BGC0002558 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002558 (Streptomyces sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	PKS-like,T1PKS	1	54,389	High	scopranone A/scopranone B/scopranone C	PKS

BGC0002558 - Region 1 - PKS-like,T1PKS

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Location: 1 - 54,389 nt. (total: 54,389 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 54,390
Label		BGC0002558

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

BBM95972.1: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

sprE: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

sprF: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

sprG: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

sprL: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

sprM: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

sprN: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

sprO: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

sprQ: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

sprS: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

sprT: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: transferase

sprU: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Ligases: synthase

sprA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

sprB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

sprC: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

sprH: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

sprP: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

sprR: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002558.2	1.41	PKS	scopranone A, scopranone B, scopranone C	Streptomyces sp.
BGC0001273.3	0.47	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.45	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000706.3	0.44	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001201.3	0.39	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001310.5	0.36	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000041.3	0.36	PKS	oronofacic acid	Pseudomonas syringae
BGC0001948.3	0.34	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0001276.3	0.34	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.33	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002558.2	1.00	PKS	scopranone A, scopranone B, scopranone C	Streptomyces sp.
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 54389:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal) + (pk) + (Me-ohmal)
Non-colinear ordering:: sprA + sprB + sprC

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 30825:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 5019 - 54389:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal) + (pk) + (Me-ohmal)
Non-colinear ordering:: sprA + sprB + sprC

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

sprA: mal - mmal

PKS_AT (550..840): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.7
inactive: 116.2
Methoxymalonyl-CoA: 60.0
Methylmalonyl-CoA: 45.2
Benzoyl-CoA: 25.0
Isobutyryl-CoA: 21.4
Propionyl-CoA: 20.4
Acetyl-CoA: 16.3
Ethylmalonyl-CoA: 12.0
2-Methylbutyryl-CoA: 6.6
CHC-CoA: 3.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1747..2045): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 75.0%; Malonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 155.7
Ethylmalonyl-CoA: 139.4
Methoxymalonyl-CoA: 130.1
2-Methylbutyryl-CoA: 110.4
Propionyl-CoA: 89.9
trans-1,2-CPDA: 89.3
Malonyl-CoA: 81.4
CHC-CoA: 73.9
Benzoyl-CoA: 41.8
Isobutyryl-CoA: 41.1
fatty_acid: 29.1
Acetyl-CoA: 26.8
inactive: 18.4
3-Methylbutyryl-CoA: 7.9

sprB: pk

PKS_AT (569..863): pk

ATSignature: Ethylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 181.6
Ethylmalonyl-CoA: 173.2
Methoxymalonyl-CoA: 157.2
trans-1,2-CPDA: 138.9
2-Methylbutyryl-CoA: 125.6
CHC-CoA: 114.7
Propionyl-CoA: 109.8
Malonyl-CoA: 95.1
Isobutyryl-CoA: 68.9
Acetyl-CoA: 50.5
fatty_acid: 44.4
Benzoyl-CoA: 41.0
3-Methylbutyryl-CoA: 31.5
inactive: 20.3

sprC: mmal

PKS_AT (588..884): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 145.6
Ethylmalonyl-CoA: 131.6
Methoxymalonyl-CoA: 118.2
2-Methylbutyryl-CoA: 90.3
trans-1,2-CPDA: 82.0
Propionyl-CoA: 76.1
Malonyl-CoA: 69.6
CHC-CoA: 54.1
Isobutyryl-CoA: 40.2
fatty_acid: 38.1
Benzoyl-CoA: 27.5
Acetyl-CoA: 18.8
inactive: 15.0
3-Methylbutyryl-CoA: 9.2

Link to PARAS substrate predictor