BGC0000075 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000075 (Streptomyces sp. LZ35)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	76,600	divergolide A / divergolide B / divergolide C / divergolide D	Polyketide:Modular type I	58%

BGC0000075 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 76,600 nt. (total: 76,600 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 76,601
Label		BGC0000075

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000075.1	1.55	Polyketide	hygrocin A, hygrocin B	Streptomyces sp. LZ35
BGC0000041.1	0.85	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.69	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.60	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001273.1	0.60	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.60	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.59	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.1	0.59	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001284.1	0.57	Terpene	alternariol	Parastagonospora nodorum SN15
BGC0000156.1	0.57	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000075.1	0.97	Polyketide	hygrocin A, hygrocin B	Streptomyces sp. LZ35
BGC0000041.1	0.74	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.66	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001164.1	0.64	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001504.1	0.63	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.1	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001304.1	0.63	Polyketide	aflavarin	Aspergillus flavus NRRL3357

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 75399:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal - mal - ohmal) + (redemal) + (ccmal) + (Me-redmal) + (Me-mal - ccmal)
Non-colinear ordering:: hgcA + hgcB + hgcC + hgcD + hgcE

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

hgcA

CAL_domain (57..465): pk

minowa: AHBA

Prediction, score:

AHBA: 405.5
shikimic_acid: 245.1
fatty_acid: 0.0
NH2: 0.0
Acetyl-CoA: 0.0

PKS_AT (1660..1958): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.0
Ethylmalonyl-CoA: 195.5
Methoxymalonyl-CoA: 158.5
2-Methylbutyryl-CoA: 124.7
trans-1,2-CPDA: 110.2
Propionyl-CoA: 107.6
Malonyl-CoA: 88.2
CHC-CoA: 83.4
Isobutyryl-CoA: 74.4
Benzoyl-CoA: 64.5
Acetyl-CoA: 50.9
fatty_acid: 37.9
inactive: 33.0
3-Methylbutyryl-CoA: 17.2

PKS_AT (3380..3683): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.7
inactive: 131.5
Methoxymalonyl-CoA: 74.5
Methylmalonyl-CoA: 51.0
Propionyl-CoA: 37.1
Benzoyl-CoA: 24.3
Isobutyryl-CoA: 20.7
Ethylmalonyl-CoA: 20.4
Acetyl-CoA: 20.2
2-Methylbutyryl-CoA: 13.1
CHC-CoA: 8.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4420..4718): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.4
inactive: 108.2
Methoxymalonyl-CoA: 58.2
Methylmalonyl-CoA: 51.2
Propionyl-CoA: 30.4
Acetyl-CoA: 22.8
Isobutyryl-CoA: 17.5
Ethylmalonyl-CoA: 13.4
fatty_acid: 10.2
trans-1,2-CPDA: 7.3
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

hgcB

PKS_AT (620..917): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 83.3%; Methylmalonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 186.1
Methylmalonyl-CoA: 181.4
Methoxymalonyl-CoA: 142.8
2-Methylbutyryl-CoA: 112.2
Propionyl-CoA: 106.8
trans-1,2-CPDA: 95.8
CHC-CoA: 86.8
Malonyl-CoA: 77.2
Isobutyryl-CoA: 77.2
Benzoyl-CoA: 53.9
Acetyl-CoA: 42.0
fatty_acid: 35.2
3-Methylbutyryl-CoA: 34.6
inactive: 26.5

hgcC

PKS_AT (570..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.5
inactive: 112.8
Methoxymalonyl-CoA: 59.5
Methylmalonyl-CoA: 49.4
Propionyl-CoA: 28.9
Isobutyryl-CoA: 24.3
Acetyl-CoA: 21.8
Ethylmalonyl-CoA: 16.4
fatty_acid: 11.8
CHC-CoA: 3.8
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

hgcD

PKS_AT (571..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.7
Ethylmalonyl-CoA: 180.3
Methoxymalonyl-CoA: 145.7
2-Methylbutyryl-CoA: 114.8
Propionyl-CoA: 98.5
trans-1,2-CPDA: 95.4
Malonyl-CoA: 83.2
CHC-CoA: 82.3
Isobutyryl-CoA: 64.2
Benzoyl-CoA: 59.4
Acetyl-CoA: 40.2
fatty_acid: 39.3
inactive: 29.0
3-Methylbutyryl-CoA: 21.2

hgcE

PKS_AT (573..872): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.5
Ethylmalonyl-CoA: 171.9
Methoxymalonyl-CoA: 148.6
2-Methylbutyryl-CoA: 114.0
Propionyl-CoA: 99.9
trans-1,2-CPDA: 94.2
Malonyl-CoA: 80.6
CHC-CoA: 80.5
Benzoyl-CoA: 62.9
Isobutyryl-CoA: 62.1
Acetyl-CoA: 39.3
fatty_acid: 37.2
inactive: 22.6
3-Methylbutyryl-CoA: 21.8

PKS_AT (1593..1891): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.5
inactive: 111.1
Methoxymalonyl-CoA: 58.6
Methylmalonyl-CoA: 53.4
Propionyl-CoA: 30.4
Acetyl-CoA: 20.1
Isobutyryl-CoA: 18.3
Ethylmalonyl-CoA: 14.2
fatty_acid: 9.2
CHC-CoA: 5.7
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0