BGC0002638: misaugamycin A biosynthetic gene cluster from Streptomyces sp. WAC 00631
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Location: 604,269 - 677,424 nt. (total: 73,156 nt).
This entry is originally from NCBI GenBank QHKJ02000004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002638
Short description misaugamycin A biosynthetic gene cluster from Streptomyces sp. WAC 00631
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
QHKJ02000004.1
604269 - 677424
via Heterologous expression, Gene expression correlated with compound production
Compounds
  • misaugamycin A
  • misaugamycin B
Species Streptomyces sp. WAC 00631 [taxonomy]
References
Chemical products information
misaugamycin A Evidence:
(no structure information available)
misaugamycin B Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • DMH02_027255
  • MCC5036771.1
 604319 - 606100 (-) ABC transporter ATP-binding protein/permease
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    • DMH02_027260
    • MCC5036772.1
    		 606097 - 607968 (-) ABC transporter ATP-binding protein/permease
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      • DMH02_027265
      • MCC5036773.1
      		 608071 - 608793 (+) L,D-transpeptidase family protein
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        • DMH02_027270
        • MCC5036774.1
        		 608951 - 610894 (+) ABC transporter ATP-binding protein/permease
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          • DMH02_027275
          • MCC5036775.1
          		 610908 - 611996 (-) NAD(P)/FAD-dependent oxidoreductase
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            • DMH02_027280
            • MCC5036776.1
            		 612062 - 612484 (+) secondary thiamine-phosphate synthase enzyme YjbQ
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              • DMH02_027285
              		 612607 - 612816 (-) helix-turn-helix domain-containing protein
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                • DMH02_027290
                • MCC5036777.1
                		 612942 - 613436 (-) Lrp/AsnC family transcriptional regulator
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                  • DMH02_027295
                  • MCC5036778.1
                  		 613526 - 614866 (-) HAMP domain-containing protein
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                    • DMH02_027300
                    • MCC5036779.1
                    		 614874 - 615527 (-) response regulator transcription factor
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                      • DMH02_027305
                      • MCC5036780.1
                      		 616103 - 618949 (-) AAA family ATPase
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                        • DMH02_027310
                        • MCC5036781.1
                        		 620493 - 621488 (+) ParB N-terminal domain-containing protein
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                          • DMH02_027315
                          • MCC5036782.1
                          		 622216 - 624177 (+) ABC transporter ATP-binding protein/permease
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                            • DMH02_027320
                            		 624269 - 627124 (+) amino acid adenylation domain-containing protein
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                              • DMH02_027325
                              		 627125 - 628813 (+) condensation domain-containing protein
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                                • DMH02_027330
                                • MCC5036783.1
                                		 628859 - 632113 (+) amino acid adenylation domain-containing protein
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                                  • DMH02_027335
                                  • MCC5036784.1
                                  		 632110 - 636738 (+) amino acid adenylation domain-containing protein
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                                    • DMH02_027340
                                    • MCC5036785.1
                                    		 636774 - 650705 (+) amino acid adenylation domain-containing protein
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                                      • DMH02_027345
                                      • MCC5036786.1
                                      		 650717 - 657424 (+) amino acid adenylation domain-containing protein
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                                        • DMH02_027350
                                        • MCC5036787.1
                                        		 657421 - 657648 (+) MbtH family protein
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                                          • DMH02_027355
                                          • MCC5036788.1
                                          		 657738 - 659060 (+) cation:proton antiporter
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                                            • DMH02_027360
                                            • MCC5036789.1
                                            		 659295 - 660797 (+) tryptophan 7-halogenase
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                                              • DMH02_027365
                                              • MCC5036790.1
                                              		 660808 - 661989 (+) cytochrome P450
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                                                • DMH02_027370
                                                • MCC5036791.1
                                                		 661997 - 663229 (+) cytochrome P450
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                                                  • DMH02_027375
                                                  • MCC5036792.1
                                                  		 663280 - 663558 (+) ferredoxin
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                                                    • DMH02_027380
                                                    • MCC5036793.1
                                                    		 663600 - 664820 (-) transposase
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                                                      • DMH02_027385
                                                      • MCC5036794.1
                                                      • tnpA
                                                      		 664817 - 665239 (-) IS200/IS605 family transposase
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                                                        • DMH02_027390
                                                        • MCC5036795.1
                                                        		 665396 - 665719 (+) acyl carrier protein
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                                                          • DMH02_027395
                                                          • MCC5036796.1
                                                          		 665723 - 667102 (+) AMP-binding protein
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                                                            • DMH02_027400
                                                            • MCC5036797.1
                                                            		 667161 - 667934 (+) phosphosulfolactate synthase
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                                                              • DMH02_027405
                                                              • MCC5036798.1
                                                              		 667931 - 668335 (+) VOC family protein
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                                                                • DMH02_027410
                                                                • MCC5036799.1
                                                                		 668390 - 669463 (-) alpha-hydroxy-acid oxidizing protein
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                                                                  • DMH02_027415
                                                                  • MCC5036800.1
                                                                  • hppD
                                                                  		 669579 - 670679 (-) 4-hydroxyphenylpyruvate dioxygenase
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                                                                    • DMH02_027420
                                                                    • MCC5036801.1
                                                                    		 671061 - 672419 (+) PLP-dependent aminotransferase family protein
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                                                                      • DMH02_027425
                                                                      • MCC5036802.1
                                                                      		 672416 - 673378 (+) prephenate dehydrogenase
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                                                                        • DMH02_027430
                                                                        • MCC5036803.1
                                                                        		 673575 - 674156 (+) hypothetical protein
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                                                                          • DMH02_027435
                                                                          • MCC5036804.1
                                                                          		 674153 - 675574 (+) peptidoglycan-binding protein
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                                                                            • DMH02_027440
                                                                            • MCC5036805.1
                                                                            		 675592 - 676347 (+) ABC transporter ATP-binding protein
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                                                                              Biosynthesis information

                                                                              Biosynthetic modules

                                                                              Name
                                                                              Unk01
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              DMH02_027330
                                                                              Substrates
                                                                              4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk02
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              DMH02_027330
                                                                              Substrates
                                                                              tryptophan (evidence: Sequence-based prediction, Mass spectrometry)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk03
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              DMH02_027335
                                                                              Substrates
                                                                              4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk04
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              DMH02_027340
                                                                              Substrates
                                                                              4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk05
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              DMH02_027340
                                                                              Substrates
                                                                              4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk06
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              DMH02_027340
                                                                              Substrates
                                                                              4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk07
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              DMH02_027345
                                                                              Substrates
                                                                              4-hydroxyphenylglycine (evidence: Sequence-based prediction, Mass spectrometry)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Annotation changelog

                                                                              Entry version: 2

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-10-07
                                                                              Update chemical activity to schema version 2.11
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 1

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-09-15
                                                                              Entry added
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              2022-09-15
                                                                              Updated bioactivity data
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              2022-09-15
                                                                              Added NRP substrate specificities
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              Detailed domain annotation
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