BGC0002046: lobatamide A biosynthetic gene cluster from Gynuella sunshinyii YC6258
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 3,757,939 - 3,827,497 nt. (total: 69,559 nt).
This entry is originally from NCBI GenBank CP007142.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002046
Short description lobatamide A biosynthetic gene cluster from Gynuella sunshinyii YC6258
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Macrolide)
Loci NCBI GenBank: CP007142.1
Compounds
  • lobatamide A
Species Gynuella sunshinyii YC6258 [taxonomy]
References
Chemical products information
lobatamide A
Copy SMILES
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • YC6258_03634
  • AJQ95670.1
 3757939 - 3758403 (+) methyl-accepting chemotaxis protein
copy AA seq
copy Nt seq
  • YC6258_03635
  • AJQ95671.1
 3758377 - 3758529 (-) hypothetical Protein
copy AA seq
copy Nt seq
  • YC6258_03636
  • AJQ95672.1
 3758545 - 3759483 (-) putative permease, DMT superfamily
copy AA seq
copy Nt seq
  • YC6258_03637
  • AJQ95673.1
 3759644 - 3760522 (+) transcriptional regulator
copy AA seq
copy Nt seq
  • YC6258_03638
  • AJQ95674.1
 3760544 - 3764008 (-) polyketide synthase modules-related protein
copy AA seq
copy Nt seq
  • YC6258_03639
  • AJQ95675.1
 3764020 - 3774951 (-) polyketide synthase modules-related protein
copy AA seq
copy Nt seq
  • YC6258_03640
  • AJQ95676.1
 3774948 - 3791723 (-) polyketide synthase modules-related protein
copy AA seq
copy Nt seq
  • YC6258_03641
  • AJQ95677.1
 3791794 - 3802590 (-) polyketide synthase modules-related protein
copy AA seq
copy Nt seq
  • YC6258_03642
  • AJQ95678.1
 3802590 - 3816992 (-) polyketide synthase modules-related protein
copy AA seq
copy Nt seq
  • YC6258_03643
  • AJQ95679.1
 3817855 - 3818040 (-) hypothetical Protein
copy AA seq
copy Nt seq
  • YC6258_03644
  • AJQ95680.1
 3818284 - 3818715 (-) acetyltransferase
copy AA seq
copy Nt seq
  • YC6258_03645
  • AJQ95681.1
 3819040 - 3819201 (+) hypothetical Protein
copy AA seq
copy Nt seq
  • YC6258_03646
  • AJQ95682.1
 3819515 - 3820042 (-) adenylate kinase and related kinase
copy AA seq
copy Nt seq
  • YC6258_03647
  • AJQ95683.1
 3820112 - 3820573 (-) putative acetyltransferase
copy AA seq
copy Nt seq
  • YC6258_03648
  • AJQ95684.1
 3820821 - 3820952 (+) hypothetical Protein
copy AA seq
copy Nt seq
  • YC6258_03649
  • AJQ95685.1
 3821103 - 3821957 (-) NAD-dependent protein deacetylase, SIR2 family
copy AA seq
copy Nt seq
  • YC6258_03650
  • AJQ95686.1
 3821945 - 3822841 (-) putative phosphatase, C-terminal domain of histone macroH2A1-like protein
copy AA seq
copy Nt seq
  • YC6258_03651
  • AJQ95687.1
 3822904 - 3823698 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_03652
  • AJQ95688.1
 3823889 - 3824761 (-) araC-type DNA-binding domain-containing protein
copy AA seq
copy Nt seq
  • YC6258_03653
  • AJQ95689.1
 3825530 - 3826501 (-) nucleoside-diphosphate-sugar epimerase
copy AA seq
copy Nt seq
  • YC6258_03654
  • AJQ95690.1
 3826514 - 3827497 (-) 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Macrolide
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
YC6258_03638
+
YC6258_03639
+
YC6258_03640
+
YC6258_03641
+
YC6258_03642 		Synthase subclass: Trans-AT type I
Module 1
Genes: YC6258_03642
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Oxidation
Non-canonical activity:
  • Non-elongating
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 2
Genes: YC6258_03642
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Non-canonical activity:
  • Non-elongating
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 3
Genes: YC6258_03642
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Genes: YC6258_03642, YC6258_03641
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 6
Genes: YC6258_03641
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: YC6258_03641, YC6258_03640
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 8
Genes: YC6258_03640
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation, Oxidation
Module 9
Genes: YC6258_03640
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 10
Genes: YC6258_03640, YC6258_03639
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 11
Genes: YC6258_03639
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 12
Genes: YC6258_03639
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 13
Genes: YC6258_03639
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 14
Genes: YC6258_03638
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP), Thioesterase
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
YC6258_03642
Module 0
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
YC6258_03641
Module 4
Module 5
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: 6CMFYLN6YIRYRVG5SRRBZ7FY, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Submitted
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Changed polyketide information to that described by reference paper
  • Added version to NCBI accession
  • Switch to GenBank reference/identifiers
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.