BGC0001965: nybomycin biosynthetic gene cluster from Streptomyces albus subsp. chlorinus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 30,490 nt. (total: 30,490 nt).
This entry is originally from NCBI GenBank MH924838.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001965
Short description nybomycin biosynthetic gene cluster from Streptomyces albus subsp. chlorinus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
MH924838.1
via
Compounds
  • nybomycin
Species Streptomyces albus subsp. chlorinus [taxonomy]
References
Chemical products information
nybomycin Evidence:
Copy SMILES
C16H14N2O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AYV61398.1
  • orf-04
 1 - 510 (-) hypothetical protein
    copy AA seq
    copy Nt seq
    • AYV61399.1
    • orf-03
    		 659 - 1006 (+) hypothetical protein
      copy AA seq
      copy Nt seq
      • AYV61400.1
      • orf-02
      		 1160 - 2428 (-) hypothetical protein
        copy AA seq
        copy Nt seq
        • AYV61401.1
        • orf-01
        		 2432 - 3322 (+) hypothetical protein
          copy AA seq
          copy Nt seq
          • AYV61402.1
          • nybA
          		 3807 - 5234 (-) 3-carboxy-ciscis-muconate cycloisomerase
            copy AA seq
            copy Nt seq
            • AYV61403.1
            • nybB
            		 5231 - 7240 (-) FAD-binding protein
              copy AA seq
              copy Nt seq
              • AYV61404.1
              • nybC
              		 7493 - 8470 (+) NADPH:quinone reductase
                copy AA seq
                copy Nt seq
                • AYV61405.1
                • nybD
                		 8545 - 10461 (-) anthranilate synthase
                  copy AA seq
                  copy Nt seq
                  • AYV61406.1
                  • nybE
                  		 10458 - 11141 (-) isochorismatase
                    copy AA seq
                    copy Nt seq
                    • AYV61407.1
                    • nybF
                    		 11337 - 12545 (-) DAHP synthase
                      copy AA seq
                      copy Nt seq
                      • AYV61408.1
                      • nybG
                      		 12557 - 13396 (+) hypothetical protein
                        copy AA seq
                        copy Nt seq
                        • AYV61409.1
                        • nybH
                        		 13220 - 13993 (-) vicinal oxygen chelate protein
                          copy AA seq
                          copy Nt seq
                          • AYV61410.1
                          • nybI
                          		 14004 - 14672 (-) NAD\(P\)H:dehydrogenase
                            copy AA seq
                            copy Nt seq
                            • AYV61411.1
                            • nybJ
                            		 14872 - 15279 (+) hypothetical protein
                              copy AA seq
                              copy Nt seq
                              • AYV61412.1
                              • nybK
                              		 15461 - 16261 (-) N-acetyltransferase
                                copy AA seq
                                copy Nt seq
                                • AYV61413.1
                                • nybL
                                		 16263 - 17264 (-) amidohydrolase
                                  copy AA seq
                                  copy Nt seq
                                  • AYV61414.1
                                  • nybM
                                  		 17565 - 18629 (+) acetoacetyl-CoA synthase
                                    copy AA seq
                                    copy Nt seq
                                    • AYV61415.1
                                    • nybN
                                    		 18685 - 19233 (+) aromatase/cyclase
                                      copy AA seq
                                      copy Nt seq
                                      • AYV61416.1
                                      • nybO
                                      		 19275 - 20927 (+) long-chain acyl-CoA synthetase
                                        copy AA seq
                                        copy Nt seq
                                        • AYV61417.1
                                        • nybP
                                        		 20924 - 22354 (+) salicylate hydroxylase
                                          copy AA seq
                                          copy Nt seq
                                          • AYV61418.1
                                          • nybQ
                                          		 22631 - 23761 (-) hypothetical protein
                                            copy AA seq
                                            copy Nt seq
                                            • AYV61419.1
                                            • nybR
                                            		 23974 - 24690 (-) NAD-dependent epimerase
                                              copy AA seq
                                              copy Nt seq
                                              • AYV61420.1
                                              • nybS
                                              		 24757 - 25518 (-) SAM-dependent methyltransferase
                                                copy AA seq
                                                copy Nt seq
                                                • AYV61421.1
                                                • nybT
                                                		 25626 - 26624 (-) isopenicillin N synthase family oxygenase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • AYV61422.1
                                                  • nybU
                                                  		 26908 - 27933 (-) isopenicillin N synthase family oxygenase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • AYV61423.1
                                                    • nybV
                                                    		 27992 - 29476 (-) MFS transporter
                                                      copy AA seq
                                                      copy Nt seq
                                                      • AYV61424.1
                                                      • nybW
                                                      		 29762 - 30490 (+) transcriptional regulator
                                                        copy AA seq
                                                        copy Nt seq
                                                        Biosynthesis information
                                                        Annotation changelog

                                                        Entry version: 3

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Cleaned up synonym list
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Fetch compound properties from PubChem
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Updated bioactivity data
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2019-10-16
                                                        Submitted
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        Similar known gene clusters from MIBiG 4.0
                                                        Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                        Click on reference genes to show details of similarities to genes within the current region.
                                                        Click on an accession to open that entry in the MiBIG database.