BGC0002258 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002258 (Aspergillus stellatus (Emericella variecolor))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	25,000	shimalactone A/shimalactone B	PKS	100%

BGC0002258 - Region 1 - T1PKS

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Location: 1 - 25,000 nt. (total: 25,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,001
Label		BGC0002258

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002258	1.00	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0001254	0.34	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002192	0.31	Polyketide	FR901512	fungal sp. No.14919
BGC0002139	0.27	Polyketide	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0001305	0.25	Polyketide	fujikurin A, fujikurin B, fujikurin C, fujikurin D	Fusarium fujikuroi IMI 58289
BGC0001268	0.24	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0000064	0.24	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0002185	0.23	Polyketide	gregatin A	Penicillium sp.
BGC0002538	0.23	Polyketide	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0001907	0.23	Polyketide	chromane	Daldinia eschscholzii IFB-TL01

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002258	1.00	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0001254	0.67	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002192	0.65	Polyketide	FR901512	fungal sp. No.14919
BGC0002139	0.61	Polyketide	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0001305	0.59	Polyketide	fujikurin A, fujikurin B, fujikurin C, fujikurin D	Fusarium fujikuroi IMI 58289
BGC0001268	0.57	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0000064	0.57	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0002185	0.57	Polyketide	gregatin A	Penicillium sp.
BGC0002538	0.56	Polyketide	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0001907	0.56	Polyketide	chromane	Daldinia eschscholzii IFB-TL01

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 25000:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

shmA

PKS_AT (581..900): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 74.7
Methoxymalonyl-CoA: 63.0
Ethylmalonyl-CoA: 51.7
Isobutyryl-CoA: 39.0
Malonyl-CoA: 37.7
Benzoyl-CoA: 19.1
Propionyl-CoA: 14.7
trans-1,2-CPDA: 14.3
fatty_acid: 11.2
3-Methylbutyryl-CoA: 9.8
inactive: 9.0
CHC-CoA: 6.5
2-Methylbutyryl-CoA: 3.7
Acetyl-CoA: 0.0