BGC0001942 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001942 (Streptomyces paromomycinus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,NRPS-like	1	35,061	s56-p1	NRP	5%

BGC0001942 - Region 1 - NRPS,NRPS-like

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Location: 1 - 35,061 nt. (total: 35,061 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 35,062
Label		BGC0001942

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001942.1	1.69	NRP, Polyketide	malonomycin	Streptomyces rimosus subsp. paromomycinus
BGC0000375.1	0.69	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000465.1	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000900.1	0.64	Other	ferrichrome	Aspergillus oryzae
BGC0001261.1	0.63	NRP	AM-toxin	Alternaria alternata
BGC0000348.1	0.63	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001249.1	0.63	NRP	dimethylcoprogen	Alternaria alternata
BGC0001132.1	0.62	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001527.1	0.62	Other	basidioferrin	Gelatoporia subvermispora

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001942.1	1.00	NRP, Polyketide	malonomycin	Streptomyces rimosus subsp. paromomycinus
BGC0000375.1	0.68	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000465.1	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.66	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000900.1	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0001135.1	0.65	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.1	0.65	NRP	AM-toxin	Alternaria alternata
BGC0000389.1	0.65	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000457.1	0.65	NRP	vicibactin	Rhizobium etli CFN 42

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 35061:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu) + (val) + (ser - X) + (mal - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 1090 - 22022:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu) + (val) + (ser - X) + (mal - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

mloA

Search NORINE for peptide: strict or relaxed

AMP-binding (13..409): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: phe, trp
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAFvgGCTgK
Nearest Stachelhaus code:: val, ile
Stachelhaus code match:: 70% (weak)

mloB

Search NORINE for peptide: strict or relaxed

AMP-binding (26..419): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DgLWLGGiFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 80% (moderate)

mloI

Search NORINE for peptide: strict or relaxed

AMP-binding (475..871): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSyVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 90% (moderate)

AMP-binding (1532..1942): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVrHFaLmaK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 60% (weak)

mloJ

Search NORINE for peptide: strict or relaxed

AMP-binding (1322..1730): X

NRPSPredictor2: hydrophobic-aromatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiWeMtadDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 50% (weak)