BGC0002497: hexacosalactone A biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 131,383 nt. (total: 131,383 nt).
This entry is originally from NCBI GenBank MT994316.1, but has been modified (see Modifications tab for details).

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General
Compounds
Genes
Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0002497
Short description hexacosalactone A biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
MT994316.1
1 - 131383
via Knock-out studies
Compounds
  • hexacosalactone A
Species Streptomyces sp. [taxonomy]
References
Chemical products information
hexacosalactone A Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QQZ01610.1
  • hcl1
 1220 - 2611 (+) PucR family transcriptional regulator
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    • QQZ01611.1
    • hcl2
    		 2820 - 3626 (+) methyltransferase
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      • QQZ01612.1
      • hcl3
      		 3755 - 5215 (-) PucR family transcriptional regulator
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        • QQZ01613.1
        • hcl4
        		 5327 - 6289 (+) agmatinase
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          • QQZ01614.1
          • hcl5
          		 6282 - 7823 (+) nitrate reductase
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            • QQZ01615.1
            • hcl6
            		 7831 - 8475 (+) cyclase family protein
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              • QQZ01616.1
              • hcl7
              		 8502 - 8909 (+) ketosteroid isomerase
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                • QQZ01617.1
                • hcl8
                		 8906 - 10354 (+) gamma-aminobutyraldehyde dehydrogenase
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                  • QQZ01618.1
                  • hcl9
                  		 10443 - 10949 (+) GNAT family N-acetyltransferase
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                    • QQZ01619.1
                    • hcl10
                    		 11118 - 11900 (+) SGNH hydrolase
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                      • QQZ01620.1
                      • hcl11
                      		 11939 - 12931 (+) PHB depolymerase family esterase
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                        • QQZ01621.1
                        • hclX
                        		 13100 - 14641 (-) long-chain fatty acid--CoA ligase
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                          • QQZ01622.1
                          • hclY
                          		 14638 - 16179 (-) amide synthase
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                            • QQZ01623.1
                            • hclZ
                            		 16440 - 17687 (+) 5-aminolevulinate synthase
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                              • QQZ01624.1
                              • hcl12
                              		 17881 - 18852 (+) malonyl transferase
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                                • QQZ01625.1
                                • hcl13
                                		 18849 - 19916 (+) arylcarboxylate reductase
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                                  • QQZ01626.1
                                  • hclA
                                  		 20214 - 38417 (+) PKS
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                                    • QQZ01627.1
                                    • hclB
                                    		 38512 - 58281 (+) PKS
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                                      • QQZ01628.1
                                      • hcl3_rename1
                                      		 58283 - 69223 (+) PKS
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                                        • QQZ01629.1
                                        • hclD
                                        		 69292 - 86676 (+) PKS
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                                          • QQZ01630.1
                                          • hcl14
                                          		 86799 - 87647 (+) methyltransferase
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                                            • QQZ01631.1
                                            • hcl15
                                            		 87858 - 88700 (+) aldo/keto reductase
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                                              • QQZ01632.1
                                              • hcl16
                                              		 88834 - 89535 (+) alpha/beta hydrolase
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                                                • QQZ01633.1
                                                • hcl17
                                                		 89610 - 90305 (-) hypothetical protein
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                                                  • QQZ01634.1
                                                  • hcl18
                                                  		 90758 - 92431 (+) ABC transporter
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                                                    • QQZ01635.1
                                                    • hcl19
                                                    		 92838 - 99962 (+) PKS
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                                                      • QQZ01636.1
                                                      • hcl20
                                                      		 99959 - 104554 (+) PKS
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                                                        • QQZ01637.1
                                                        • hcl21
                                                        		 104551 - 104901 (+) acyl carrier protein
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                                                          • QQZ01638.1
                                                          • hcl22
                                                          		 104905 - 105837 (+) alpha/beta hydrolase
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                                                            • QQZ01639.1
                                                            • hcl23
                                                            		 105834 - 107174 (+) glycosyltransferase
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                                                              • QQZ01640.1
                                                              • hcl24
                                                              		 107171 - 108292 (+) glycosyltransferase
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                                                                • QQZ01641.1
                                                                • hcl25
                                                                		 108334 - 109350 (+) permease
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                                                                  • QQZ01642.1
                                                                  • hcl26
                                                                  		 109347 - 110120 (+) TIGR03943 family protein
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                                                                    • QQZ01643.1
                                                                    • hcl27
                                                                    		 110186 - 110980 (-) SDR family oxidoreductase
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                                                                      • QQZ01644.1
                                                                      • hcl28
                                                                      		 111096 - 113600 (-) glycosyl hydrolase
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                                                                        • QQZ01645.1
                                                                        • hcl29
                                                                        		 114092 - 115228 (-) amidase domain-containing protein
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                                                                          • QQZ01646.1
                                                                          • hcl30
                                                                          		 115356 - 116579 (-) cytochrome P450
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                                                                            • QQZ01647.1
                                                                            • hcl31
                                                                            		 116752 - 117360 (+) etR/AcrR family transcriptional regulator
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                                                                              • QQZ01648.1
                                                                              • hcl32
                                                                              		 117657 - 119285 (+) PucR family transcriptional regulator
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                                                                                • QQZ01649.1
                                                                                • hcl33
                                                                                		 119673 - 120701 (+) glutathionyl-hydroquinone reductase
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                                                                                  • QQZ01650.1
                                                                                  • hcl34
                                                                                  		 121488 - 122294 (+) HlyD family efflux transporter
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                                                                                    • QQZ01651.1
                                                                                    • hcl35
                                                                                    		 122429 - 124573 (+) ABC transporter
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                                                                                      • QQZ01652.1
                                                                                      • hcl36
                                                                                      		 125365 - 127440 (+) ABC transporter
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                                                                                        • QQZ01653.1
                                                                                        • hcl37
                                                                                        		 127460 - 129025 (-) MFS transporter
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                                                                                          Biosynthesis information

                                                                                          No biosynthesis information available for this record.

                                                                                          Annotation changelog

                                                                                          Entry version: 2

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2022-10-07
                                                                                          Added chemical structures for compounds: hexacosalactone A.
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          2022-10-07
                                                                                          Added NPAtlas links to compounds: hexacosalactone A.
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                          Entry version: 1

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2022-09-15
                                                                                          Entry added
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                                          Detailed domain annotation
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                                                                                          Modifications to original record
                                                                                          • renamed CDS with name hcl3 at [58282:69223](+) to hcl3_rename1 to avoid duplicates