BGC0002686: madurastatin D1 biosynthetic gene cluster from Actinomadura sp. WMMA1423
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Location: 793,880 - 907,895 nt. (total: 114,016 nt).
This entry is originally from NCBI GenBank NZ_CP041244.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002686
Short description madurastatin D1 biosynthetic gene cluster from Actinomadura sp. WMMA1423
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_CP041244.1
793880 - 907542
via
Compounds
  • madurastatin D1
  • madurastatin D2
  • (-)-Madurastatin C1
Species Actinomadura sp. WMMA1423 [taxonomy]
References
Chemical products information
madurastatin D1 Evidence:
(no structure information available)
madurastatin D2 Evidence:
(no structure information available)
(-)-Madurastatin C1 Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • FKD65_RS04195
  • WP_141576235.1
 793880 - 795058 (+) acyl-CoA dehydrogenase family protein
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    • FKD65_RS04200
    • WP_141576236.1
    		 795193 - 795402 (+) HGxxPAAW family protein
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      • FKD65_RS04205
      • WP_141576237.1
      		 795405 - 795587 (+) hypothetical protein
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        • FKD65_RS04210
        • WP_141576238.1
        		 795953 - 797068 (+) glutamate--cysteine ligase
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          • FKD65_RS04215
          • WP_141576239.1
          		 797258 - 798205 (+) sensor histidine kinase
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            • FKD65_RS04220
            • WP_240809957.1
            		 798215 - 799132 (-) phosphotransferase
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              • FKD65_RS04225
              • WP_141576241.1
              		 799303 - 799539 (-) hypothetical protein
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                • FKD65_RS04230
                • WP_141576242.1
                		 799787 - 800230 (+) DoxX family membrane protein
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                  • FKD65_RS04235
                  • WP_141576243.1
                  		 800293 - 800925 (+) GNAT family N-acetyltransferase
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                    • FKD65_RS04240
                    • WP_240810283.1
                    		 801212 - 801997 (+) SAM-dependent methyltransferase
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                      • FKD65_RS04245
                      • WP_141576245.1
                      		 802196 - 803494 (+) acyltransferase
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                        • FKD65_RS04250
                        • WP_141576246.1
                        		 803609 - 804787 (+) helix-turn-helix domain-containing protein
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                          • FKD65_RS04255
                          • WP_205718541.1
                          		 804794 - 805693 (-) alpha/beta hydrolase-fold protein
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                            • FKD65_RS04260
                            • WP_141576247.1
                            		 805690 - 806589 (-) DMT family transporter
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                              • FKD65_RS44005
                              • WP_168220944.1
                              		 806780 - 806980 (+) hypothetical protein
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                                • FKD65_RS44010
                                		 <807266 - 807556 (+) D-beta-D-heptose 1-phosphate adenosyltransferase
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                                  • FKD65_RS04270
                                  • WP_141576248.1
                                  		 807602 - 808912 (-) ABC transporter substrate-binding protein
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                                    • FKD65_RS04275
                                    • WP_205718542.1
                                    		 808830 - 810032 (-) branched-chain amino acid ABC transporter permease
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                                      • FKD65_RS04280
                                      • WP_141576249.1
                                      		 810037 - 810915 (-) branched-chain amino acid ABC transporter permease
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                                        • FKD65_RS04285
                                        • WP_141576250.1
                                        		 810915 - 811622 (-) ABC transporter ATP-binding protein
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                                          • FKD65_RS04290
                                          • WP_141576251.1
                                          		 811615 - 812394 (-) ABC transporter ATP-binding protein
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                                            • FKD65_RS04295
                                            • WP_141576252.1
                                            		 812628 - 813230 (+) TetR/AcrR family transcriptional regulator
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                                              • FKD65_RS04300
                                              • WP_240809958.1
                                              		 813265 - 814896 (-) long-chain fatty acid--CoA ligase
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                                                • FKD65_RS44745
                                                • WP_205718543.1
                                                		 815080 - 815475 (+) hypothetical protein
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                                                  • FKD65_RS04310
                                                  • WP_141576253.1
                                                  		 815508 - 816371 (+) PHB depolymerase family esterase
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                                                    • FKD65_RS04315
                                                    • WP_141576254.1
                                                    		 816433 - 816639 (-) MbtH family protein
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                                                      • FKD65_RS04320
                                                      • WP_141576255.1
                                                      		 816723 - 818018 (-) lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein
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                                                        • FKD65_RS04325
                                                        • WP_141576256.1
                                                        		 818018 - 819037 (-) iron-siderophore ABC transporter substrate-binding protein
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                                                          • FKD65_RS04330
                                                          • WP_141576257.1
                                                          		 819141 - 831182 (-) non-ribosomal peptide synthetase
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                                                            • FKD65_RS04335
                                                            • WP_240809959.1
                                                            		 831271 - 832581 (+) salicylate synthase
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                                                              • FKD65_RS45345
                                                              • WP_240809960.1
                                                              		 832926 - 833387 (+) zinc finger domain-containing protein
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                                                                • FKD65_RS04345
                                                                • WP_141576258.1
                                                                		 833606 - 835048 (+) toxin glutamine deamidase domain-containing protein
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                                                                  • FKD65_RS04350
                                                                  • WP_141576259.1
                                                                  		 835075 - 835374 (+) hypothetical protein
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                                                                    • FKD65_RS04355
                                                                    • WP_141576260.1
                                                                    		 835417 - 836034 (+) exonuclease
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                                                                      • FKD65_RS04360
                                                                      • WP_205718545.1
                                                                      		 836110 - 836310 (+) isochorismatase family protein
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                                                                        • FKD65_RS04365
                                                                        • WP_141576261.1
                                                                        		 836780 - 837358 (+) hypothetical protein
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                                                                          • FKD65_RS04370
                                                                          • WP_205718546.1
                                                                          		 837401 - 837946 (-) alpha-ketoglutarate-dependent dioxygenase AlkB
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                                                                            • FKD65_RS04375
                                                                            • WP_141576263.1
                                                                            		 838997 - 840658 (+) TROVE domain-containing protein
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                                                                              • FKD65_RS04380
                                                                              • WP_141576264.1
                                                                              		 840696 - 841313 (-) GyrI-like domain-containing protein
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                                                                                • FKD65_RS04385
                                                                                • WP_141576265.1
                                                                                		 841300 - 841893 (-) PadR family transcriptional regulator
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                                                                                  • FKD65_RS04390
                                                                                  • WP_141576266.1
                                                                                  		 842468 - 843235 (+) hypothetical protein
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                                                                                    • FKD65_RS04395
                                                                                    • WP_141576267.1
                                                                                    		 843366 - 845969 (-) hypothetical protein
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                                                                                      • FKD65_RS04400
                                                                                      • WP_141576268.1
                                                                                      		 845974 - 848061 (-) DEAD/DEAH box helicase
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                                                                                        • FKD65_RS04405
                                                                                        • WP_141576269.1
                                                                                        • brxD
                                                                                        		 848061 - 849410 (-) BREX system ATP-binding protein BrxD
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                                                                                          • FKD65_RS04410
                                                                                          • WP_168220945.1
                                                                                          • pglZ
                                                                                          		 849410 - 852049 (-) BREX-2 system phosphatase PglZ
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                                                                                            • FKD65_RS04415
                                                                                            • WP_141576271.1
                                                                                            		 852046 - 855678 (-) phage resistance protein
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                                                                                              • FKD65_RS04420
                                                                                              • WP_141576272.1
                                                                                              • pglX
                                                                                              		 855721 - 859266 (-) BREX-2 system adenine-specific DNA-methyltransferase PglX
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                                                                                                • FKD65_RS04425
                                                                                                • WP_141576273.1
                                                                                                		 859540 - 860187 (+) hypothetical protein
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                                                                                                  • FKD65_RS04430
                                                                                                  • WP_141576274.1
                                                                                                  		 860209 - 860775 (-) hypothetical protein
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                                                                                                    • FKD65_RS04440
                                                                                                    • WP_141576275.1
                                                                                                    		 861528 - 862514 (-) hypothetical protein
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                                                                                                      • FKD65_RS04445
                                                                                                      • WP_205718547.1
                                                                                                      		 862817 - 863251 (-) hypothetical protein
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                                                                                                        • FKD65_RS04450
                                                                                                        • WP_141576276.1
                                                                                                        		 863244 - 864230 (-) hypothetical protein
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                                                                                                          • FKD65_RS44015
                                                                                                          • WP_168220946.1
                                                                                                          		 864716 - 865471 (-) TIGR04222 domain-containing membrane protein
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                                                                                                            • FKD65_RS44020
                                                                                                            • WP_168220947.1
                                                                                                            		 865741 - 867270 (+) hypothetical protein
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                                                                                                              • FKD65_RS04460
                                                                                                              • WP_141576277.1
                                                                                                              		 867257 - 867706 (+) hypothetical protein
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                                                                                                                • FKD65_RS04465
                                                                                                                • WP_141576278.1
                                                                                                                		 867755 - 868240 (+) hypothetical protein
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                                                                                                                  • FKD65_RS04470
                                                                                                                  • WP_240809961.1
                                                                                                                  		 869166 - 869987 (+) helix-turn-helix transcriptional regulator
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                                                                                                                    • FKD65_RS04475
                                                                                                                    • WP_141576279.1
                                                                                                                    		 869984 - 870175 (+) DUF397 domain-containing protein
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                                                                                                                      • FKD65_RS04480
                                                                                                                      • WP_141576280.1
                                                                                                                      • pglX
                                                                                                                      		 870308 - 873910 (-) BREX-2 system adenine-specific DNA-methyltransferase PglX
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                                                                                                                        • FKD65_RS04485
                                                                                                                        • WP_168220948.1
                                                                                                                        • pglW
                                                                                                                        		 873907 - 878211 (-) BREX system serine/threonine kinase PglW
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                                                                                                                          • FKD65_RS04490
                                                                                                                          • WP_240809962.1
                                                                                                                          		 878470 - 880194 (+) DUF262 domain-containing protein
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                                                                                                                            • FKD65_RS04495
                                                                                                                            • WP_141576283.1
                                                                                                                            		 880191 - 881159 (+) hypothetical protein
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                                                                                                                              • FKD65_RS04500
                                                                                                                              • WP_141576284.1
                                                                                                                              		 881235 - 882803 (-) AMP-binding protein
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                                                                                                                                • FKD65_RS04505
                                                                                                                                • WP_141586355.1
                                                                                                                                		 882806 - 883207 (-) aspartate 1-decarboxylase
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                                                                                                                                  • FKD65_RS04510
                                                                                                                                  • WP_141576285.1
                                                                                                                                  • entS
                                                                                                                                  		 883280 - 884524 (+) enterobactin transporter EntS
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                                                                                                                                    • FKD65_RS04515
                                                                                                                                    • WP_141576286.1
                                                                                                                                    		 884533 - 887895 (-) non-ribosomal peptide synthetase
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                                                                                                                                      • FKD65_RS04520
