BGC0002063: cryptosporioptide B biosynthetic gene cluster from Cryptosporiopsis sp. 8999
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Location: 1 - 82,565 nt. (total: 82,565 nt).
This entry is originally from NCBI GenBank MK182094.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002063
Short description cryptosporioptide B biosynthetic gene cluster from Cryptosporiopsis sp. 8999
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
MK182094.1
via Knock-out studies
Compounds
  • cryptosporioptide B
  • cryptosporioptide A
  • cryptosporioptide C
Species Cryptosporiopsis sp. 8999 [taxonomy]
References
Chemical products information
cryptosporioptide B Evidence: NMR, Mass spectrometry
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C38H34O18
Chemical database entries
NPAtlas
cryptosporioptide A Evidence: NMR, Mass spectrometry
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C36H30O18
Chemical database entries
NPAtlas
cryptosporioptide C Evidence: NMR, Mass spectrometry
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C40H38O18
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QCL09086.1
  • dmxL5
 112 - 1344 (+) DmxL5
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    • QCL09087.1
    • dmxL4
    		 1662 - 3074 (-) DmxL4
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      • QCL09088.1
      • dmxL3
      		 7874 - 9607 (-) DmxL3
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        • QCL09089.1
        • dmxL2
        		 15492 - 22909 (-) dmxL2
        • Scaffold biosynthesis
        • Knock-out
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        • QCL09090.1
        • dmxL1
        		 24449 - 31589 (+) dmxL1
        • Tailoring
        • Knock-out
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        • QCL09091.1
        • dmx-nrPKS
        		 34996 - 40852 (-) dmx-nrPKS
        • Scaffold biosynthesis
        • Knock-out
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        • QCL09092.1
        • dmxR1
        		 41704 - 42881 (+) DmxR1
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          • QCL09093.1
          • dmxR2
          		 43730 - 45420 (+) DmxR2
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            • QCL09094.1
            • dmxR3
            		 45901 - 46685 (-) DmxR3
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              • QCL09095.1
              • dmxR4
              		 48612 - 50668 (-) DmxR4
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                • QCL09096.1
                • dmxR5
                		 51449 - 53114 (+) dmxR5
                • Tailoring
                • Knock-out
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                • QCL09097.1
                • dmxR6
                		 54723 - 56063 (+) dmxR6
                • Tailoring
                • Knock-out
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                • QCL09098.1
                • dmxR7
                		 56646 - 57384 (-) DmxR7
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                  • QCL09099.1
                  • dmxR8
                  		 58130 - 59104 (+) DmxR8
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                    • QCL09100.1
                    • dmxR9
                    		 59271 - 60880 (-) DmxR9
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                      • QCL09101.1
                      • dmxR10
                      		 61760 - 62312 (+) DmxR10
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                        • QCL09102.1
                        • dmxR11
                        		 63686 - 64547 (+) DmxR11
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                          • QCL09103.1
                          • dmxR12
                          		 66051 - 66885 (+) DmxR12
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                            • QCL09104.1
                            • dmxR13
                            		 67908 - 69284 (-) dmxR13
                            • Tailoring
                            • Knock-out
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                            • QCL09105.1
                            • dmxR14
                            		 69696 - 71070 (+) DmxR14
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                              • QCL09106.1
                              • dmxR15
                              		 71630 - 72494 (-) DmxR15
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                                • QCL09107.1
                                • dmxR16
                                		 72957 - 73512 (+) DmxR16
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                                  • QCL09108.1
                                  • dmxR17
                                  		 74206 - 74834 (-) DmxR17
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                                    • QCL09109.1
                                    • dmxR18
                                    		 75451 - 76370 (+) DmxR18
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                                      • QCL09110.1
                                      • dmxR19
                                      		 77484 - 79078 (-) DmxR19
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                                        • QCL09111.1
                                        • dmxR20
                                        		 79688 - 81541 (-) DmxR20
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                                          Biosynthesis information

                                          Biosynthetic modules

                                          Name
                                          1
                                          Type
                                          pks-modular
                                          Genes
                                          dmx-nrPKS
                                          Substrates
                                          Integrated Monomers
                                          Domains
                                          acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                          Name
                                          2
                                          Type
                                          pks-modular
                                          Genes
                                          dmxL2
                                          Substrates
                                          Integrated Monomers
                                          Domains
                                          acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                          Annotation changelog

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-10-07
                                          Update chemical activity to schema version 2.11
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Submitted
                                          • (ID: 5B66KLYJNZGZOCCCX4CRFPVL)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Added version to NCBI accession
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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