BGC0002226 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002226 (Aspergillus aculeatus ATCC 16872)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,indole	1	12,549	acu-dioxomorpholine B/acu-dioxomorpholine A	NRPS:Type I	100%

BGC0002226 - Region 1 - NRPS,indole

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Location: 1 - 12,549 nt. (total: 12,549 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 12,550
Label		BGC0002226

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002226	1.34	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0002444	0.62	Terpene	epoxy-Janthitrems	Epichloe sp. LpTG-3
BGC0000420	0.30	NRP	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0000372	0.24	NRP	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0001132	0.23	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001267	0.23	Terpene	lysergic acid, elymoclavine	Claviceps fusiformis
BGC0000818	0.22	NRP	notoamide A	Aspergillus versicolor
BGC0002286	0.22	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641	0.21	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002254	0.21	Polyketide	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002226	1.00	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0002444	0.64	Terpene	epoxy-Janthitrems	Epichloe sp. LpTG-3
BGC0001132	0.56	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286	0.55	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000420	0.55	NRP	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0001641	0.53	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000372	0.49	NRP	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0002242	0.49	NRP	oxepinamide D	Aspergillus ustus
BGC0000321	0.49	NRP	chaetocin	Collariella virescens
BGC0000292	0.49	NRP	acetylaranotin	Aspergillus terreus NIH2624

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 12549:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ASPACDRAFT_46595

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AMP-binding (18..400): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAGIVGACAK
Nearest Stachelhaus code(s):: Trp DAGIVGACAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1040..1423): X

nrpys: D-Ph-Lac

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GGFIYAAVMK
Nearest Stachelhaus code(s):: D-Ph-Lac GGFIYAAVMK (100% 8Å match)
Stachelhaus code match:: 100% (strong)