BGC0002024: nargenicin A1 biosynthetic gene cluster from Nocardia argentinensis
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Location: 1 - 69,359 nt. (total: 69,359 nt).
This entry is originally from NCBI GenBank MH544245.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002024
Short description nargenicin A1 biosynthetic gene cluster from Nocardia argentinensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
MH544245.1
via
Compounds
  • nargenicin A1
  • nargenicin A1
Species Nocardia argentinensis [taxonomy]
References
Chemical products information
nargenicin A1 [synonyms: CP-47, 444] Evidence:
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C28H37N1O8
Chemical database entries
PubCHEM
nargenicin A1 Evidence:
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AXG22400.1
 1 - 183 (-) hypothetical protein
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    • AXG22401.1
    		 309 - 620 (+) hypothetical protein
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      • AXG22402.1
      		 652 - 4212 (-) DNA polymerase III subunit alpha
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        • AXG22403.1
        • ngnE
        		 4339 - 5118 (-) thioesterase
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          • AXG22404.1
          • ngnD
          		 5198 - 5656 (-) nuclear transport factor 2 family protein
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            • AXG22405.1
            • ngnC
            		 5653 - 16644 (-) type I polyketide synthase
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              • AXG22406.1
              • ngnB
              		 16660 - 30948 (-) type I polyketide synthase
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                • AXG22407.1
                • ngnA
                		 30996 - 48881 (-) type I polyketide synthase
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                  • AXG22408.1
                  • ngnK
                  		 49202 - 50248 (-) L-glyceraldehyde 3-phosphate reductase
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                    • AXG22409.1
                    • ngnP1
                    		 50439 - 51701 (+) cytochrome P450
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                      • AXG22410.1
                      • ngnO2
                      		 51720 - 52985 (+) pristinamycin IIA synthase subunit A
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                        • AXG22411.1
                        • ngnO1
                        		 52982 - 53914 (+) LLM class flavin-dependent oxidoreductase
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                          • AXG22412.1
                          • ngnG
                          		 53952 - 54794 (+) short-chain dehydrogenase
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                            • AXG22413.1
                            • ngnM
                            		 54856 - 55692 (-) methyltransferase
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                              • AXG22414.1
                              • ngnF
                              		 55721 - 55918 (-) ferredoxin
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                                • AXG22415.1
                                • ngnP2
                                		 55925 - 57142 (-) Cytochrome P450
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                                  • AXG22416.1
                                  • ngnO3
                                  		 57330 - 58127 (+) Phytanoyl-CoA dioxygenase
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                                    • AXG22417.1
                                    • ngnI
                                    		 58153 - 59079 (+) retinol dehydrogenase
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                                      • AXG22418.1
                                      • ngnJ
                                      		 59093 - 60040 (-) LysR family transcriptional regulator
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                                        • AXG22419.1
                                        • ngnN5
                                        		 61174 - 61449 (-) proline carrier protein
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                                          • AXG22420.1
                                          • ngnN4
                                          		 61388 - 62950 (-) proline adenyltransferase
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                                            • AXG22421.1
                                            • ngnN3
                                            		 62947 - 64074 (-) prolyl carrier protein dehydrogenase
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                                              • AXG22422.1
                                              • ngnN2
                                              		 64355 - 65332 (+) keto-acyl ACP-synthase
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                                                • AXG22423.1
                                                		 65890 - 67326 (+) peptidase M14
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                                                  • AXG22424.1
                                                  		 67693 - 68781 (+) GGDEF domain-containing protein
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                                                    • AXG22425.1
                                                    		 68820 - 69359 (+) acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
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                                                      Biosynthesis information
                                                      Annotation changelog

                                                      Entry version: next

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2024-08-09
                                                      MIBiG v4 annotathon
                                                      • (ID: YO3TP6VWB5CBNPZKNYNQSKUW)
                                                      • (ID: M4JYS7EJ6SF34AKXEWFIK3JY)
                                                      • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Added AMP-binding domain substrate specificities
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2019-10-16
                                                      Submitted
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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