BGC0002512 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002512 (Brasilonema sp. CT11)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	24,923	anabaenopeptin 788/anabaenopeptin 816/anabaenopeptin 802	NRPS:Type I	100%

BGC0002512 - Region 1 - NRPS

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Location: 1 - 24,923 nt. (total: 24,923 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 24,924
Label		BGC0002512

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002512	1.00	NRP	anabaenopeptin 788, anabaenopeptin 816, anabaenopeptin 802	Brasilonema sp. CT11
BGC0001479	0.37	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001132	0.35	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002437	0.35	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0000426	0.35	NRP	sevadicin	Paenibacillus larvae
BGC0000438	0.34	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0000342	0.34	NRP	enniatin	Fusarium equiseti
BGC0001128	0.34	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000901	0.33	Other	ferrichrome	Aspergillus niger
BGC0000900	0.33	Other	ferrichrome	Aspergillus oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002512	1.00	NRP	anabaenopeptin 788, anabaenopeptin 816, anabaenopeptin 802	Brasilonema sp. CT11
BGC0001479	0.70	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001132	0.68	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002437	0.68	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0000426	0.68	NRP	sevadicin	Paenibacillus larvae
BGC0000438	0.67	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0000342	0.67	NRP	enniatin	Fusarium equiseti
BGC0001128	0.67	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000901	0.66	Other	ferrichrome	Aspergillus niger
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 24923:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - D-Lys) + (Leu) + (X - NMe-Ala) + (Phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

aptA

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AMP-binding (46..449): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGGTFK
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (85% 8Å match); Ile DAFFLGVTFK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1130..1537): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DTEDIGSVIK
Nearest Stachelhaus code(s):: Lys DTEDIGSVIK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

aptB

Search NORINE for peptide: strict or relaxed

AMP-binding (462..860): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DGLFLGAVIK
Nearest Stachelhaus code(s):: Ile DGFFLGVVYK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

aptC

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AMP-binding (511..905): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASFGGCVNK
Nearest Stachelhaus code(s):: Hph or Hty DLGFTGCVNK (79% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1563..1972): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

aptD

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AMP-binding (545..939): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTVAAVCK
Nearest Stachelhaus code(s):: Phe DAWTVAAVCK (79% 8Å match)
Stachelhaus code match:: 100% (strong)