BGC0002072: linearmycin A biosynthetic gene cluster from Streptomyces sp. Mg1
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Location: 1,061,319 - 1,236,790 nt. (total: 175,472 nt).
This entry is originally from NCBI GenBank CP011664.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002072
Short description linearmycin A biosynthetic gene cluster from Streptomyces sp. Mg1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
CP011664.1
1061319 - 1236790
via Knock-out studies
Compounds
  • linearmycin A
  • linearmycin B
  • linearmycin C
  • linearmycin C
Species Streptomyces sp. Mg1 [taxonomy]
References
Chemical products information
linearmycin A Evidence: NMR, Mass spectrometry
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Chemical database entries
PubCHEM
NPAtlas
linearmycin B Evidence: NMR, Mass spectrometry
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Chemical database entries
PubCHEM
NPAtlas
linearmycin C Evidence: NMR, Mass spectrometry
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Chemical database entries
PubCHEM
NPAtlas
linearmycin C Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • M444_04750
  • AKL64821.1
  • lnyT
 1061319 - 1062308 (-) agmatinase
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    • M444_04755
    • AKL64822.1
    • lnyS
    		 1062415 - 1063971 (-) methylmalonyl-CoA carboxyltransferase
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      • M444_04760
      • AMB20391.1
      • lnyR
      		 1064457 - 1067375 (+) transcriptional regulator
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        • M444_04765
        • AKL64823.1
        • lnyQ
        		 1067356 - 1068252 (+) metallophosphoesterase
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          • M444_04770
          • AKL64824.1
          • lnyP
          		 1068249 - 1068992 (+) 4'-phosphopantetheinyl transferase
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            • M444_04775
            • AKL64825.1
            • lnyO
            		 1069184 - 1070845 (+) amine oxidase
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              • M444_04780
              • AKL64826.1
              • lnyN
              		 1070939 - 1072351 (-) acyl--CoA ligase
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                • M444_04785
                • AKL69762.1
                • lnyM
                		 1072435 - 1073028 (-) thioesterase
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                  • M444_04790
                  • AMB20392.1
                  • lnyL
                  		 1073166 - 1073738 (-) glucose-1-phosphate thymidylyltransferase
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                    • M444_04795
                    • AKL64827.1
                    • lnyK
                    		 1074063 - 1075127 (+) daunorubicin ABC transporter ATPase
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                      • M444_04800
                      • AKL69763.1
                      • lnyJ
                      		 1075226 - 1075996 (+) ABC transporter
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                        • M444_04805
                        • AKL64828.1
                        • lnyI
                        		 1076160 - 1077197 (+) ACP S-malonyltransferase
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                          • M444_04810
                          • AMB20393.1
                          • lnyHI
                          		 1077302 - 1094107 (-) polyketide synthase
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                            • M444_04815
                            • AKL64829.1
                            • lnyHH
                            		 1094175 - 1116644 (-) polyketide synthase
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                              • M444_04820
                              • AKL64830.1
                              • lnyHG
                              		 1116707 - 1126318 (-) polyketide synthase
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                                • M444_04825
                                • AKL64831.1
                                • lnyHF
                                		 1126413 - 1142603 (-) polyketide synthase
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                                  • M444_04830
                                  • AMB20394.1
                                  • lnyHE
                                  		 1142689 - 1158345 (-) polyketide synthase
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                                    • M444_04835
                                    • AKL64832.1
                                    • lnyHD
                                    		 1158599 - 1163497 (-) polyketide synthase
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                                      • M444_04840
                                      • AKL64833.1
                                      • lnyHC
                                      		 1163620 - 1183653 (-) polyketide synthase
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                                        • M444_04845
                                        • AKL69764.1
                                        • lnyHB
                                        		 1183678 - 1193985 (-) polyketide synthase
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                                          • M444_04850
                                          • AKL64834.1
                                          • lnyHA
                                          		 1194150 - 1228586 (-) polyketide synthase
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                                            • M444_04855
                                            • AKL64835.1
                                            • lnyG
                                            		 1228902 - 1230452 (-) membrane protein
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                                              • M444_04860
                                              • AKL69765.1
                                              • lnyF
                                              		 1230449 - 1230949 (-) membrane protein
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                                                • M444_04865
                                                • AKL64836.1
                                                • lnyE
                                                		 1231012 - 1231545 (-) LnyE
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                                                  • M444_04870
                                                  • AKL64837.1
                                                  • lnyD
                                                  		 1231711 - 1233006 (+) histidine kinase
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                                                    • M444_04875
                                                    • AKL69766.1
                                                    • lnyC
                                                    		 1233071 - 1233631 (+) LuxR family transcriptional regulator
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                                                      • M444_04880
                                                      • AKL69767.1
                                                      • lnyB
                                                      		 1233701 - 1236565 (-) transcriptional regulator
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                                                        Biosynthesis information

                                                        Biosynthetic modules

                                                        Name
                                                        1
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHA
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP), carrier (ACP)
                                                        Name
                                                        2
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHA
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        3
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHA
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        4
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHA
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        5
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHA
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        6
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHA
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        7
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHA
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        8
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHB
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        9
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHB
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        10
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHC
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        11
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHC
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        12
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHC
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        13
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHC
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        14
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHD
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        15
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHE
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        16
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHE
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        17
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHE
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        18
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHF
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        19
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHF
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        20
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHF
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        21
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHG
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        22
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHG
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                        Name
                                                        23
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHH
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        24
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHH
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                        Name
                                                        25
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHH
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        26
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHH
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        27
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHI
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        28
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHI
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                        Name
                                                        29
                                                        Type
                                                        pks-modular
                                                        Genes
                                                        lnyHI
                                                        Substrates
                                                        Integrated Monomers
                                                        Domains
                                                        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, thioesterase, carrier (ACP)
                                                        Annotation changelog

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-10-07
                                                        Added chemical structures for compounds: linearmycin C.
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-10-07
                                                        Added NPAtlas links to compounds: linearmycin C.
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Submitted
                                                        • (ID: R7Q3ADVMVK5DLOD43C64GWJ2)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Added version to NCBI accession
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        Detailed domain annotation
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