BGC0001873: pyrrolizixenamide A biosynthetic gene cluster from Xenorhabdus szentirmaii DSM 16338
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Location: 1,647,608 - 1,656,213 nt. (total: 8,606 nt).
This entry is originally from NCBI GenBank NZ_NIBV01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001873
Short description pyrrolizixenamide A biosynthetic gene cluster from Xenorhabdus szentirmaii DSM 16338
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_NIBV01000002.1
1647608 - 1656213
via Heterologous expression
Compounds
  • pyrrolizixenamide A
Species Xenorhabdus szentirmaii DSM 16338 [taxonomy]
References
Chemical products information
pyrrolizixenamide A Evidence: Mass spectrometry
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C13H20N2O2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Xsze_RS17110
  • WP_038234862.1
 1647608 - 1648786 (-) FAD-dependent monooxygenase
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    • Xsze_RS17115
    • WP_051462298.1
    		 1648771 - 1656213 (-) non-ribosomal peptide synthetase
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      Biosynthesis information

      Biosynthetic modules

      Name
      1
      Type
      nrps-type1
      Genes
      Xsze_RS17115
      Substrates
      serine (evidence: Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation (Starter), adenylation
      Name
      2
      Type
      nrps-type1
      Genes
      Xsze_RS17115
      Substrates
      proline (evidence: Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation (DCL), adenylation
      Annotation changelog

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Corrected NRP module activity
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Changed amino acid substrates to lower case
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Submitted
      • (ID: EAEHVVGBLF6RHLSTHI74QVQ6)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Detailed domain annotation
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