BGC0002431: maduramicin biosynthetic gene cluster from Actinomadura sp.
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Location: 1 - 121,610 nt. (total: 121,610 nt).
This entry is originally from NCBI GenBank MN272733.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002431
Short description maduramicin biosynthetic gene cluster from Actinomadura sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • saccharide (None)
Loci
MN272733.1
1 - 121610
via Gene expression correlated with compound production
Compounds
  • maduramicin
Species Actinomadura sp. [taxonomy]
References
Chemical products information
maduramicin Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QFU19813.1
  • madG4
 175 - 1254 (+) oxidoreductase
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    • QFU19816.1
    • madG3
    		 1291 - 2730 (-) NDP-hexose 2,3-dehydratase
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      • QFU19814.1
      • madG5
      		 2939 - 3622 (+) dTDP-4-keto-6-deoxy-D-glucose epimerase
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        • QFU19815.1
        • madG6
        		 3601 - 4371 (-) dTDP-6-deoxy-L-hexose 3-O-methyltransferase
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          • QFU19817.1
          • madG7
          		 4401 - 5396 (-) aldo/keto reductase
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            • QFU19818.1
            • madG8
            		 5719 - 6657 (+) sugar O-methyltransferase
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              • QFU19819.1
              • madR4
              		 6902 - 7603 (+) transcriptional regulator
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                • QFU19820.1
                • madT1
                		 7596 - 8516 (+) ABC transporter ATP-binding protein
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                  • QFU19821.1
                  • madT2
                  		 8513 - 10114 (+) ABC transporter permease
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                    • QFU19822.1
                    • madTE
                    		 10272 - 11183 (+) type II Thioesterase
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                      • QFU19823.1
                      • madG9
                      		 11236 - 12537 (-) glycosyltransferase
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                        • QFU19824.1
                        • madU
                        		 12779 - 13447 (+) hypothetical protein
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                          • QFU19825.1
                          • madA7
                          		 13547 - 27859 (+) PKS
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                            • QFU19826.1
                            • madA8
                            		 27915 - 34190 (+) PKS
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                              • QFU19827.1
                              • madA9
                              		 34195 - 39801 (+) PKS
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                                • QFU19828.1
                                • madO1
                                		 39871 - 41313 (+) epoxidase
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                                  • QFU19829.1
                                  • madI
                                  		 41363 - 42220 (+) epoxide hydrolase
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                                    • QFU19830.1
                                    • madO2
                                    		 42277 - 43710 (+) epoxidase
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                                      • QFU19831.1
                                      • madA10
                                      		 43707 - 46199 (+) PKS
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                                        • QFU19850.1
                                        • madP1
                                        		 46196 - 47437 (+) cytochrome P450
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                                          • QFU19832.1
                                          • madM1
                                          		 47622 - 48449 (-) methyltransferase
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                                            • QFU19833.1
                                            • madA11
                                            		 48773 - 49120 (+) ACP
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                                              • QFU19834.1
                                              • madP2
                                              		 49179 - 50519 (+) cytochrome P450
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                                                • QFU19835.1
                                                • madM2
                                                		 50522 - 51457 (+) methyltransferase
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                                                  • QFU19836.1
                                                  • madG10
                                                  		 51489 - 52838 (+) glycosyltransferase
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                                                    • QFU19837.1
                                                    • madE
                                                    		 52926 - 53819 (+) polyketide thioesterase
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                                                      • QFU19838.1
                                                      • madA6
                                                      		 53885 - 58894 (-) PKS
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                                                        • QFU19839.1
                                                        • madA5
                                                        		 58891 - 70998 (-) PKS
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                                                          • QFU19840.1
                                                          • madA4
                                                          		 71015 - 83077 (-) PKS
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                                                            • QFU19841.1
                                                            • madA3
                                                            		 83103 - 95234 (-) PKS
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                                                              • QFU19842.1
                                                              • madA2
                                                              		 95231 - 101884 (-) PKS
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                                                                • QFU19843.1
                                                                • madA1
                                                                		 101885 - 109174 (-) PKS
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                                                                  • QFU19844.1
                                                                  • madT3
                                                                  		 109324 - 110256 (+) ABC transporter ATP-binding protein
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                                                                    • QFU19845.1
                                                                    • madR1
                                                                    		 110858 - 111625 (+) transcriptional regulator
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                                                                      • QFU19846.1
                                                                      • madG2
                                                                      		 111845 - 112876 (-) dTDP-glucose 4,6-dehydratase
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                                                                        • QFU19847.1
                                                                        • madG1
                                                                        		 112873 - 113793 (-) glucose-1-phosphate thymidylyltransferase
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                                                                          • QFU19848.1
                                                                          • madR2
                                                                          		 114740 - 117637 (+) transcriptional regulator
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                                                                            • QFU19849.1
                                                                            • madR3
                                                                            		 118506 - 121295 (+) transcriptional regulator
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                                                                              Biosynthesis information

                                                                              No biosynthesis information available for this record.

                                                                              Annotation changelog

                                                                              Entry version: 2

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-10-07
                                                                              Added chemical structures for compounds: maduramicin.
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              2022-10-07
                                                                              Added NPAtlas links to compounds: maduramicin.
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 1

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-09-15
                                                                              Entry added
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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