BGC0001960 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001960 (Streptomyces hiroshimensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	34,352	High	hiroshidine	PKS

BGC0001960 - Region 1 - T2PKS

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Location: 1 - 34,352 nt. (total: 34,352 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,353
Label		BGC0001960

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

hrsA3: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

hrsG: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

hrsK1: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

hrsK3: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

hrsK4: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

hrsK5: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

hrsO: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

hrsP1: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

hrsP2: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: PPTase aminotransferase glycosyltransferase methyltransferase transferase

hrsA4: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

hrsB: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

hrsC: methyltransferase

smcogs: SMCOG1089: methyltransferase

hrsD: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

hrsE: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

hrsJ: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase

hrsI: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: cyclase dehydratase

hrsA1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

hrsI2: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

hrsM1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

hrsM2: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001960.2	1.00	PKS	hiroshidine	Streptomyces hiroshimensis
BGC0000231.5	0.70	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000278.3	0.63	PKS	urdamycin	Streptomyces fradiae
BGC0001723.5	0.62	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000275.4	0.57	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.57	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000271.5	0.55	PKS	spore pigment	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001960.2	1.00	PKS	hiroshidine	Streptomyces hiroshimensis
BGC0000231.5	0.70	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000278.3	0.63	PKS	urdamycin	Streptomyces fradiae
BGC0001723.5	0.62	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000275.4	0.57	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.57	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000271.5	0.55	PKS	spore pigment	Streptomyces avermitilis

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 34352
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 7 (Score: 724.0; E-value: 9.4e-221)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: acetyl-CoA_7: 506 Da

hrsC: MET (Score: 40.7; E-value: 3.7e-13)
hrsD: GT (Score: 375.4; E-value: 9.9e-115)
hrsI: CYC C5-C14 (Score: 505.4; E-value: 1.1e-154)
hrsI2: CYC C7-C12 (Score: 447.7; E-value: 3.8e-137)
hrsK3: KR C9 (Score: 438.1; E-value: 2.3e-134)
hrsK4: KR (Score: 129.6; E-value: 3.9e-40)
hrsK5: KR (Score: 95.2; E-value: 1.2e-29)
hrsL: ACP (Score: 116.7; E-value: 8.3e-37)
hrsM1: KS (Score: 780.0; E-value: 1.2e-237)
hrsM2: CLF 7 (Score: 724.0; E-value: 9.4e-221)