BGC0002726 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002726 (Bipolaris sorokiniana (Cochliobolus sativus))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	73,894	High	4-chloropinselin/pinselin/chloromonilinic acid B/chloromonilinic acid D/4-hydroxyvertixanthone	PKS

BGC0002726 - Region 1 - T1PKS

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Location: 1 - 73,894 nt. (total: 73,894 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 73,895
Label		BGC0002726

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

QCF41194.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

QCF41208.1: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 63.00%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase halogenase methyltransferase

QCF41200.1: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

QCF41201.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

QCF41205.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

QCF41206.1: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

QCF41202.1: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 67.80%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydrolase

QCF41202.1: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 67.80%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: dehydrogenase

QCF41208.1: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 63.00%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002726.2	0.96	PKS	4-chloropinselin, pinselin, chloromonilinic acid B, chloromonilinic acid D, 4-hydroxyvertixanthone	Bipolaris sorokiniana
BGC0002608.2	0.79	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000013.3	0.69	PKS	alternariol	Aspergillus nidulans FGSC A4
BGC0001284.4	0.68	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002726.2	1.00	PKS	4-chloropinselin, pinselin, chloromonilinic acid B, chloromonilinic acid D, 4-hydroxyvertixanthone	Bipolaris sorokiniana
BGC0002608.2	0.79	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000013.3	0.69	PKS	alternariol	Aspergillus nidulans FGSC A4
BGC0001284.4	0.68	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 27464 - 73101:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

QCF41201.1: mal

PKS_AT (948..1247): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 91.7
inactive: 57.7
Methylmalonyl-CoA: 51.1
Methoxymalonyl-CoA: 48.9
Propionyl-CoA: 40.9
Benzoyl-CoA: 25.6
Isobutyryl-CoA: 23.6
2-Methylbutyryl-CoA: 21.5
CHC-CoA: 19.2
3-Methylbutyryl-CoA: 17.2
Ethylmalonyl-CoA: 17.1
fatty_acid: 15.2
Acetyl-CoA: 14.6
trans-1,2-CPDA: 11.4

Link to PARAS substrate predictor