1
                                                Genes
                                                STAN_6721
                                                Substrates
                                                valine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation
                                                Annotation changelog

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Cleaned up synonym list
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Fetch compound properties from PubChem
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Updated bioactivity data
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Updated NRP substrate specificities
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Submitted
                                                • (ID: LZPDLESQBUEYNBCINTBVVSSE)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Detailed domain annotation
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