BGC0002369 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002369 (Actinomadura rubteroloni)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,468	High	maduralactomycin A/maduralactomycin B/actinospirol A/actinospirol B	PKS

BGC0002369 - Region 1 - T2PKS

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Location: 1 - 72,468 nt. (total: 72,468 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,469
Label		BGC0002369

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

BTM25_23820: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

BTM25_23870: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BTM25_23890: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

BTM25_23910: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

BTM25_23960: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: carboxylase halogenase transferase

BTM25_23770: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

BTM25_23800: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

BTM25_23920: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: cyclase

BTM25_23830: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

BTM25_23880: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

BTM25_23840: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BTM25_23850: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002369.2	1.00	PKS	maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B	Actinomadura rubteroloni
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.81	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.75	PKS	oviedomycin	Streptomyces antibioticus
BGC0000235.5	0.61	PKS	kiamycin	Streptomyces sp. W007
BGC0000253.4	0.60	PKS	oviedomycin	Streptomyces antibioticus
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002047.2	0.56	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000221.5	0.56	PKS	erdacin	uncultured soil bacterium V167
BGC0002000.4	0.55	PKS	setomimycin	Streptomyces aurantiacus JA 4570

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002369.2	1.00	PKS	maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B	Actinomadura rubteroloni
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.81	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.75	PKS	oviedomycin	Streptomyces antibioticus
BGC0000235.5	0.61	PKS	kiamycin	Streptomyces sp. W007
BGC0000253.4	0.60	PKS	oviedomycin	Streptomyces antibioticus
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002047.2	0.56	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000221.5	0.56	PKS	erdacin	uncultured soil bacterium V167
BGC0002000.4	0.55	PKS	setomimycin	Streptomyces aurantiacus JA 4570

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72468
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 639.4; E-value: 4.5e-195)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 416 Da
acetyl-CoA_9: 458 Da

BTM25_23770: HAL (Score: 390.7; E-value: 2e-119)
BTM25_23820: OXY (Score: 559.2; E-value: 1.9e-170)
BTM25_23830: CYC C4-C17/C2-C19 (Score: 180.9; E-value: 5.4e-56)
BTM25_23840: KS (Score: 770.8; E-value: 7.3e-235)
BTM25_23850: CLF 8|9 (Score: 639.4; E-value: 4.5e-195)
BTM25_23860: ACP (Score: 113.6; E-value: 7.5e-36)
BTM25_23870: KR C9 (Score: 471.1; E-value: 2e-144)
BTM25_23880: CYC C7-C12 (Score: 469.6; E-value: 8.2e-144)
BTM25_23890: OXY (Score: 432.4; E-value: 5.6e-132)
BTM25_23960: OXY (Score: 514.6; E-value: 6.2e-157)