BGC0001922 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001922 (Streptomyces sp. SoC090715LN-16)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	37,780	High	isoindolinomycin	PKS

BGC0001922 - Region 1 - T2PKS

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Location: 1 - 37,780 nt. (total: 37,780 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,781
Label		BGC0001922

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase

idmB10: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

idmB28: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

idmB32: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

idmB37: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

idmB38: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

idmB5: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

idmB7: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: aminotransferase carboxylase glycosyltransferase halogenase methyltransferase transferase

idmB13: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

idmB15: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

idmB24: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

idmB26: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

idmB3: aminotransferase

smcogs: SMCOG1019: aminotransferase

idmB30: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

idmB39: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

idmB4: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

idmB9: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: esterase

idmB12: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase dehydratase

idmB20: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

idmB22: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

idmB29: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

idmB17: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

idmB18: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

idmB21: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001922.4	0.99	PKS	isoindolinomycin	Streptomyces sp. SoC090715LN-16
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.76	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000237.5	0.67	PKS	lactonamycin Z	Streptomyces sanglieri
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001922.4	0.99	PKS	isoindolinomycin	Streptomyces sp. SoC090715LN-16
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.76	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000237.5	0.67	PKS	lactonamycin Z	Streptomyces sanglieri
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

idmB21: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (12..415): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFFLCLLSK
Nearest Stachelhaus code(s):: Gly DLFFLCLLSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 37780
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)

idmB17: CLF (Score: 630.4; E-value: 2.7e-192)
idmB18: KS (Score: 707.1; E-value: 1.5e-215)
idmB19: CYC C5-C18 (Score: 171.8; E-value: 1.4e-53)
idmB20: CYC C4-C21/C2-C23|C2-C19 (Score: 135.1; E-value: 1.9e-42)
idmB22: CYC C9-C14 (Score: 234.0; E-value: 1.3e-72)
idmB24: MET C11O (Score: 505.8; E-value: 1.1e-154)
idmB25: ACP (Score: 99.8; E-value: 1.5e-31)
idmB26: HAL (Score: 392.8; E-value: 4.5e-120)
idmB28: KR (Score: 46.9; E-value: 6.4e-15)
idmB30: GT (Score: 399.3; E-value: 5.6e-122)
idmB32: OXY (Score: 228.7; E-value: 3.3e-70)
idmB39: MET (Score: 214.2; E-value: 6.3e-66)
idmB4: MET C13O|C17O (Score: 451.1; E-value: 4.6e-138)
idmB5: KR (Score: 129.4; E-value: 4.4e-40)