BGC0001967 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001967 (Streptomyces hawaiiensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,ladderane	1	36,600	pepticinnamin E	NRP + Polyketide	30%

BGC0001967 - Region 1 - NRPS,ladderane

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Location: 1 - 36,600 nt. (total: 36,600 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
ladderane: ladderane

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 36,601
Label		BGC0001967

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001967.1	1.61	NRP	acyldepsipeptide 1	Streptomyces hawaiiensis
BGC0001185.1	0.66	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001833.1	0.65	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002071.1	0.64	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000401.1	0.64	NRP	paenibactin	Paenibacillus elgii B69
BGC0000389.1	0.64	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001844.1	0.63	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.61	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001050.1	0.61	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001128.1	0.61	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001967.1	0.98	NRP	acyldepsipeptide 1	Streptomyces hawaiiensis
BGC0002071.1	0.73	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000389.1	0.73	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001185.1	0.70	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001050.1	0.70	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000401.1	0.69	NRP	paenibactin	Paenibacillus elgii B69
BGC0001833.1	0.68	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001615.1	0.67	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001844.1	0.67	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000465.1	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 36600:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (phe - ser - pro - NMe-ala) + (ala - pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

adeG

Search NORINE for peptide: strict or relaxed

AMP-binding (474..870): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTVAAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 100% (strong)

AMP-binding (1529..1938): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHISLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (2597..3006): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DVQYgAHVVK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 90% (moderate)

AMP-binding (3668..4063): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DvfSvAiVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 60% (weak)

adeH

Search NORINE for peptide: strict or relaxed

AMP-binding (471..866): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DvfSvAiVYK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 60% (weak)

AMP-binding (1528..1937): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DvQYgGHLVK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 80% (moderate)