BGC0002582 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002582 (Streptomyces chrestomyceticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	7,207	guanipiperazine A/guanipiperazine B	NRPS:Type I	100%

BGC0002582 - Region 1 - NRPS-like

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Location: 1 - 7,207 nt. (total: 7,207 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,208
Label		BGC0002582

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002582	1.00	NRP	guanipiperazine A, guanipiperazine B	Streptomyces chrestomyceticus
BGC0001168	0.36	NRP	livipeptin	Streptomyces lividans 1326
BGC0001599	0.28	NRP	fragin	Burkholderia cenocepacia H111
BGC0000712	0.28	Saccharide	paromomycin	Streptomyces rimosus subsp. paromomycinus
BGC0001516	0.28	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0002602	0.28	Alkaloid	aspergillic acid	Aspergillus flavus
BGC0002278	0.26	Alkaloid, NRP	brasiliamide I, brasiliamide A, brasiliamide B, 2,2-dibenzylpiperazine, brasiliamide D	Penicillium brasilianum
BGC0000844	0.25	Other	clavulanic acid	Streptomyces clavuligerus
BGC0002127	0.21	Polyketide	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001223	0.21	Other	hydroxysporine	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002582	1.00	NRP	guanipiperazine A, guanipiperazine B	Streptomyces chrestomyceticus
BGC0001168	0.68	NRP	livipeptin	Streptomyces lividans 1326
BGC0001599	0.62	NRP	fragin	Burkholderia cenocepacia H111
BGC0000712	0.62	Saccharide	paromomycin	Streptomyces rimosus subsp. paromomycinus
BGC0001516	0.61	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0002602	0.61	Alkaloid	aspergillic acid	Aspergillus flavus
BGC0002278	0.60	Alkaloid, NRP	brasiliamide I, brasiliamide A, brasiliamide B, 2,2-dibenzylpiperazine, brasiliamide D	Penicillium brasilianum
BGC0000844	0.58	Other	clavulanic acid	Streptomyces clavuligerus
BGC0002127	0.54	Polyketide	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001223	0.53	Other	hydroxysporine	uncultured bacterium

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 7207:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

QUF98525.1

AMP-binding (36..437): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAIYSGFVVK
Nearest Stachelhaus code(s):: Leu DAWYLGNVVK (59% 8Å match); Leu or Ile DAIYLGVVLK (59% 8Å match)
Stachelhaus code match:: 70% (weak)