BGC0001942: malonomycin biosynthetic gene cluster from Streptomyces rimosus subsp. paromomycinus
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Location: 1 - 35,061 nt. (total: 35,061 nt).
This entry is originally from NCBI GenBank MH104947.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001942
Short description malonomycin biosynthetic gene cluster from Streptomyces rimosus subsp. paromomycinus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MH104947.1
via
Compounds
  • malonomycin
Species Streptomyces rimosus subsp. paromomycinus [taxonomy]
References
Chemical products information
malonomycin Evidence:
Copy SMILES
C13H18N4O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AYJ71711.1
  • lipMt
 1091 - 2104 (+) SAM-dependent O-methyltransferase
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    • AYJ71712.1
    • mloA
    		 2483 - 4243 (+) non-ribosomal peptide synthetase
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      • AYJ71713.1
      • mloB
      		 4366 - 7530 (+) non-ribosomal peptide synthetase
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        • AYJ71714.1
        • mloC
        		 7542 - 8345 (+) thioesterase
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          • AYJ71715.1
          • mloD
          		 8458 - 10197 (+) multidrug ABC transporter ATP-binding protein
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            • AYJ71716.1
            • mloE
            		 10194 - 11903 (+) multidrug ABC transporter
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              • AYJ71717.1
              • mloF
              		 11900 - 12928 (+) cysteine synthase
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                • AYJ71718.1
                • mloG
                		 12969 - 13970 (+) ornithine cyclodeaminase
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                  • AYJ71719.1
                  • mloH
                  		 14038 - 15537 (+) vitamin K-dependent carboxylase
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                    • AYJ71720.1
                    • mloI
                    		 15600 - 22022 (+) non-ribosomal peptide synthetase
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                      • AYJ71721.1
                      • mloJ
                      		 22012 - 29118 (+) non-ribosomal peptide synthetase
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                        • AYJ71722.1
                        • mloK
                        		 29115 - 29873 (+) acetyltransferase
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                          • AYJ71723.1
                          • mloL
                          		 29911 - 31398 (+) phytoene dehydrogenase-like oxidoreductase
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                            • AYJ71724.1
                            • mloM
                            		 31403 - 32431 (-) LuxR family transcriptional regulator
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                              • AYJ71725.1
                              • mloN
                              		 32898 - 33836 (+) oxidoreductase
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                                • AYJ71726.1
                                		 34059 - 34490 (-) hypothetical protein
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                                  • AYJ71727.1
                                  		 34535 - 34702 (-) two component LuxR family transcriptional regulator
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                                    • AYJ71728.1
                                    		 34720 - 34935 (-) two component transcriptional regulator, LuxR family
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      Unk01
                                      Type
                                      nrps-type1
                                      Genes
                                      mloI
                                      Substrates
                                      serine (evidence: Structure-based inference, Knock-out studies, ACVS assay)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk02
                                      Type
                                      nrps-type1
                                      Genes
                                      mloI
                                      Substrates
                                      aspartic acid branched, asparagine (evidence: Structure-based inference, Knock-out studies, ACVS assay)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk03
                                      Type
                                      nrps-type1
                                      Genes
                                      mloJ
                                      Substrates
                                      2,3-diaminopropionic acid (evidence: Structure-based inference, Knock-out studies)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Annotation changelog

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Cleaned up synonym list
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Fetch compound properties from PubChem
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Fixed DOIs
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Submitted
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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