BGC0001886 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001886 (Claviceps purpurea 20.1)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	56,704	High	Secalonic acid B/Secalonic acid A/Secalonic acid C/Endocrocin/Clavorubin	PKS

BGC0001886 - Region 1 - T1PKS

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Location: 1 - 56,704 nt. (total: 56,704 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 56,705
Label		BGC0001886

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CPUR_05429: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 80.80%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CPUR_05431: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: acylase methyltransferase

CPUR_05424: methyltransferase

smcogs: SMCOG1089: methyltransferase

CPUR_05432: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

CPUR_05437: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

CPUR_05436: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 62.60%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: Dehydration hydrolase

CPUR_05428: Dehydration

MITE: MITE0000159Dehydration (identity: 64.50%)

CPUR_05436: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 62.60%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: dehydrogenase

CPUR_05429: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 80.80%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001886.2	0.98	PKS	Secalonic acid B, Secalonic acid A, Secalonic acid C, Endocrocin, Clavorubin	Claviceps purpurea 20.1
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.75	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000156.5	0.63	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001886.2	1.00	PKS	Secalonic acid B, Secalonic acid A, Secalonic acid C, Endocrocin, Clavorubin	Claviceps purpurea 20.1
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.75	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000156.5	0.63	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 10967 - 56704:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CPUR_05437: mal

PKS_AT (942..1245): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 94.1
inactive: 65.6
Methoxymalonyl-CoA: 47.3
Methylmalonyl-CoA: 46.6
Propionyl-CoA: 29.4
Isobutyryl-CoA: 24.2
Benzoyl-CoA: 16.9
2-Methylbutyryl-CoA: 16.3
CHC-CoA: 13.4
Ethylmalonyl-CoA: 12.6
Acetyl-CoA: 7.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor