BGC0000085 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000085 (Streptomyces rochei)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	68,094	erythromycin A / erythromycin B / erythromycin C / erythromycin D	Polyketide:Modular type I + Saccharide:Hybrid/tailoring	65%

BGC0000085 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 68,094 nt. (total: 68,094 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 68,095
Label		BGC0000085

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000085.1	0.80	Polyketide	lankamycin	Streptomyces rochei
BGC0001661.1	0.38	Polyketide	mayamycin	Streptomyces sp.
BGC0000263.1	0.35	Polyketide	ravidomycin	Streptomyces ravidus
BGC0000041.1	0.34	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000226.1	0.34	Polyketide	gilvocarcin V	Streptomyces griseoflavus
BGC0002031.1	0.32	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000715.1	0.32	Saccharide	actinospectacin	Streptomyces spectabilis
BGC0000716.1	0.31	Saccharide	spectinomycin	Streptomyces netropsis
BGC0001280.1	0.28	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.28	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000085.1	0.94	Polyketide	lankamycin	Streptomyces rochei
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002031.1	0.66	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001280.1	0.62	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.62	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001892.1	0.61	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0000067.1	0.61	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.60	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000907.1	0.60	Other	lincomycin	Streptomyces lincolnensis
BGC0000903.1	0.59	Other	fluorometabolite	Streptomyces cattleya

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 63010:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ccmal - Me-ohmal) + (Me-ohmal - Me-redmal) + (Me-ohmal - Me-ohmal)
Non-colinear ordering:: lkmAI + lkmAII + lkmAIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

lkmAIII

PKS_AT (576..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.0
Ethylmalonyl-CoA: 184.6
Methoxymalonyl-CoA: 168.3
2-Methylbutyryl-CoA: 142.4
Propionyl-CoA: 110.4
trans-1,2-CPDA: 108.7
CHC-CoA: 106.3
Malonyl-CoA: 98.0
Isobutyryl-CoA: 69.2
Benzoyl-CoA: 61.8
Acetyl-CoA: 44.0
fatty_acid: 40.3
inactive: 28.3
3-Methylbutyryl-CoA: 26.0

PKS_AT (2079..2375): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.6
Ethylmalonyl-CoA: 206.0
Methoxymalonyl-CoA: 178.0
2-Methylbutyryl-CoA: 160.7
trans-1,2-CPDA: 124.9
Malonyl-CoA: 122.2
Propionyl-CoA: 119.9
CHC-CoA: 103.0
Isobutyryl-CoA: 89.6
3-Methylbutyryl-CoA: 51.3
Benzoyl-CoA: 47.4
Acetyl-CoA: 41.2
inactive: 36.3
fatty_acid: 22.9

lkmAII

PKS_AT (562..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.2
Ethylmalonyl-CoA: 200.0
Methoxymalonyl-CoA: 178.0
2-Methylbutyryl-CoA: 150.8
trans-1,2-CPDA: 126.4
Propionyl-CoA: 118.6
Malonyl-CoA: 115.9
CHC-CoA: 102.2
Isobutyryl-CoA: 101.7
Benzoyl-CoA: 65.1
Acetyl-CoA: 60.4
inactive: 48.2
fatty_acid: 37.0
3-Methylbutyryl-CoA: 30.1

PKS_AT (2063..2360): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.9
Ethylmalonyl-CoA: 194.2
Methoxymalonyl-CoA: 168.6
2-Methylbutyryl-CoA: 145.2
Propionyl-CoA: 111.7
trans-1,2-CPDA: 104.1
Malonyl-CoA: 90.5
Isobutyryl-CoA: 89.5
CHC-CoA: 82.8
Benzoyl-CoA: 62.8
3-Methylbutyryl-CoA: 61.4
Acetyl-CoA: 52.5
inactive: 34.9
fatty_acid: 33.2

lkmAI

PKS_AT (108..405): pk

ATSignature: 2-Methylbutyryl-CoA

Top 3 matches:: 2-Methylbutyryl-CoA: 100.0%; Propionyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%

minowa: 2-Methylbutyryl-CoA

Prediction, score:

2-Methylbutyryl-CoA: 257.4
Propionyl-CoA: 151.9
Methylmalonyl-CoA: 135.3
Ethylmalonyl-CoA: 108.1
Methoxymalonyl-CoA: 104.8
CHC-CoA: 80.6
Malonyl-CoA: 75.2
trans-1,2-CPDA: 71.5
Isobutyryl-CoA: 41.7
Acetyl-CoA: 33.5
Benzoyl-CoA: 33.1
fatty_acid: 26.7
inactive: 25.4
3-Methylbutyryl-CoA: 21.6

PKS_AT (1126..1432): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.7
Ethylmalonyl-CoA: 208.6
Methoxymalonyl-CoA: 172.0
2-Methylbutyryl-CoA: 133.3
trans-1,2-CPDA: 124.0
Propionyl-CoA: 112.4
Malonyl-CoA: 105.6
CHC-CoA: 97.5
Isobutyryl-CoA: 73.5
fatty_acid: 61.7
Benzoyl-CoA: 59.6
Acetyl-CoA: 44.9
3-Methylbutyryl-CoA: 27.8
inactive: 20.6

PKS_AT (2630..2922): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.5
Ethylmalonyl-CoA: 188.2
Methoxymalonyl-CoA: 162.0
2-Methylbutyryl-CoA: 133.8
trans-1,2-CPDA: 115.2
CHC-CoA: 102.8
Propionyl-CoA: 95.8
Malonyl-CoA: 94.5
Isobutyryl-CoA: 73.9
Benzoyl-CoA: 43.9
3-Methylbutyryl-CoA: 41.9
Acetyl-CoA: 37.5
inactive: 21.2
fatty_acid: 18.6