BGC0002206 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002206 (Trichoderma guizhouense)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	63,170	High	harziphilone/t22azaphilone/isoharziphilone-1/isoharziphilone-2/compound 4/compound 1	PKS

BGC0002206 - Region 1 - T1PKS

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Location: 1 - 63,170 nt. (total: 63,170 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 63,171
Label		BGC0002206

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

A0O28_0102260: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

A0O28_0102300: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Ligases: synthase

A0O28_0102280: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

A0O28_0102340: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002206.2	1.00	PKS	harziphilone, t22azaphilone, isoharziphilone-1, isoharziphilone-2, compound 4, compound 1	Trichoderma guizhouense
BGC0002191.2	0.75	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002206.2	1.00	PKS	harziphilone, t22azaphilone, isoharziphilone-1, isoharziphilone-2, compound 4, compound 1	Trichoderma guizhouense
BGC0002191.2	0.75	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 63170:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (mal)
Non-colinear ordering:: A0O28_0102280 + A0O28_0102340

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

A0O28_0102280: pk

PKS_AT (611..945): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 60.8
Methylmalonyl-CoA: 57.8
Malonyl-CoA: 40.6
Benzoyl-CoA: 40.2
Isobutyryl-CoA: 38.5
Ethylmalonyl-CoA: 26.2
Propionyl-CoA: 23.1
trans-1,2-CPDA: 19.6
inactive: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

A0O28_0102340: mal

PKS_AT (989..1286): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 86.9
inactive: 56.1
Methoxymalonyl-CoA: 56.0
Methylmalonyl-CoA: 47.1
Ethylmalonyl-CoA: 31.4
Propionyl-CoA: 24.4
Benzoyl-CoA: 23.3
CHC-CoA: 22.8
Isobutyryl-CoA: 18.6
2-Methylbutyryl-CoA: 16.5
Acetyl-CoA: 16.4
fatty_acid: 15.0
trans-1,2-CPDA: 13.7
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor