BGC0001856: caniferolide A biosynthetic gene cluster from Streptomyces caniferus
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Location: 1 - 186,923 nt. (total: 186,923 nt).
This entry is originally from NCBI GenBank MK303577.1.

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001856
Short description caniferolide A biosynthetic gene cluster from Streptomyces caniferus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
MK303577.1
via
Compounds
  • caniferolide A
  • caniferolide B
  • caniferolide C
  • caniferolide D
Species Streptomyces caniferus [taxonomy]
References
Chemical products information
caniferolide A Evidence: NMR
(no structure information available)
C77H122O31S1
caniferolide B Evidence: NMR
(no structure information available)
C77H122O28
caniferolide C Evidence: NMR
(no structure information available)
C77H122O27
caniferolide D Evidence: NMR
(no structure information available)
C77H122O30S1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QBF51744.1
  • scaH1
 1 - 717 (-) hypothetical protein
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    • QBF51745.1
    • scaH2
    		 1051 - 1758 (+) hypothetical protein
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      • QBF51746.1
      • scaH3
      		 1891 - 2115 (-) hypothetical protein
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        • QBF51747.1
        • scaPT
        		 2441 - 3160 (+) 4'-phosphopantetheinyl transferase
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          • QBF51748.1
          • scaTR1
          		 3265 - 6141 (-) LuxR family transcriptional regulator
          • Regulation
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          • QBF51749.1
          • scaTR2
          		 7173 - 8018 (-) PAS-LuxR transcriptional regulator
          • Regulation
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          • QBF51750.1
          • scaTR3
          		 8365 - 11175 (-) LuxR family transcriptional regulator
          • Regulation
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          • QBF51751.1
          • scaTR4
          		 12219 - 12995 (+) GntR family transcriptional regulator
          • Regulation
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          • QBF51752.1
          • scaTR5
          		 13079 - 13711 (+) TetR family transcriptional regulator
          • Regulation
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          • QBF51753.1
          • scaDH1
          		 13842 - 15254 (-) NDP-hexose 2,3-dehydratase
          • Precursor biosynthesis
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          • QBF51754.1
          • scaP1
          		 15620 - 28261 (+) type I polyketide synthase
          • Scaffold biosynthesis
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          • QBF51755.1
          • scaP2
          		 28308 - 43157 (+) type I polyketide synthase
          • Scaffold biosynthesis
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          • QBF51756.1
          • scaP3
          		 43483 - 55263 (+) type I polyketide synthase
          • Scaffold biosynthesis
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          • QBF51757.1
          • scaP4
          		 55319 - 71188 (+) type I polyketide synthase
          • Scaffold biosynthesis
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          • QBF51758.1
          • scaP5
          		 71238 - 96572 (+) type I polyketide synthase
          • Scaffold biosynthesis
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          • QBF51759.1
          • scaP6
          		 96615 - 112340 (+) type I polyketide synthase
          • Scaffold biosynthesis
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          • QBF51760.1
          • scaP7
          		 112387 - 123315 (+) type I polyketide synthase
          • Scaffold biosynthesis
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          • QBF51761.1
          • scaF1
          		 123499 - 123702 (+) ferredoxin
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            • QBF51762.1
            • scaCP1
            		 123732 - 124946 (-) cytochrome P450
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              • QBF51763.1
              • scaGT1
              		 125364 - 126620 (+) glycosyltransferase
              • Tailoring
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              • QBF51764.1
              • scaGS
              		 126678 - 127754 (+) glucose-1-phosphate thymidyltransferase
              • Precursor biosynthesis
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              • QBF51765.1
              • scaDH2
              		 127856 - 128857 (+) NDP-glucose-4,6-dehydratase
              • Precursor biosynthesis
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              • QBF51766.1
              • scaR1
              		 128893 - 129864 (+) NAD(P)H-dependent ketoreductase
              • Precursor biosynthesis
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              • QBF51767.1
              • scaGT2
              		 129967 - 131193 (+) glycosyltransferase
              • Tailoring
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              • QBF51768.1
              • scaDH3
              		 131283 - 132584 (-) PMP-dependent NDP-4-keto-hexose 3-dehydratase
              • Precursor biosynthesis
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              • QBF51769.1
              • scaP8
              		 133114 - 140286 (+) type I polyketide synthase
              • Scaffold biosynthesis
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              • QBF51770.1
              • scaS
              		 140321 - 141352 (+) 3-oxoacyl-ACP synthase
              • Scaffold biosynthesis
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              • QBF51771.1
              • scaA
              		 141448 - 141885 (+) cold-shock domain-containing protein
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                • QBF51772.1
                • scaT1
                		 142323 - 143174 (-) ABC transporter permease component
                • Transport
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                • QBF51773.1
                • scaT2
                		 143201 - 143983 (-) ABC transporter permease component
                • Transport
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                • QBF51774.1
                • scaR2
                		 144167 - 145147 (-) NAD(P)H-dependent ketoreductase
                • Precursor biosynthesis
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                • QBF51775.1
                • scaE
                		 145140 - 145760 (-) dTDP-4-keto-2,6-dideoxy-3,5-epimerase
                • Precursor biosynthesis
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                • QBF51776.1
                • scaCM
                		 146066 - 147298 (-) NDP-hexose-3-C-methyltransferase
                • Precursor biosynthesis
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                • QBF51777.1
                • scaH4
                		 147727 - 148458 (+) hypothetical protein
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                  • QBF51778.1
                  • scaST
                  		 148720 - 150009 (+) sulfotransferase