                                                                                                                                      • WP_141576287.1
                                                                                                                                      		 887948 - 888964 (-) iron chelate uptake ABC transporter family permease subunit
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                                                                                                                                        • FKD65_RS04525
                                                                                                                                        • WP_141576288.1
                                                                                                                                        		 888961 - 890010 (-) iron chelate uptake ABC transporter family permease subunit
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                                                                                                                                          • FKD65_RS45350
                                                                                                                                          		 890224 - >890328 (+) TetR/AcrR family transcriptional regulator
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                                                                                                                                            • FKD65_RS45355
                                                                                                                                            • WP_240810284.1
                                                                                                                                            		 890500 - 890814 (+) hypothetical protein
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                                                                                                                                              • FKD65_RS04535
                                                                                                                                              • WP_141576290.1
                                                                                                                                              		 890807 - 891709 (+) ABC transporter ATP-binding protein
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                                                                                                                                                • FKD65_RS04540
                                                                                                                                                • WP_141576291.1
                                                                                                                                                		 891706 - 893343 (+) ABC transporter permease
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                                                                                                                                                  • FKD65_RS04545
                                                                                                                                                  • WP_141576292.1
                                                                                                                                                  		 893448 - 893843 (+) STAS domain-containing protein
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                                                                                                                                                    • FKD65_RS44025
                                                                                                                                                    • WP_168220949.1
                                                                                                                                                    		 893887 - 895653 (-) sensor histidine kinase
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                                                                                                                                                      • FKD65_RS04555
                                                                                                                                                      • WP_141576293.1
                                                                                                                                                      		 895954 - 896628 (-) response regulator transcription factor
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                                                                                                                                                        • FKD65_RS04560
                                                                                                                                                        • WP_141576294.1
                                                                                                                                                        		 896619 - 898433 (-) histidine kinase
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                                                                                                                                                          • FKD65_RS04565
                                                                                                                                                          • WP_240809963.1
                                                                                                                                                          • dinB
                                                                                                                                                          		 898600 - 899775 (-) DNA polymerase IV
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                                                                                                                                                            • FKD65_RS04570
                                                                                                                                                            • WP_240809964.1
                                                                                                                                                            		 899917 - 902841 (-) glycoside hydrolase family 48 protein
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                                                                                                                                                              • FKD65_RS04575
                                                                                                                                                              • WP_141576297.1
                                                                                                                                                              		 902951 - 903988 (-) LacI family DNA-binding transcriptional regulator
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                                                                                                                                                                • FKD65_RS04580
                                                                                                                                                                • WP_141576298.1
                                                                                                                                                                		 904282 - 905772 (+) cellulase family glycosylhydrolase
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                                                                                                                                                                  • FKD65_RS04585
                                                                                                                                                                  		 905816 - 907542 (+) glycoside hydrolase family 6 protein
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                                                                                                                                                                    Biosynthesis information

                                                                                                                                                                    No biosynthesis information available for this record.

                                                                                                                                                                    Annotation changelog

                                                                                                                                                                    Entry version: 2

                                                                                                                                                                    Date
                                                                                                                                                                    Changes
                                                                                                                                                                    Submitters
                                                                                                                                                                    Reviewers
                                                                                                                                                                    2024-08-12
                                                                                                                                                                    MIBiG v4 annotathon
                                                                                                                                                                    • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                    Entry version: 1

                                                                                                                                                                    Date
                                                                                                                                                                    Changes
                                                                                                                                                                    Submitters
                                                                                                                                                                    Reviewers
                                                                                                                                                                    2022-09-15
                                                                                                                                                                    Entry added
                                                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                                                                                                                    Detailed domain annotation
                                                                                                                                                                    Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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