BGC0001942: malonomycin biosynthetic gene cluster from Streptomyces rimosus subsp. paromomycinus
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Location: 1 - 35,061 nt. (total: 35,061 nt).
This entry is originally from NCBI GenBank MH104947.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001942
Short description malonomycin biosynthetic gene cluster from Streptomyces rimosus subsp. paromomycinus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: MH104947.1
Compounds
  • malonomycin
Species Streptomyces rimosus subsp. paromomycinus [taxonomy]
References
Chemical products information
malonomycin [synonyms: Malonomicin]
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C13H18N4O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AYJ71711.1
  • lipMt
 1091 - 2104 (+) SAM-dependent O-methyltransferase
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  • AYJ71712.1
  • mloA
 2483 - 4243 (+) non-ribosomal peptide synthetase
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  • AYJ71713.1
  • mloB
 4366 - 7530 (+) non-ribosomal peptide synthetase
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  • AYJ71714.1
  • mloC
 7542 - 8345 (+) thioesterase
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  • AYJ71715.1
  • mloD
 8458 - 10197 (+) multidrug ABC transporter ATP-binding protein
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  • AYJ71716.1
  • mloE
 10194 - 11903 (+) multidrug ABC transporter
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  • AYJ71717.1
  • mloF
 11900 - 12928 (+) cysteine synthase
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  • AYJ71718.1
  • mloG
 12969 - 13970 (+) ornithine cyclodeaminase
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  • AYJ71719.1
  • mloH
 14038 - 15537 (+) vitamin K-dependent carboxylase
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  • AYJ71720.1
  • mloI
 15600 - 22022 (+) non-ribosomal peptide synthetase
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  • AYJ71721.1
  • mloJ
 22012 - 29118 (+) non-ribosomal peptide synthetase
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  • AYJ71722.1
  • mloK
 29115 - 29873 (+) acetyltransferase
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  • AYJ71723.1
  • mloL
 29911 - 31398 (+) phytoene dehydrogenase-like oxidoreductase
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  • AYJ71724.1
  • mloM
 31403 - 32431 (-) LuxR family transcriptional regulator
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  • AYJ71725.1
  • mloN
 32898 - 33836 (+) oxidoreductase
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  • AYJ71726.1
 34059 - 34490 (-) hypothetical protein
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  • AYJ71727.1
 34535 - 34702 (-) two component LuxR family transcriptional regulator
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  • AYJ71728.1
 34720 - 34935 (-) two component transcriptional regulator, LuxR family
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
mloI
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
  • ACVS assay
Module ?
Specificity: aspartic acid branched / asparagine
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
  • ACVS assay
mloJ
Module ?
Specificity: 2,3-diaminopropionic acid
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Hidden contributor (ID: CUSGWVK3I4TVHJH7NHPFAP2L, no GDPR consent given).
  • Cleaned up synonym list
  • Fetch compound properties from PubChem
  • Fixed DOIs
  • Added NRP substrate specificities
Detailed domain annotation
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