                  • Tailoring
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                  • QBF51779.1
                  • scaSK
                  		 150011 - 150616 (+) adenylyl-sulfate kinase
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                    • QBF51780.1
                    • scaO1
                    		 150674 - 150844 (+) truncated flavin-dependent oxidoreductase
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                      • QBF51781.1
                      • scaO2
                      		 150895 - 151689 (+) flavin-dependent oxidoreductase
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                        • QBF51782.1
                        • scaB
                        		 152120 - 152332 (-) truncated IS481 family transposase
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                          • QBF51783.1
                          • scaC
                          		 152379 - 153557 (-) efflux permease, MFS family
                          • Transport
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                          • QBF51784.1
                          • scaD
                          		 153825 - 154376 (-) acetyltransferase
                          • Tailoring
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                          • QBF51785.1
                          • scaF
                          		 154446 - 155492 (+) LD-carboxypeptidase
                          • Tailoring
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                          • QBF51786.1
                          • scaG
                          		 155569 - 158616 (-) Nrps
                          • Scaffold biosynthesis
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                          • QBF51787.1
                          • scaI
                          		 158814 - 168908 (-) IPT/TIG domain-containing protein
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                            • QBF51788.1
                            • scaH5
                            		 169321 - 170304 (-) hypothetical protein
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                              • QBF51789.1
                              • scaH6
                              		 170301 - 170702 (-) hypothetical protein
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                                • QBF51790.1
                                • scaT
                                		 171023 - 171793 (+) thioesterase
                                • Scaffold biosynthesis
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                                • QBF51791.1
                                • scaM1
                                		 171841 - 172746 (+) menaquinone biosynthesis
                                • Precursor biosynthesis
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                                • QBF51792.1
                                • scaM2
                                		 172748 - 174016 (+) menaquinone biosynthesis
                                • Precursor biosynthesis
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                                • QBF51793.1
                                • scaF2
                                		 174253 - 174558 (-) ferredoxin
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                                  • QBF51794.1
                                  • scaM3
                                  		 174619 - 175788 (-) menaquinone biosynthesis
                                  • Precursor biosynthesis
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                                  • QBF51795.1
                                  • scaJ
                                  		 175848 - 176930 (-) putative arylcarboxylate reductase
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                                    • QBF51796.1
                                    • scaM4
                                    		 177175 - 178038 (+) menaquinone biosynthesis
                                    • Precursor biosynthesis
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                                    • QBF51797.1
                                    • scaTR6
                                    		 178099 - 178674 (-) TetR family transcriptional regulator
                                    • Transport
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                                    • QBF51798.1
                                    • scaH7
                                    		 178769 - 179215 (+) hypothetical protein
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                                      • QBF51799.1
                                      • scaR3
                                      		 179338 - 180417 (-) NDP-hexose-3-ketoreductase
                                      • Precursor biosynthesis
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                                      • QBF51800.1
                                      • scaCP2
                                      		 180530 - 181747 (-) cytochrome P450
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                                        • QBF51801.1
                                        • scaK
                                        		 182281 - 183870 (-) carboxyl-transferase
                                        • Tailoring
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                                        • QBF51802.1
                                        • scaL
                                        		 183926 - 185251 (-) ATP-dependent acyl-CoA synthetase
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                                          • QBF51803.1
                                          • scaN
                                          		 185641 - 186549 (+) putative carboxylesterase
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                                            • QBF51804.1
                                            • scaH8
                                            		 186504 - 186689 (-) hypothetical protein
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                                              • QBF51805.1
                                              • scaH9
                                              		 186707 - 186922 (-) hypothetical protein
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                                                Biosynthesis information

                                                Biosynthetic modules

                                                Name
                                                1
                                                Type
                                                pks-modular
                                                Genes
                                                scaP1
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                Name
                                                2
                                                Type
                                                pks-modular
                                                Genes
