BGC0001846 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001846 (Streptomyces sp. CBMAI 2042)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	40,574	valinomycin	NRP:Cyclic depsipeptide	22%

BGC0001846 - Region 1 - NRPS

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Location: 1 - 40,574 nt. (total: 40,574 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 40,575
Label		BGC0001846

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001846.1	1.00	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0000389.1	0.32	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.32	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0002075.1	0.31	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens
BGC0001615.1	0.31	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000351.1	0.28	NRP	exochelin	Mycolicibacterium smegmatis
BGC0000426.1	0.27	NRP	sevadicin	Paenibacillus larvae
BGC0001479.1	0.26	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001825.1	0.26	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000417.1	0.26	NRP	rhodochelin	Rhodococcus jostii RHA1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001846.1	1.00	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0002071.1	0.66	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0002075.1	0.65	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens
BGC0001615.1	0.65	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000351.1	0.62	NRP	exochelin	Mycolicibacterium smegmatis
BGC0000426.1	0.61	NRP	sevadicin	Paenibacillus larvae
BGC0001479.1	0.60	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001825.1	0.60	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000417.1	0.60	NRP	rhodochelin	Rhodococcus jostii RHA1

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 40574:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-val) + (val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

STAN_6721

Search NORINE for peptide: strict or relaxed

CAL_domain (194..628): pk

minowa: AHBA

Prediction, score:

AHBA: 19.3
shikimic_acid: 16.5
NH2: 8.5
fatty_acid: 8.1
Acetyl-CoA: 0.0

AMP-binding (1797..2190): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWvGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

STAN_6722

Search NORINE for peptide: strict or relaxed

CAL_domain (44..349): pk

minowa: NH2

Prediction, score:

NH2: 9.3
Acetyl-CoA: 7.5
shikimic_acid: 0.0
fatty_acid: 0.0
AHBA: 0.0

AMP-binding (1726..2118): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DALWLGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)