BGC0000134 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000134 (Pochonia chlamydosporia (Metacordyceps chlamydosporia))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	31,332	hypothemycin	Polyketide	22%

BGC0000134 - Region 1 - T1PKS

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Location: 1 - 31,332 nt. (total: 31,332 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 31,333
Label		BGC0000134

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000134.1	0.67	Polyketide	radicicol	Pochonia chlamydosporia
BGC0001858.1	0.32	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000046.1	0.32	Polyketide	depudecin	Alternaria brassicicola
BGC0001909.1	0.31	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001068.1	0.29	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000676.1	0.24	Terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001969.1	0.22	Terpene	asperterpenoid A	Talaromyces wortmannii
BGC0001124.1	0.21	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001266.1	0.21	Polyketide	grayanic acid	Cladonia grayi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000134.1	0.87	Polyketide	radicicol	Pochonia chlamydosporia
BGC0001858.1	0.66	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000046.1	0.65	Polyketide	depudecin	Alternaria brassicicola
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001068.1	0.63	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000676.1	0.57	Terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0000056.1	0.56	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001969.1	0.55	Terpene	asperterpenoid A	Talaromyces wortmannii
BGC0001124.1	0.54	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001266.1	0.54	Polyketide	grayanic acid	Cladonia grayi

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 31332:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: Rdc5 + Rdc1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

Rdc1

PKS_AT (913..1209): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 95.8
Methoxymalonyl-CoA: 62.5
inactive: 58.9
Methylmalonyl-CoA: 48.6
Isobutyryl-CoA: 43.4
Benzoyl-CoA: 30.7
Propionyl-CoA: 25.6
2-Methylbutyryl-CoA: 23.9
Acetyl-CoA: 22.7
Ethylmalonyl-CoA: 21.9
CHC-CoA: 20.6
fatty_acid: 20.5
3-Methylbutyryl-CoA: 19.0
trans-1,2-CPDA: 17.1

Rdc5

PKS_AT (550..862): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; 2-Methylbutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 91.4
Methoxymalonyl-CoA: 79.3
Malonyl-CoA: 61.7
Ethylmalonyl-CoA: 60.3
Isobutyryl-CoA: 53.5
Benzoyl-CoA: 48.1
Propionyl-CoA: 30.6
2-Methylbutyryl-CoA: 27.8
CHC-CoA: 26.3
trans-1,2-CPDA: 25.5
3-Methylbutyryl-CoA: 17.9
fatty_acid: 16.8
inactive: 15.4
Acetyl-CoA: 7.0