BGC0000045 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000045 (Aspergillus terreus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	31,000	trans-resorcylide	Polyketide	66%

BGC0000045 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 31,000 nt. (total: 31,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 31,001
Label		BGC0000045

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000045.1	0.67	Polyketide	dehydrocurvularin	Aspergillus terreus
BGC0001246.1	0.25	Polyketide	trans-resorcylide	Sarocladium zeae
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000046.1	0.22	Polyketide	depudecin	Alternaria brassicicola
BGC0001254.1	0.22	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0001124.1	0.22	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001258.1	0.21	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.1	0.21	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001265.1	0.21	Polyketide	melanin	Bipolaris oryzae
BGC0001284.1	0.21	Terpene	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000045.1	0.87	Polyketide	dehydrocurvularin	Aspergillus terreus
BGC0001246.1	0.59	Polyketide	trans-resorcylide	Sarocladium zeae
BGC0000056.1	0.56	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000046.1	0.55	Polyketide	depudecin	Alternaria brassicicola
BGC0001254.1	0.55	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0001124.1	0.54	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001258.1	0.54	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.1	0.54	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001265.1	0.54	Polyketide	melanin	Bipolaris oryzae
BGC0001284.1	0.54	Terpene	alternariol	Parastagonospora nodorum SN15

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 31000:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: curS1 + curS2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

curS2

PKS_AT (896..1189): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 122.7
inactive: 81.1
Methoxymalonyl-CoA: 61.6
Methylmalonyl-CoA: 53.4
Isobutyryl-CoA: 33.7
2-Methylbutyryl-CoA: 23.2
Benzoyl-CoA: 22.6
Propionyl-CoA: 21.0
Acetyl-CoA: 20.9
CHC-CoA: 17.2
Ethylmalonyl-CoA: 15.3
trans-1,2-CPDA: 13.1
3-Methylbutyryl-CoA: 12.5
fatty_acid: 0.0

curS1

PKS_AT (551..872): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; 2-Methylbutyryl-CoA: 66.7%; Methylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 85.7
Methoxymalonyl-CoA: 69.9
Malonyl-CoA: 66.8
Ethylmalonyl-CoA: 49.1
Isobutyryl-CoA: 38.9
Benzoyl-CoA: 38.0
Propionyl-CoA: 36.4
2-Methylbutyryl-CoA: 24.7
fatty_acid: 18.8
CHC-CoA: 18.5
trans-1,2-CPDA: 14.4
Acetyl-CoA: 13.5
3-Methylbutyryl-CoA: 13.2
inactive: 0.0