BGC0002506: homopiloquinone biosynthetic gene cluster from Streptomyces sp. FXJ8.102
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 23,837 nt. (total: 23,837 nt).
This entry is originally from NCBI GenBank MN158712.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002506
Short description homopiloquinone biosynthetic gene cluster from Streptomyces sp. FXJ8.102
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
MN158712.1
1 - 23837
via Heterologous expression
Compounds
  • homopiloquinone
  • piloquinone
Species Streptomyces sp. FXJ8.102 [taxonomy]
References
Chemical products information
homopiloquinone Evidence:
Copy SMILES
Chemical database entries
NPAtlas
piloquinone Evidence:
Copy SMILES
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QFS19033.1
  • plqR1
 385 - 1284 (+) SARP family regulator
    copy AA seq
    copy Nt seq
    • QFS19034.1
    • plqR2
    		 1399 - 2046 (-) TetR family regulator
      copy AA seq
      copy Nt seq
      • QFS19035.1
      • plqV
      		 2151 - 3020 (-) NAD(P)-dependent oxidoreductase
        copy AA seq
        copy Nt seq
        • QFS19036.1
        • plqU
        		 3074 - 4702 (-) FAD dependent monooxygenase
          copy AA seq
          copy Nt seq
          • QFS19037.1
          • plqT
          		 4958 - 5254 (+) AknX family monooxygenase
            copy AA seq
            copy Nt seq
            • QFS19038.1
            • plqS
            		 5259 - 5699 (+) cyclase
              copy AA seq
              copy Nt seq
              • QFS19039.1
              • plqQ
              		 5739 - 6200 (+) unknown
                copy AA seq
                copy Nt seq
                • QFS19040.1
                • plqP
                		 6270 - 7037 (+) OxyM family protein
                  copy AA seq
                  copy Nt seq
                  • QFS19041.1
                  • plqO
                  		 7072 - 8145 (+) luciferase-like monooxygenase
                    copy AA seq
                    copy Nt seq
                    • QFS19042.1
                    • plqN
                    		 8237 - 9709 (-) oxidoreductase
                      copy AA seq
                      copy Nt seq
                      • QFS19043.1
                      • plqM
                      		 10044 - 11102 (+) ZhuC family acyltransferase
                        copy AA seq
                        copy Nt seq
                        • QFS19044.1
                        • plqA
                        		 11212 - 12480 (+) ketosynthase alpha subunit
                          copy AA seq
                          copy Nt seq
                          • QFS19045.1
                          • plqB
                          		 12773 - 13633 (+) ketosynthase beta subunit
                            copy AA seq
                            copy Nt seq
                            • QFS19046.1
                            • plqC
                            		 13782 - 14057 (+) acyl carrier protein
                              copy AA seq
                              copy Nt seq
                              • QFS19047.1
                              • plqD
                              		 14136 - 15239 (-) phosphotransferase
                                copy AA seq
                                copy Nt seq
                                • QFS19048.1
                                • plqE
                                		 15480 - 16217 (+) ketoreductase
                                  copy AA seq
                                  copy Nt seq
                                  • QFS19049.1
                                  • plqF
                                  		 16320 - 17066 (+) oxidoreductase
                                    copy AA seq
                                    copy Nt seq
                                    • QFS19050.1
                                    • plqG
                                    		 17300 - 17950 (-) unknown
                                      copy AA seq
                                      copy Nt seq
                                      • QFS19051.1
                                      • plqH
                                      		 18018 - 19589 (-) Alp1R family transporter
                                        copy AA seq
                                        copy Nt seq
                                        • QFS19052.1
                                        • plqI
                                        		 19864 - 20814 (+) cyclase
                                          copy AA seq
                                          copy Nt seq
                                          • QFS19053.1
                                          • plqJ
                                          		 21035 - 21976 (-) START domain family cyclase
                                            copy AA seq
                                            copy Nt seq
                                            • QFS19054.1
                                            • plqK
                                            		 22054 - 22851 (-) ketoreductase
                                              copy AA seq
                                              copy Nt seq
                                              • QFS19055.1
                                              • plqL
                                              		 23059 - 23580 (+) ActVB family FMN reductase
                                                copy AA seq
                                                copy Nt seq
                                                Biosynthesis information

                                                No biosynthesis information available for this record.

                                                Annotation changelog

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Added chemical structures for compounds: homopiloquinone.
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-10-07
                                                Added NPAtlas links to compounds: homopiloquinone.
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Entry added
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Similar known clusters from MIBiG 4.0
                                                Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                Detailed help and explanations are available here.

                                                Click on reference genes to show details of similarities to genes within the current region.
                                                Double click on a reference drawing to reverse the display of the genes.

                                                Click on an accession to open that entry in the MIBiG database.


                                                Location:

                                                Identifier
                                                Identity
                                                Coverage
                                                Detailed domain annotation
                                                Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                A domain glossary is available here, and an explanation of the visualisation is available here.
                                                Selected features only
                                                Show module domains