BGC0002729 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002729 (Neurospora crassa OR74A)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	27,499	neurosporin A	Polyketide	60%

BGC0002729 - Region 1 - T1PKS

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Location: 1 - 27,499 nt. (total: 27,499 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 27,500
Label		BGC0002729

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001697.1	0.53	Polyketide	neurosporin A	Neurospora crassa OR74A
BGC0001858.1	0.27	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001280.1	0.27	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.27	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001068.1	0.24	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001141.1	0.24	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001909.1	0.24	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001254.1	0.22	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0000003.1	0.22	Polyketide	AF-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001697.1	0.81	Polyketide	neurosporin A	Neurospora crassa OR74A
BGC0001858.1	0.61	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001280.1	0.60	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.60	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001141.1	0.57	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001909.1	0.57	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000056.1	0.56	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001254.1	0.55	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0000003.1	0.54	Polyketide	AF-toxin	Alternaria alternata

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 27499:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

NCU02918

PKS_AT (579..885): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 62.5%; Isobutyryl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 61.6
Methoxymalonyl-CoA: 55.8
Malonyl-CoA: 33.1
Ethylmalonyl-CoA: 28.4
Propionyl-CoA: 20.4
Isobutyryl-CoA: 14.6
fatty_acid: 9.2
CHC-CoA: 8.9
Benzoyl-CoA: 8.9
trans-1,2-CPDA: 0.0
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0