BGC0002226 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002226 (Aspergillus aculeatus ATCC 16872)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,indole	1	48,062	High	acu-dioxomorpholine B/acu-dioxomorpholine A	NRPS:Type I

BGC0002226 - Region 1 - NRPS,indole

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Location: 1 - 48,062 nt. (total: 48,062 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 48,063
Label		BGC0002226

Tailoring functions

Lyases: dehydratase

ASPACDRAFT_46596: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase

ASPACDRAFT_46595: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002226.3	1.26	NRPS	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0001132.4	0.30	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.29	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.28	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000420.5	0.25	NRPS	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0000372.5	0.25	NRPS	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0001267.3	0.23	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0000818.5	0.21	NRPS	notoamide A	Aspergillus versicolor
BGC0002254.3	0.20	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001084.5	0.19	NRPS, other (other), terpene	notoamide A	Aspergillus sp. MF297-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002226.3	0.98	NRPS	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000372.5	0.48	NRPS	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0000420.5	0.47	NRPS	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0002071.2	0.44	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000292.4	0.43	NRPS	acetylaranotin	Aspergillus terreus NIH2624
BGC0000426.5	0.43	NRPS	sevadicin	Paenibacillus larvae
BGC0000321.4	0.43	NRPS	chaetocin	Collariella virescens

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 48062:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ASPACDRAFT_46595: Trp - X

Search NORINE for peptide: strict or relaxed

AMP-binding (18..400): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAGIVGACAK
Nearest Stachelhaus code(s):: Trp DAGIVGACAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1040..1423): X

nrpys: D-Ph-Lac

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GGFIYAAVMK
Nearest Stachelhaus code(s):: D-Ph-Lac GGFIYAAVMK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor