BGC0002063 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002063 (Cryptosporiopsis sp. 8999)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	82,565	neosartorin	Polyketide	68%

BGC0002063 - Region 1 - T1PKS

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Location: 1 - 82,565 nt. (total: 82,565 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 82,566
Label		BGC0002063

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002063.1	0.80	Polyketide	cryptosporioptide A, cryptosporioptide B, cryptosporioptide C	Cryptosporiopsis sp. 8999
BGC0001858.1	0.32	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000688.1	0.29	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001068.1	0.28	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001280.1	0.27	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.27	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000013.1	0.27	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001141.1	0.26	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0000676.1	0.26	Terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0000003.1	0.25	Polyketide	AF-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002063.1	0.94	Polyketide	cryptosporioptide A, cryptosporioptide B, cryptosporioptide C	Cryptosporiopsis sp. 8999
BGC0001858.1	0.65	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000688.1	0.62	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001068.1	0.62	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001280.1	0.61	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.61	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000013.1	0.60	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001141.1	0.59	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0000676.1	0.59	Terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0000003.1	0.58	Polyketide	AF-toxin	Alternaria alternata

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 60852:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: dmxL2 + dmx-nrPKS

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

dmxL2

PKS_AT (574..892): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 71.0
Methoxymalonyl-CoA: 69.3
Malonyl-CoA: 52.4
Isobutyryl-CoA: 45.3
trans-1,2-CPDA: 36.6
2-Methylbutyryl-CoA: 32.4
Propionyl-CoA: 28.8
CHC-CoA: 23.3
Benzoyl-CoA: 22.4
fatty_acid: 14.6
Acetyl-CoA: 12.4
inactive: 12.1
3-Methylbutyryl-CoA: 10.6
Ethylmalonyl-CoA: -0.6

dmx-nrPKS

PKS_AT (926..1225): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.9
inactive: 57.2
Methylmalonyl-CoA: 54.8
Methoxymalonyl-CoA: 47.9
Propionyl-CoA: 39.3
fatty_acid: 28.2
Ethylmalonyl-CoA: 24.4
2-Methylbutyryl-CoA: 24.2
Benzoyl-CoA: 23.1
Isobutyryl-CoA: 18.3
CHC-CoA: 17.5
Acetyl-CoA: 14.9
trans-1,2-CPDA: 10.8
3-Methylbutyryl-CoA: 9.6