BGC0001851: komodoquinone B biosynthetic gene cluster from Streptomyces erythrochromogenes
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Location: 186,424 - 230,323 nt. (total: 43,900 nt).
This entry is originally from NCBI GenBank NZ_JNZG01000006.1.

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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001851
Short description komodoquinone B biosynthetic gene cluster from Streptomyces erythrochromogenes
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II aromatic)
Loci
NZ_JNZG01000006.1
186424 - 230323
via Enzymatic assays
Compounds
  • komodoquinone B
Species Streptomyces erythrochromogenes [taxonomy]
References
Chemical products information
komodoquinone B Evidence: NMR [1]
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C19H16O7
Chemical database entries
ChemSpider
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • IO28_RS0104710
  • WP_245240007.1
 186424 - 187437 (-) 3-ketoreductase
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    • IO28_RS0104715
    • WP_031146979.1
    		 187434 - 188543 (-) aminotransferase
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      • IO28_RS0104720
      • WP_031146981.1
      		 188593 - 189303 (-) aminomethylase
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        • IO28_RS0104725
        • WP_031146983.1
        		 189343 - 190122 (-) 2nd and 3rd ring cyclase
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          • IO28_RS0104730
          • WP_031146985.1
          		 190311 - 190748 (+) unknown
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            • IO28_RS0104735
            • WP_245240009.1
            		 190807 - 191754 (+) 4-ketoreductase
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              • IO28_RS0104740
              • WP_031146990.1
              		 191825 - 192082 (+) acyl carrier protein
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                • IO28_RS0104745
                • WP_031146991.1
                		 192106 - 192825 (-) aminomethylase
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                  • IO28_RS0104750
                  • WP_051892704.1
                  		 193061 - 194257 (+) unknown
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                    • IO28_RS0104755
                    • WP_031146993.1
                    		 194344 - 195561 (+) 3-methyltransferase
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                      • IO28_RS0104760
                      • WP_031146995.1
                      		 195613 - 196986 (+) glycosyltransferase
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                        • IO28_RS0104765
                        • WP_031146996.1
                        		 196983 - 198602 (+) oxidase
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                          • IO28_RS0104770
                          • WP_031146998.1
                          		 198642 - 199760 (-) glycosyltransferase
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                            • IO28_RS0104775
                            • WP_031147000.1
                            		 199921 - 200691 (+) 4,6-dehydratase
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                              • IO28_RS0104780
                              • WP_031147003.1
                              		 200688 - 201893 (+) regulator
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                                • IO28_RS0104785
                                • WP_245240010.1
                                		 201890 - 202996 (+) 10-decarboxylase
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                                  • IO28_RS0104790
                                  • WP_031147007.1
                                  		 203067 - 203960 (+) 15-methylesterase
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                                    • IO28_RS0104795
                                    • WP_031147009.1
                                    		 203974 - 204594 (-) unknown
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                                      • IO28_RS0104800
                                      • WP_031147011.1
                                      		 204622 - 205056 (-) 4th ring cyclase
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                                        • IO28_RS0104805
                                        • WP_031147013.1
                                        		 205305 - 205655 (+) monooxygenase
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                                          • IO28_RS0104810
                                          • WP_031147015.1
                                          		 205655 - 206935 (+) ketosynthase α-subunit
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                                            • IO28_RS0104815
                                            • WP_031147017.1
                                            		 206932 - 208152 (+) ketosynthase β-subunit
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                                              • IO28_RS0104820
                                              • WP_031147019.1
                                              		 208161 - 208946 (+) 9-ketoreductase
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                                                • IO28_RS0104825
                                                • WP_031147021.1
                                                		 208977 - 209930 (+) aromatase
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                                                  • IO28_RS0104830
                                                  • WP_031147023.1
                                                  		 209930 - 211246 (+) glycosyltransferase
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                                                    • IO28_RS0104835
                                                    • WP_051892705.1
                                                    		 211239 - 212030 (+) 7-ketoreductase
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                                                      • IO28_RS0104840
                                                      • WP_031147027.1
                                                      		 212095 - 213381 (+) P450-like
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                                                        • IO28_RS0104845
                                                        • WP_245240025.1
                                                        		 213583 - 214467 (+) ABC transporter
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                                                          • IO28_RS0104850
                                                          • WP_030957368.1
                                                          		 214464 - 215318 (+) ABC transporter
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                                                            • IO28_RS40515
                                                            • WP_037631637.1
                                                            		 215488 - 215712 (+) regulator
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                                                              • IO28_RS0104860
                                                              • WP_031147034.1
                                                              		 215777 - 217063 (-) glycosyltransferase
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                                                                • IO28_RS0104865
                                                                • WP_031147036.1
                                                                		 217231 - 218838 (+) 11-hydroxylase
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                                                                  • IO28_RS0104870
                                                                  • WP_031147038.1
                                                                  		 218887 - 219681 (+) 2-oxoglutarate and non-heme iron family
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                                                                    • IO28_RS0104875
                                                                    • WP_051892707.1
                                                                    		 219706 - 220869 (+) cytochrome P450-like
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                                                                      • IO28_RS0104880
                                                                      • WP_031147042.1
                                                                      		 220897 - 222180 (+) glycosyltransferase
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                                                                        • IO28_RS0104885
                                                                        • WP_031147044.1
                                                                        		 222258 - 223067 (+) unknown
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                                                                          • IO28_RS0104890
                                                                          • WP_051892708.1
                                                                          		 223089 - 224333 (+) unknown
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                                                                            • IO28_RS0104895
                                                                            • WP_031147048.1
                                                                            		 224311 - 225171 (-) 15- methyltransferase
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                                                                              • IO28_RS0104900
                                                                              • WP_158714712.1
                                                                              		 225466 - 226074 (+) 3,5-epimerase
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                                                                                • IO28_RS0104905
                                                                                • WP_209441455.1
                                                                                		 226159 - 227631 (-) 2,3-dehydratase
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                                                                                  • IO28_RS0104910
                                                                                  • WP_266496847.1
                                                                                  		 228395 - 230323 (+) SARP family regulator
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                                                                                    Biosynthesis information
                                                                                    Annotation changelog

                                                                                    Entry version: next

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2024-04-23
                                                                                    MIBiG v4 annotathon
                                                                                    • (ID: K5UBFDWZSYOHS4HI42NVQMJK)
                                                                                    • (ID: N36AXMAR75OH4EWIMJIU5WOH)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 3

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-10-07
                                                                                    Update chemical activity to schema version 2.11
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 2

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-09-15
                                                                                    Fix missing gene identifiers
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2022-09-15
                                                                                    Removed gene names of 'No gene ID'
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2022-09-15
                                                                                    Removed gene annotations with no information
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2022-09-15
                                                                                    Updated bioactivity data
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 1

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2019-10-16
                                                                                    Submitted
                                                                                    • (ID: K5UBFDWZSYOHS4HI42NVQMJK)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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