BGC0002591 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002591 (Streptomyces sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	HR-T2PKS,terpene-precursor	1	20,232	High	aurachin C/aurachin D/aurachin SS	PKS+terpene

BGC0002591 - Region 1 - HR-T2PKS,terpene-precursor

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Location: 1 - 20,232 nt. (total: 20,232 nt) Show pHMM detection rules used

Region on contig edge.

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
terpene-precursor: (PT_FPPS_like and not PT_HPP)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Terpene

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 20,233
Label		BGC0002591

Tailoring functions

Oxidoreductases: oxygenase

ARM20255.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

ARM20265.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Hydrolases: esterase

ARM20259.1: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase synthetase

ARM20257.1: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

ARM20258.1: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

ARM20260.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

ARM20262.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002591.2	1.91	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.
BGC0002631.2	0.41	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0002397.2	0.39	terpene	astallatene	Arabidopsis thaliana
BGC0000677.5	0.37	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001310.5	0.37	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001075.5	0.36	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0000663.5	0.35	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0001343.3	0.35	PKS	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0002400.2	0.35	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002283.2	0.34	terpene	sodorifen	Serratia plymuthica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002591.2	0.98	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0002397.2	0.52	terpene	astallatene	Arabidopsis thaliana
BGC0000677.5	0.51	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001310.5	0.50	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001075.5	0.50	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0000663.5	0.49	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0002400.2	0.49	terpene	boleracene	Brassica oleracea var. oleracea
BGC0001343.3	0.49	PKS	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0002283.2	0.48	terpene	sodorifen	Serratia plymuthica

Similar known clusters from MIBiG 4.0

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

ARM20258.1: PT_FPPS_like

Domain 1 (72 - 369): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Terpene

NRPS/PKS substrate predictions

ARM20260.1: X

AMP-binding (26..418): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GGNFVAGHIK
Nearest Stachelhaus code(s):: diOH-Bz AANFVSGAIK (38% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate