BGC0000058 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000058 (Streptomyces graminofaciens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	74,321	meridamycin	NRP + Polyketide	10%

BGC0000058 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 74,321 nt. (total: 74,321 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 74,322
Label		BGC0000058

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000058.1	0.84	Polyketide	FD-891	Streptomyces graminofaciens
BGC0000041.1	0.34	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.33	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.31	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001273.1	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000018.1	0.30	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001266.1	0.30	Polyketide	grayanic acid	Cladonia grayi
BGC0000059.1	0.29	Polyketide	filipin	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000080.1	0.29	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000058.1	0.95	Polyketide	FD-891	Streptomyces graminofaciens
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.66	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.65	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000018.1	0.63	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001276.1	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001266.1	0.63	Polyketide	grayanic acid	Cladonia grayi
BGC0000059.1	0.63	Polyketide	filipin	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000080.1	0.63	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 74321:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ohmal - pk - ohmal - ccmal) + (Me-redmal - ohmal - ccmal) + (redmal) + (ccmal - Me-ccmal) + (Me-ccmal - Me-ccmal)
Non-colinear ordering:: gfsA + gfsB + gfsC + gfsD + gfsE

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

gfsA

PKS_AT (563..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.4
inactive: 89.7
Methoxymalonyl-CoA: 55.4
Methylmalonyl-CoA: 46.7
Acetyl-CoA: 19.7
Propionyl-CoA: 19.1
Benzoyl-CoA: 16.3
trans-1,2-CPDA: 12.8
Isobutyryl-CoA: 12.7
Ethylmalonyl-CoA: 9.8
fatty_acid: 8.5
CHC-CoA: 6.9
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (1563..1865): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.6
Ethylmalonyl-CoA: 188.5
Methoxymalonyl-CoA: 176.6
2-Methylbutyryl-CoA: 153.8
trans-1,2-CPDA: 117.3
Malonyl-CoA: 116.3
Propionyl-CoA: 113.0
CHC-CoA: 107.8
Isobutyryl-CoA: 78.6
Benzoyl-CoA: 62.6
Acetyl-CoA: 51.4
inactive: 44.6
3-Methylbutyryl-CoA: 42.0
fatty_acid: 22.4

PKS_AT (3069..3366): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 217.0
Methylmalonyl-CoA: 212.0
Methoxymalonyl-CoA: 170.7
2-Methylbutyryl-CoA: 155.5
trans-1,2-CPDA: 120.2
Propionyl-CoA: 112.7
CHC-CoA: 111.5
Malonyl-CoA: 84.8
Isobutyryl-CoA: 61.8
Benzoyl-CoA: 55.6
Acetyl-CoA: 46.8
3-Methylbutyryl-CoA: 34.4
fatty_acid: 28.6
inactive: 23.8

PKS_AT (4628..4931): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.4
inactive: 89.7
Methoxymalonyl-CoA: 55.4
Methylmalonyl-CoA: 46.7
Acetyl-CoA: 19.7
Propionyl-CoA: 19.1
Benzoyl-CoA: 16.3
trans-1,2-CPDA: 12.8
Isobutyryl-CoA: 12.7
Ethylmalonyl-CoA: 9.8
fatty_acid: 8.5
CHC-CoA: 6.9
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (6189..6489): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.8
inactive: 94.0
Methoxymalonyl-CoA: 67.2
Methylmalonyl-CoA: 57.8
Propionyl-CoA: 40.3
Isobutyryl-CoA: 32.9
Ethylmalonyl-CoA: 21.2
Benzoyl-CoA: 17.5
Acetyl-CoA: 17.3
CHC-CoA: 11.9
2-Methylbutyryl-CoA: 9.6
fatty_acid: 9.2
trans-1,2-CPDA: 4.6
3-Methylbutyryl-CoA: 0.0

gfsB

PKS_AT (611..909): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.5
Ethylmalonyl-CoA: 210.7
Methoxymalonyl-CoA: 178.2
2-Methylbutyryl-CoA: 172.5
trans-1,2-CPDA: 146.2
Propionyl-CoA: 118.8
CHC-CoA: 109.5
Malonyl-CoA: 97.0
Isobutyryl-CoA: 94.9
Benzoyl-CoA: 81.2
3-Methylbutyryl-CoA: 50.3
Acetyl-CoA: 44.7
fatty_acid: 32.7
inactive: 30.9

PKS_AT (2709..3012): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.4
inactive: 94.8
Methoxymalonyl-CoA: 59.4
Methylmalonyl-CoA: 53.9
Isobutyryl-CoA: 27.8
Propionyl-CoA: 20.4
Acetyl-CoA: 18.1
Benzoyl-CoA: 17.2
Ethylmalonyl-CoA: 10.9
fatty_acid: 8.8
CHC-CoA: 4.7
2-Methylbutyryl-CoA: 4.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4279..4579): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.8
inactive: 87.7
Methoxymalonyl-CoA: 70.0
Methylmalonyl-CoA: 58.0
Ethylmalonyl-CoA: 23.3
Propionyl-CoA: 22.9
Benzoyl-CoA: 18.7
Isobutyryl-CoA: 15.9
CHC-CoA: 14.5
Acetyl-CoA: 11.5
fatty_acid: 9.9
2-Methylbutyryl-CoA: 7.2
trans-1,2-CPDA: 5.4
3-Methylbutyryl-CoA: 0.0

gfsC

PKS_AT (564..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.8
inactive: 94.0
Methoxymalonyl-CoA: 67.2
Methylmalonyl-CoA: 57.8
Propionyl-CoA: 40.3
Isobutyryl-CoA: 32.9
Ethylmalonyl-CoA: 21.2
Benzoyl-CoA: 17.5
Acetyl-CoA: 17.3
CHC-CoA: 11.9
2-Methylbutyryl-CoA: 9.6
fatty_acid: 9.2
trans-1,2-CPDA: 4.6
3-Methylbutyryl-CoA: 0.0

gfsD

PKS_AT (572..872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 181.1
inactive: 88.3
Methoxymalonyl-CoA: 67.3
Methylmalonyl-CoA: 56.7
Propionyl-CoA: 25.1
Ethylmalonyl-CoA: 22.1
Benzoyl-CoA: 18.7
Isobutyryl-CoA: 15.4
CHC-CoA: 14.5
Acetyl-CoA: 12.2
fatty_acid: 11.3
trans-1,2-CPDA: 9.1
2-Methylbutyryl-CoA: 7.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (2290..2616): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.3
Ethylmalonyl-CoA: 194.9
Methoxymalonyl-CoA: 160.1
2-Methylbutyryl-CoA: 149.4
trans-1,2-CPDA: 121.6
CHC-CoA: 109.1
Propionyl-CoA: 104.8
Malonyl-CoA: 101.7
Isobutyryl-CoA: 90.3
Benzoyl-CoA: 68.1
Acetyl-CoA: 56.4
inactive: 39.4
3-Methylbutyryl-CoA: 29.3
fatty_acid: 26.3

gfsE

PKS_AT (582..875): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.6
Ethylmalonyl-CoA: 205.7
Methoxymalonyl-CoA: 169.0
2-Methylbutyryl-CoA: 142.0
Propionyl-CoA: 123.9
trans-1,2-CPDA: 116.0
Malonyl-CoA: 109.5
CHC-CoA: 107.5
Isobutyryl-CoA: 73.9
Acetyl-CoA: 59.5
Benzoyl-CoA: 58.3
fatty_acid: 50.9
3-Methylbutyryl-CoA: 41.2
inactive: 31.1

PKS_AT (2284..2585): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.9
Ethylmalonyl-CoA: 184.3
Methoxymalonyl-CoA: 168.2
2-Methylbutyryl-CoA: 152.0
trans-1,2-CPDA: 122.9
Malonyl-CoA: 112.2
CHC-CoA: 111.3
Propionyl-CoA: 109.0
Isobutyryl-CoA: 86.0
Benzoyl-CoA: 68.7
Acetyl-CoA: 48.2
inactive: 47.5
3-Methylbutyryl-CoA: 40.2
fatty_acid: 33.9