BGC0002063: cryptosporioptide B biosynthetic gene cluster from Cryptosporiopsis sp. 8999
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Location: 1 - 82,565 nt. (total: 82,565 nt).
This entry is originally from NCBI GenBank MK182094.1.

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core biosynthetic genes
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General
Compounds
Genes
Polyketide
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002063
Short description cryptosporioptide B biosynthetic gene cluster from Cryptosporiopsis sp. 8999
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: MK182094.1
Compounds
  • cryptosporioptide B
  • cryptosporioptide A
  • cryptosporioptide C
Species Cryptosporiopsis sp. 8999 [taxonomy]
References
Chemical products information
cryptosporioptide B
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C38H34O18
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NPAtlas
cryptosporioptide A
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C36H30O18
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NPAtlas
cryptosporioptide C
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C40H38O18
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QCL09086.1
  • dmxL5
 112 - 1344 (+) DmxL5
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  • QCL09087.1
  • dmxL4
 1662 - 3074 (-) DmxL4
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  • QCL09088.1
  • dmxL3
 7874 - 9607 (-) DmxL3
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  • QCL09089.1
  • dmxL2
 15492 - 22909 (-) dmxL2
  • Scaffold biosynthesis
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  • QCL09090.1
  • dmxL1
 24449 - 31589 (+) dmxL1
  • Tailoring (Carboxylation)
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  • QCL09091.1
  • dmx-nrPKS
 34996 - 40852 (-) dmx-nrPKS
  • Scaffold biosynthesis
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  • QCL09092.1
  • dmxR1
 41704 - 42881 (+) DmxR1
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  • QCL09093.1
  • dmxR2
 43730 - 45420 (+) DmxR2
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  • QCL09094.1
  • dmxR3
 45901 - 46685 (-) DmxR3
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  • QCL09095.1
  • dmxR4
 48612 - 50668 (-) DmxR4
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  • QCL09096.1
  • dmxR5
 51449 - 53114 (+) dmxR5
  • Tailoring (Unknown)
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  • QCL09097.1
  • dmxR6
 54723 - 56063 (+) dmxR6
  • Tailoring (Oxidation)
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  • QCL09098.1
  • dmxR7
 56646 - 57384 (-) DmxR7
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  • QCL09099.1
  • dmxR8
 58130 - 59104 (+) DmxR8
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  • QCL09100.1
  • dmxR9
 59271 - 60880 (-) DmxR9
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  • QCL09101.1
  • dmxR10
 61760 - 62312 (+) DmxR10
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  • QCL09102.1
  • dmxR11
 63686 - 64547 (+) DmxR11
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  • QCL09103.1
  • dmxR12
 66051 - 66885 (+) DmxR12
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  • QCL09104.1
  • dmxR13
 67908 - 69284 (-) dmxR13
  • Tailoring (Acylation)
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  • QCL09105.1
  • dmxR14
 69696 - 71070 (+) DmxR14
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  • QCL09106.1
  • dmxR15
 71630 - 72494 (-) DmxR15
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  • QCL09107.1
  • dmxR16
 72957 - 73512 (+) DmxR16
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  • QCL09108.1
  • dmxR17
 74206 - 74834 (-) DmxR17
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  • QCL09109.1
  • dmxR18
 75451 - 76370 (+) DmxR18
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  • QCL09110.1
  • dmxR19
 77484 - 79078 (-) DmxR19
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  • QCL09111.1
  • dmxR20
 79688 - 81541 (-) DmxR20
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
dmxL2
+
dmx-nrPKS 		Synthase subclass: Iterative type I
Iterative PKS type: Non-reducing, C6-C11 first
Iteration counts: 8
Module 1
Genes: dmx-nrPKS
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 2
Genes: dmxL2
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: 5B66KLYJNZGZOCCCX4CRFPVL, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Added version to NCBI accession
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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