                                                scaP1
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                3
                                                Type
                                                pks-modular
                                                Genes
                                                scaP1
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                4
                                                Type
                                                pks-modular
                                                Genes
                                                scaP2
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                5
                                                Type
                                                pks-modular
                                                Genes
                                                scaP2
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                6
                                                Type
                                                pks-modular
                                                Genes
                                                scaP2
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                Name
                                                7
                                                Type
                                                pks-modular
                                                Genes
                                                scaP3
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                Name
                                                8
                                                Type
                                                pks-modular
                                                Genes
                                                scaP3
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                Name
                                                9
                                                Type
                                                pks-modular
                                                Genes
                                                scaP4
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                Name
                                                10
                                                Type
                                                pks-modular
                                                Genes
                                                scaP4
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                11
                                                Type
                                                pks-modular
                                                Genes
                                                scaP4
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                12
                                                Type
                                                pks-modular
                                                Genes
                                                scaP5
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                13
                                                Type
                                                pks-modular
                                                Genes
                                                scaP5
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                14
                                                Type
                                                pks-modular
                                                Genes
                                                scaP5
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
                                                Name
                                                15
                                                Type
                                                pks-modular
                                                Genes
                                                scaP5
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                16
                                                Type
                                                pks-modular
                                                Genes
                                                scaP5
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                Name
                                                17
                                                Type
                                                pks-modular
                                                Genes
                                                scaP6
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                18
                                                Type
                                                pks-modular
                                                Genes
                                                scaP6
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                Name
                                                19
                                                Type
                                                pks-modular
                                                Genes
                                                scaP6
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                20
                                                Type
                                                pks-modular
                                                Genes
                                                scaP7
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                21
                                                Type
                                                pks-modular
                                                Genes
                                                scaP7
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, thioesterase, carrier (ACP)
                                                Name
                                                22
                                                Type
                                                pks-trans-at-starter
                                                Genes
                                                scaP8
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                ligase, carrier (ACP)
                                                Name
                                                23
                                                Type
                                                pks-modular
                                                Genes
                                                scaP8
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                Annotation changelog

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Corrected PKS module numbers
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Updated bioactivity data
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Submitted
                                                • (ID: AKJHE6WY6NZKFMVL6KWSMX5H)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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