BGC0002137 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002137 (Streptomyces sp. NRRL F-3213)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,PKS-like	1	32,881	mutaxanthene A/mutaxanthene B/mutaxanthene D	PKS	100%

BGC0002137 - Region 1 - PKS-like,T2PKS

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Location: 1 - 32,881 nt. (total: 32,881 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,882
Label		BGC0002137

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002137	1.92	Polyketide	mutaxanthene A, mutaxanthene B, mutaxanthene C	Streptomyces sp. NRRL F-3213
BGC0000231	0.93	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.68	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002404	0.64	Other	falcarindiol	Solanum lycopersicum
BGC0001928	0.62	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000272	0.55	Polyketide	spore pigment	Streptomyces collinus
BGC0000888	0.54	Other	bacilysin	Bacillus sp. CS93
BGC0002069	0.51	Other (Aminocoumarin)	styrolide A, styrolide B	Pseudomonas fluorescens
BGC0001184	0.51	Other	bacilysin	Bacillus velezensis FZB42
BGC0001197	0.50	Polyketide	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002137	1.00	Polyketide	mutaxanthene A, mutaxanthene B, mutaxanthene C	Streptomyces sp. NRRL F-3213
BGC0000231	0.77	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.67	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001928	0.67	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002404	0.65	Other	falcarindiol	Solanum lycopersicum
BGC0000272	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0000888	0.61	Other	bacilysin	Bacillus sp. CS93
BGC0001184	0.61	Other	bacilysin	Bacillus velezensis FZB42
BGC0002069	0.59	Other (Aminocoumarin)	styrolide A, styrolide B	Pseudomonas fluorescens
BGC0001197	0.59	Polyketide	frankiamicin	Frankia sp. EAN1pec

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

IF70_RS33690

PKS_AT (6..296): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 58.4
Methoxymalonyl-CoA: 43.2
Methylmalonyl-CoA: 40.6
Propionyl-CoA: 22.5
3-Methylbutyryl-CoA: 16.0
inactive: 12.8
2-Methylbutyryl-CoA: 10.5
Isobutyryl-CoA: 9.2
Ethylmalonyl-CoA: 8.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0

IF70_RS33710

AMP-binding (24..408): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: PMNYLGGPLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 32881
Starter unit(s):: propionyl-CoA (Score: 702.0; E-value: 2.21e-139)
Malonyl elongations:: 8|9 (Score: 631.9; E-value: 8.4e-193)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: propionyl-CoA_8: 415 Da
propionyl-CoA_9: 457 Da

IF70_RS33690: AT (Score: 406.2; E-value: 2.4e-124); AT BAB72049.1_Aklavinone_propionyl-CoA (Score: 312.0; E-value: 1.24e-108)
IF70_RS33695: KSIII (Score: 427.3; E-value: 9.3e-131); KSIII ABC00733.1_Cosmomycin_propionyl-CoA (Score: 390.0; E-value: 2.21e-139)
IF70_RS33700: CYC C5-C14/C3-C16 (Score: 400.9; E-value: 5.2e-123)
IF70_RS33705: KR (Score: 148.7; E-value: 5.7e-46)
IF70_RS33715: CYC C7-C12 (Score: 438.5; E-value: 2.5e-134)
IF70_RS33720: KR C9 (Score: 469.3; E-value: 6.9e-144)
IF70_RS33725: OXY (Score: 172.9; E-value: 2.9e-53)
IF70_RS33735: CYC C1-C18|C2-C19 (Score: 191.5; E-value: 1.3e-59)
IF70_RS33740: KR (Score: 143.4; E-value: 2.3e-44)
IF70_RS33745: MET (Score: 259.8; E-value: 8.4e-80)
IF70_RS33755: ACP (Score: 110.0; E-value: 1e-34)
IF70_RS33760: CLF 8|9 (Score: 631.9; E-value: 8.4e-193)
IF70_RS33765: KS (Score: 745.8; E-value: 2.7e-227)
IF70_RS33775: KR (Score: 181.8; E-value: 4.6e-56)
IF70_RS33780: OXY (Score: 402.1; E-value: 8.7e-123)
IF70_RS33785: MET C2O|C2N (Score: 403.2; E-value: 1.9e-123)
IF70_RS33790: OXY (Score: 511.9; E-value: 4.3e-156)