BGC0002242 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002242 (Aspergillus ustus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	23,805	oxepinamide D	NRPS:Type I	100%

BGC0002242 - Region 1 - NRPS

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Location: 1 - 23,805 nt. (total: 23,805 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,806
Label		BGC0002242

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002242	1.00	NRP	oxepinamide D	Aspergillus ustus
BGC0002157	0.33	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002208	0.30	NRP	oxepinamide F	Aspergillus ustus
BGC0001261	0.29	NRP	AM-toxin	Alternaria alternata
BGC0001240	0.26	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000342	0.25	NRP	enniatin	Fusarium equiseti
BGC0001132	0.25	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000313	0.25	NRP	beauvericin	Beauveria bassiana
BGC0002164	0.25	NRP	peramine	Epichloe festucae
BGC0001135	0.25	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002242	1.00	NRP	oxepinamide D	Aspergillus ustus
BGC0002157	0.66	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002208	0.64	NRP	oxepinamide F	Aspergillus ustus
BGC0001261	0.63	NRP	AM-toxin	Alternaria alternata
BGC0001240	0.60	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000342	0.59	NRP	enniatin	Fusarium equiseti
BGC0001132	0.59	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000313	0.59	NRP	beauvericin	Beauveria bassiana
BGC0002164	0.58	NRP	peramine	Epichloe festucae
BGC0001135	0.58	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 23805:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - D-X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HK57_00503

AMP-binding (229..622): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GMIFFAAGIK
Nearest Stachelhaus code(s):: Ant GALFFAAGVK (74% 8Å match); Trp GALFFAAGVK (68% 8Å match); 4clBza or 2clBza GVIILAAGIK (56% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1312..1708): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DCVVMAGPIK
Nearest Stachelhaus code(s):: Ala DMVIMAGALK (56% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (2852..3250): X

nrpys: Phe, Trp, Ph-Gly, Tyr, bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALFIVAIGK
Nearest Stachelhaus code(s):: Thr DAQTIVAIHK (53% 8Å match)
Stachelhaus code match:: 70% (weak)