BGC0002086 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002086 (Micromonospora carbonacea)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	60,202	tylactone	Polyketide	65%

BGC0002086 - Region 1 - T1PKS

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Location: 1 - 60,202 nt. (total: 60,202 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 60,203
Label		BGC0002086

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002086.1	1.00	Polyketide	rosamicin	Micromonospora carbonacea
BGC0001812.1	0.70	Polyketide	tylactone	Micromonospora chalcea subsp. izumensis
BGC0000018.1	0.48	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000113.1	0.41	Polyketide	niddamycin	Streptomyces caelestis
BGC0001830.1	0.39	Polyketide	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0000041.1	0.36	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276.1	0.34	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.34	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.34	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000067.1	0.33	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002086.1	1.00	Polyketide	rosamicin	Micromonospora carbonacea
BGC0001812.1	0.89	Polyketide	tylactone	Micromonospora chalcea subsp. izumensis
BGC0000018.1	0.77	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000113.1	0.73	Polyketide	niddamycin	Streptomyces caelestis
BGC0001830.1	0.71	Polyketide	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0000041.1	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276.1	0.67	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.67	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000067.1	0.67	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 60202:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ohmal - Me-ccmal) + (Me-ohmal) + (ccmal) + (Me-ohmal - redemal) + (ohmal)
Non-colinear ordering:: HXZ27_06120 + HXZ27_06135 + HXZ27_06125 + HXZ27_06130 + HXZ27_06140

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

HXZ27_06120

PKS_AT (569..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.0
Ethylmalonyl-CoA: 168.4
Methoxymalonyl-CoA: 150.4
2-Methylbutyryl-CoA: 122.7
trans-1,2-CPDA: 101.8
Propionyl-CoA: 91.9
Malonyl-CoA: 82.1
Isobutyryl-CoA: 78.1
CHC-CoA: 73.3
Benzoyl-CoA: 67.4
Acetyl-CoA: 36.9
inactive: 27.6
fatty_acid: 24.2
3-Methylbutyryl-CoA: 12.0

PKS_AT (1598..1898): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.0
Ethylmalonyl-CoA: 170.6
Methoxymalonyl-CoA: 153.2
2-Methylbutyryl-CoA: 120.1
trans-1,2-CPDA: 102.9
Propionyl-CoA: 91.6
Malonyl-CoA: 81.7
Isobutyryl-CoA: 80.3
CHC-CoA: 74.3
Benzoyl-CoA: 69.0
Acetyl-CoA: 35.0
inactive: 29.5
fatty_acid: 24.3
3-Methylbutyryl-CoA: 13.7

PKS_AT (3118..3418): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.0
Ethylmalonyl-CoA: 170.6
Methoxymalonyl-CoA: 153.2
2-Methylbutyryl-CoA: 120.1
trans-1,2-CPDA: 102.9
Propionyl-CoA: 91.6
Malonyl-CoA: 81.7
Isobutyryl-CoA: 80.3
CHC-CoA: 74.3
Benzoyl-CoA: 69.0
Acetyl-CoA: 35.0
inactive: 29.5
fatty_acid: 24.3
3-Methylbutyryl-CoA: 13.7

HXZ27_06125

PKS_AT (601..901): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.3
inactive: 107.0
Methylmalonyl-CoA: 75.2
Methoxymalonyl-CoA: 74.6
Ethylmalonyl-CoA: 44.9
Isobutyryl-CoA: 43.6
Propionyl-CoA: 31.8
CHC-CoA: 22.6
Benzoyl-CoA: 17.9
trans-1,2-CPDA: 15.7
Acetyl-CoA: 14.9
2-Methylbutyryl-CoA: 13.6
fatty_acid: 11.3
3-Methylbutyryl-CoA: 0.0

HXZ27_06130

PKS_AT (600..900): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.0
Ethylmalonyl-CoA: 170.6
Methoxymalonyl-CoA: 153.2
2-Methylbutyryl-CoA: 120.1
trans-1,2-CPDA: 102.9
Propionyl-CoA: 91.6
Malonyl-CoA: 81.7
Isobutyryl-CoA: 80.3
CHC-CoA: 74.3
Benzoyl-CoA: 69.0
Acetyl-CoA: 35.0
inactive: 29.5
fatty_acid: 24.3
3-Methylbutyryl-CoA: 13.7

PKS_AT (2123..2421): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 235.2
Methylmalonyl-CoA: 202.9
Methoxymalonyl-CoA: 180.1
trans-1,2-CPDA: 166.5
2-Methylbutyryl-CoA: 159.8
Propionyl-CoA: 121.3
CHC-CoA: 98.1
Malonyl-CoA: 83.6
Isobutyryl-CoA: 72.1
Benzoyl-CoA: 61.4
Acetyl-CoA: 59.5
fatty_acid: 48.6
3-Methylbutyryl-CoA: 34.9
inactive: 16.4

HXZ27_06135

PKS_AT (574..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.3
Ethylmalonyl-CoA: 190.5
Methoxymalonyl-CoA: 169.1
2-Methylbutyryl-CoA: 138.5
trans-1,2-CPDA: 128.2
Propionyl-CoA: 97.8
Malonyl-CoA: 85.8
CHC-CoA: 85.1
Isobutyryl-CoA: 81.2
Benzoyl-CoA: 56.3
3-Methylbutyryl-CoA: 38.3
fatty_acid: 38.2
Acetyl-CoA: 29.8
inactive: 17.5

HXZ27_06140

PKS_AT (568..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.5
inactive: 111.7
Methoxymalonyl-CoA: 60.2
Methylmalonyl-CoA: 48.9
Propionyl-CoA: 25.3
Acetyl-CoA: 18.2
Isobutyryl-CoA: 17.3
Benzoyl-CoA: 16.9
fatty_acid: 13.8
CHC-CoA: 12.0
Ethylmalonyl-CoA: 11.3
2-Methylbutyryl-CoA: 9.3
3-Methylbutyryl-CoA: 5.0
trans-1,2-CPDA: 0.0