BGC0001967: acyldepsipeptide 1 biosynthetic gene cluster from Streptomyces hawaiiensis
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Location: 1 - 36,600 nt. (total: 36,600 nt).
This entry is originally from NCBI GenBank MK047367.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001967
Short description acyldepsipeptide 1 biosynthetic gene cluster from Streptomyces hawaiiensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Polyene)
Loci NCBI GenBank: MK047367.1
Compounds
  • acyldepsipeptide 1
Species Streptomyces hawaiiensis [taxonomy]
References
Chemical products information
acyldepsipeptide 1
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QED88045.1
 297 - 1463 (-) putative regulator component
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  • QED88046.1
 1450 - 1971 (-) putative regulator component
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  • QED88047.1
 2211 - 2717 (-) putative XRE family transcriptional regulator
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  • QED88048.1
  • adeA
 3393 - 4217 (+) leucine hydroxylase
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  • QED88049.1
  • adeB
 4214 - 5329 (+) alcohol dehydrogenase
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  • QED88050.1
  • adeC
 5958 - 6218 (+) acyl carrier protein
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  • QED88051.1
  • adeD
 6258 - 7520 (+) 3-oxoacyl-ACP synthase alpha
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  • QED88052.1
  • adeE
 7517 - 8638 (+) 3-oxoacyl-ACP synthase beta
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  • QED88053.1
  • adeF
 8635 - 9420 (+) 3-oxoacyl-ACP reductase
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  • QED88054.1
  • adeG
 9456 - 23465 (+) nonribosomal peptide synthetase
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  • QED88055.1
  • adeH
 23462 - 30604 (+) nonribosomal peptide synthetase
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  • QED88056.1
  • adeI
 30635 - 30871 (+) MbtH-like protein
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  • QED88057.1
 30990 - 31676 (+) transposase
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  • QED88058.1
 31807 - 32076 (+) hypothetical protein
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  • QED88059.1
 32164 - 32742 (-) transposase
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  • QED88060.1
 33112 - 33627 (+) transposase
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  • QED88061.1
 34138 - 34443 (+) transposase
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  • QED88062.1
 34464 - 35069 (-) hypothetical protein
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  • QED88063.1
  • clpPADEP
 35713 - 36333 (+) ClpPADEP
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Polyketide-specific information
Subclass Polyene
Cyclic? no
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
adeG
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: proline
Evidence for specificity:
  • Enzyme-coupled assay
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
adeH
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: proline / 4R-methylproline
Evidence for specificity:
  • Enzyme-coupled assay
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: CUSGWVK3I4TVHJH7NHPFAP2L, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fixed DOIs
  • Added missing polyketide class
  • Added polyene subclass
  • Use PubMed reference instead of DOI
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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