BGC0002104: eurocidin D biosynthetic gene cluster from Streptomyces eurocidicus ATCC 27428
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 32,351 - 157,636 nt. (total: 125,286 nt).
This entry is originally from NCBI GenBank NZ_LGUI01000004.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002104
Short description eurocidin D biosynthetic gene cluster from Streptomyces eurocidicus ATCC 27428
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
NZ_LGUI01000004.1
52350 - 147183
via Gene expression correlated with compound production
Compounds
  • eurocidin D
  • eurocidin E
Species Streptomyces eurocidicus ATCC 27428 [taxonomy]
References
Chemical products information
eurocidin D Evidence: NMR, Mass spectrometry
Copy SMILES
Chemical database entries
PubCHEM
NPAtlas
eurocidin E Evidence: NMR, Mass spectrometry
Copy SMILES
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AF335_RS14695
  • WP_102918834.1
 51182 - 52354 (+) FAD-dependent monooxygenase
    copy AA seq
    copy Nt seq
    • AF335_RS14700
    • WP_102918835.1
    		 52351 - 54174 (+) amino acid adenylation domain-containing protein
      copy AA seq
      copy Nt seq
      • AF335_RS14705
      • WP_102918836.1
      		 54302 - 55009 (+) alpha/beta fold hydrolase
        copy AA seq
        copy Nt seq
        • AF335_RS14710
        • WP_102918837.1
        		 55088 - 55522 (+) Immediate-early protein 2
          copy AA seq
          copy Nt seq
          • AF335_RS14715
          • WP_102918838.1
          		 55560 - 56246 (-) DJ-1/PfpI family protein
            copy AA seq
            copy Nt seq
            • AF335_RS14720
            • WP_102918839.1
            		 56453 - 57391 (+) helix-turn-helix domain-containing protein
              copy AA seq
              copy Nt seq
              • AF335_RS14725
              • WP_102918840.1
              		 57440 - 58258 (-) SGNH/GDSL hydrolase family protein
                copy AA seq
                copy Nt seq
                • AF335_RS14730
                • WP_102918841.1
                		 58421 - 58627 (+) hypothetical protein
                  copy AA seq
                  copy Nt seq
                  • AF335_RS14735
                  • WP_102918842.1
                  		 58973 - 60010 (+) GDP-mannose 4,6-dehydratase
                    copy AA seq
                    copy Nt seq
                    • AF335_RS14740
                    • WP_102919232.1
                    		 60259 - 88761 (+) type I polyketide synthase
                      copy AA seq
                      copy Nt seq
                      • AF335_RS14745
                      • WP_102918843.1
                      		 88773 - 95162 (+) type I polyketide synthase
                        copy AA seq
                        copy Nt seq
                        • AF335_RS14750
                        • WP_102918844.1
                        		 95199 - 106361 (+) type I polyketide synthase
                          copy AA seq
                          copy Nt seq
                          • AF335_RS14755
                          • WP_102918845.1
                          		 106597 - 132054 (+) type I polyketide synthase
                            copy AA seq
                            copy Nt seq
                            • AF335_RS14760
                            • WP_102918846.1
                            		 132149 - 133006 (-) ABC transporter permease
                              copy AA seq
                              copy Nt seq
                              • AF335_RS14765
                              • WP_228773449.1
                              		 133101 - 134081 (-) ATP-binding cassette domain-containing protein
                                copy AA seq
                                copy Nt seq
                                • AF335_RS14770
                                • WP_244927023.1
                                		 134289 - 137636 (-) type I polyketide synthase
                                  copy AA seq
                                  copy Nt seq
                                  • AF335_RS14775
                                  • WP_102918848.1
                                  		 137708 - 137899 (-) ferredoxin
                                    copy AA seq
                                    copy Nt seq
                                    • AF335_RS14780
                                    • WP_102918849.1
                                    		 137976 - 139154 (-) cytochrome P450
                                      copy AA seq
                                      copy Nt seq
                                      • AF335_RS14785
                                      • WP_102918850.1
                                      		 139186 - 140244 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
                                        copy AA seq
                                        copy Nt seq
                                        • AF335_RS14790
                                        • WP_102918851.1
                                        		 140288 - 141667 (-) glycosyltransferase
                                          copy AA seq
                                          copy Nt seq
                                          • AF335_RS14795
                                          • WP_184743891.1
                                          		 142373 - 142951 (+) LuxR C-terminal-related transcriptional regulator
                                            copy AA seq
                                            copy Nt seq
                                            • AF335_RS14800
                                            • WP_102918853.1
                                            		 143060 - 144283 (-) SGNH/GDSL hydrolase family protein
                                              copy AA seq
                                              copy Nt seq
                                              • AF335_RS14805
                                              • WP_244927024.1
                                              		 144751 - 146211 (+) cytochrome P450
                                                copy AA seq
                                                copy Nt seq
                                                • AF335_RS14810
                                                • WP_184743885.1
                                                		 146390 - 146875 (-) hypothetical protein
                                                  copy AA seq
                                                  copy Nt seq
                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  1
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14740
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                  Name
                                                  2
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14740
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                  Name
                                                  3
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14740
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                  Name
                                                  4
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14740
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                  Name
                                                  5
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14740
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                  Name
                                                  6
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14740
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                  Name
                                                  7
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14745
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                  Name
                                                  8
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14750
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  9
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14750
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  10
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14755
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                  Name
                                                  11
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14755
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  12
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14755
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  13
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14755
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  14
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14755
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  15
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  AF335_RS14770
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                  Annotation changelog

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Update chemical activity to schema version 2.11
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-10-07
                                                  Changed chemical structures for compounds: eurocidin E, eurocidin D.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-10-07
                                                  Added NPAtlas links to compounds: eurocidin E, eurocidin D.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Submitted
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Fixed biosynthetic classes
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Similar known clusters from MIBiG 4.0
                                                  Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                  Detailed help and explanations are available here.

                                                  Click on reference genes to show details of similarities to genes within the current region.
                                                  Double click on a reference drawing to reverse the display of the genes.

                                                  Click on an accession to open that entry in the MIBiG database.


                                                  Location:

                                                  Identifier
                                                  Identity
                                                  Coverage
                                                  Detailed domain annotation
                                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                                  Selected features only
                                                  Show module domains