BGC0002056 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002056 (sponge metagenome)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	transAT-PKS-like	1	53,043	High	peloruside A	NRPS:Type I+PKS:Trans-AT type I

BGC0002056 - Region 1 - transAT-PKS-like

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Location: 1 - 53,043 nt. (total: 53,043 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 53,044
Label		BGC0002056

Tailoring functions

Transferases: methyltransferase

pelD: methyltransferase

smcogs: SMCOG1089: methyltransferase

Ligases: ligase

pelB: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

pelC: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002056.3	0.94	NRPS, PKS	peloruside A	sponge metagenome
BGC0001109.4	0.50	NRPS, PKS	pederin	unidentified unclassified sequences.
BGC0001108.5	0.48	NRPS, PKS	pederin, pseudopederin, pederone	Uncultured bacterium
BGC0000083.5	0.48	PKS	lactimidomycin, 8,9-dihydrolactimidomycin, 8-hydroxy-8,9-dihydrolactidomycin, 17-hydroxy-8-desmethoxy-isomigrastatin	Streptomyces amphibiosporus
BGC0002046.3	0.48	NRPS, PKS	lobatamide A	Gynuella sunshinyii YC6258
BGC0001656.3	0.47	PKS	luminaolide , luminaolide B	Planktothrix paucivesiculata PCC 9631
BGC0000185.5	0.47	PKS	tartrolon D, tartrolon E	Teredinibacter turnerae T7901
BGC0001186.4	0.47	PKS	misakinolide A	Candidatus Entotheonella serta
BGC0002083.3	0.46	PKS	gladiofungin A, gladiofungin B	Burkholderia gladioli
BGC0000180.5	0.46	PKS	legioliulin	Legionella parisiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002056.3	0.94	NRPS, PKS	peloruside A	sponge metagenome
BGC0001109.4	0.50	NRPS, PKS	pederin	unidentified unclassified sequences.
BGC0001108.5	0.48	NRPS, PKS	pederin, pseudopederin, pederone	Uncultured bacterium
BGC0000083.5	0.48	PKS	lactimidomycin, 8,9-dihydrolactimidomycin, 8-hydroxy-8,9-dihydrolactidomycin, 17-hydroxy-8-desmethoxy-isomigrastatin	Streptomyces amphibiosporus
BGC0002046.3	0.48	NRPS, PKS	lobatamide A	Gynuella sunshinyii YC6258
BGC0001656.3	0.47	PKS	luminaolide , luminaolide B	Planktothrix paucivesiculata PCC 9631
BGC0000185.5	0.47	PKS	tartrolon D, tartrolon E	Teredinibacter turnerae T7901
BGC0001186.4	0.47	PKS	misakinolide A	Candidatus Entotheonella serta
BGC0002083.3	0.46	PKS	gladiofungin A, gladiofungin B	Burkholderia gladioli
BGC0000180.5	0.46	PKS	legioliulin	Legionella parisiensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 53043:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal - mal - mal - ccmal - ohmal - OMe-mal) + (Me-ohmal - mal - ohmal - OMe-mal - ohmal - ohmal)
Non-colinear ordering:: pelC + pelD

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

pelB: X

AMP-binding (8..355): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LGNPTGTALK
Nearest Stachelhaus code(s):: 2,3-dohHda IGNPTGTIMK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor