BGC0001910: cyslabdan A biosynthetic gene cluster from Streptomyces cyslabdanicus
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Location: 1 - 12,425 nt. (total: 12,425 nt).
This entry is originally from NCBI GenBank LC064028.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
Operons
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001910
Short description cyslabdan A biosynthetic gene cluster from Streptomyces cyslabdanicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Diterpene)
Loci
LC064028.1
via
Compounds
  • cyslabdan A
  • cyslabdan B
  • cyslabdan C
Species Streptomyces cyslabdanicus [taxonomy]
References
Chemical products information
cyslabdan A Evidence: Mass spectrometry [1]
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C25H41N1O5S1
Chemical database entries
PubCHEM
cyslabdan B Evidence: Mass spectrometry [1]
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C25H41N1O6S1
Chemical database entries
NPAtlas
cyslabdan C Evidence: Mass spectrometry [1]
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C25H41N1O6S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAR97444.1
 238 - 732 (+) acetyltransferase
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    • BAR97445.1
    • cvnA
    		 1305 - 2657 (+) histidine sensor kinase
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      • BAR97446.1
      • cvnB
      		 2654 - 3088 (+) hypothetical protein
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        • BAR97447.1
        • cvnC
        		 3085 - 3456 (+) hypothetical protein
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          • BAR97448.1
          • cvnD
          		 3437 - 4033 (+) ATP/GTP-binding protein
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            • BAR97449.1
            		 4030 - 5268 (+) cytochrome P450
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              • BAR97450.1
              • cldA
              		 5403 - 6488 (+) geranylgeranyl diphosphate synthase
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                • BAR97451.1
                • cldB
                		 6485 - 8083 (+) labdadienyl diphosphate synthase
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                  • BAR97452.1
                  • cldC
                  		 8132 - 9496 (+) Cytochrome P450
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                    • BAR97453.1
                    • cldD
                    		 9493 - 10482 (+) labdatriene synthase
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                      • BAR97454.1
                      		 10784 - 11923 (-) amidase
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                        Biosynthesis information

                        Biosynthetic paths

                        8,17-epoxy-7-hydroxylabda-12,14-diene
                        Show structure
                        Pathway: cldA > cldB > cldD > cldC [1]
                        Subcluster
                        Operons
                        Genes Evidence
                        cldA, cldC, cldB, cldD
                        Annotation changelog

                        Entry version: next

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2024-05-14
                        MIBiG v4 annotathon
                        • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                        • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                        • (ID: CVBS4CX3MGQ2Y6Q45INSO263)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Cleaned up synonym list
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Fetch compound properties from PubChem
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Updated bioactivity data
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Submitted
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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