BGC0001034 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001034 (Sorangium cellulosum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	61,485	thaxteramide A1 / thaxteramide A2 / thaxteramide B1 / thaxteramide B2	NRP	13%

BGC0001034 - Region 1 - NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 61,485 nt. (total: 61,485 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 61,486
Label		BGC0001034

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001034.1	1.36	NRP, Polyketide	pellasoren	Sorangium cellulosum
BGC0000041.1	0.62	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000003.1	0.55	Polyketide	AF-toxin	Alternaria alternata
BGC0002057.1	0.54	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0001858.1	0.50	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001235.1	0.50	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001068.1	0.49	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000056.1	0.48	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000067.1	0.48	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001909.1	0.46	Polyketide	strobilurin	Strobilurus tenacellus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001034.1	0.95	NRP, Polyketide	pellasoren	Sorangium cellulosum
BGC0000041.1	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000003.1	0.62	Polyketide	AF-toxin	Alternaria alternata
BGC0002057.1	0.61	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0001235.1	0.60	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001283.1	0.60	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001504.1	0.60	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001858.1	0.59	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000067.1	0.59	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 61485:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ala) + (Me-ccmal) + (Me-ccmal) + (pk - Me-redmal) + (Me-ccmal) + (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

pelG

PKS_AT (27..355): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 149.7
inactive: 91.1
Methoxymalonyl-CoA: 74.7
Methylmalonyl-CoA: 52.2
2-Methylbutyryl-CoA: 39.2
Propionyl-CoA: 38.6
Ethylmalonyl-CoA: 33.6
Isobutyryl-CoA: 18.4
3-Methylbutyryl-CoA: 18.0
CHC-CoA: 14.9
Benzoyl-CoA: 12.4
trans-1,2-CPDA: 10.1
Acetyl-CoA: 8.3
fatty_acid: 0.0

pelA

Search NORINE for peptide: strict or relaxed

PKS_AT (617..911): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Malonyl-CoA: 70.8%; Propionyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 136.8
Methoxymalonyl-CoA: 109.1
Ethylmalonyl-CoA: 108.3
Isobutyryl-CoA: 99.3
Benzoyl-CoA: 76.0
Malonyl-CoA: 70.3
Acetyl-CoA: 56.7
2-Methylbutyryl-CoA: 54.0
Propionyl-CoA: 52.1
trans-1,2-CPDA: 51.4
fatty_acid: 44.7
CHC-CoA: 37.8
3-Methylbutyryl-CoA: 27.4
inactive: 16.0

PKS_AT (1058..1355): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Ethylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 163.8
Ethylmalonyl-CoA: 135.2
Methoxymalonyl-CoA: 124.7
Malonyl-CoA: 105.6
Benzoyl-CoA: 102.7
Isobutyryl-CoA: 101.3
2-Methylbutyryl-CoA: 93.1
Propionyl-CoA: 76.1
trans-1,2-CPDA: 74.2
Acetyl-CoA: 66.9
CHC-CoA: 45.4
3-Methylbutyryl-CoA: 42.1
inactive: 37.2
fatty_acid: 31.1

AMP-binding (2861..3253): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DvFvNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 80% (moderate)

pelB

PKS_AT (555..852): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 83.3%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 180.2
Ethylmalonyl-CoA: 150.4
Methoxymalonyl-CoA: 138.2
Benzoyl-CoA: 114.0
Isobutyryl-CoA: 105.5
trans-1,2-CPDA: 100.6
Malonyl-CoA: 89.8
2-Methylbutyryl-CoA: 76.7
Propionyl-CoA: 72.4
Acetyl-CoA: 64.1
3-Methylbutyryl-CoA: 46.9
CHC-CoA: 45.7
fatty_acid: 23.5
inactive: 20.9

pelC

PKS_AT (561..857): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 182.6
Ethylmalonyl-CoA: 155.0
Methoxymalonyl-CoA: 142.4
Isobutyryl-CoA: 115.6
Benzoyl-CoA: 113.7
Malonyl-CoA: 96.6
trans-1,2-CPDA: 89.3
Acetyl-CoA: 83.3
2-Methylbutyryl-CoA: 81.1
Propionyl-CoA: 70.1
3-Methylbutyryl-CoA: 60.7
CHC-CoA: 44.3
inactive: 26.9
fatty_acid: 25.0

pelD

PKS_AT (574..871): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; Methylmalonyl-CoA: 70.8%; Propionyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 125.8
Malonyl-CoA: 124.2
Methoxymalonyl-CoA: 113.6
Isobutyryl-CoA: 97.0
Ethylmalonyl-CoA: 91.0
inactive: 68.7
2-Methylbutyryl-CoA: 60.6
Propionyl-CoA: 57.4
Benzoyl-CoA: 50.5
trans-1,2-CPDA: 49.8
Acetyl-CoA: 45.7
3-Methylbutyryl-CoA: 34.6
CHC-CoA: 27.1
fatty_acid: 22.5

PKS_AT (2352..2649): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 83.3%; Ethylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 176.6
Ethylmalonyl-CoA: 145.7
Methoxymalonyl-CoA: 129.4
Isobutyryl-CoA: 109.6
Benzoyl-CoA: 102.5
Malonyl-CoA: 93.7
trans-1,2-CPDA: 84.4
2-Methylbutyryl-CoA: 80.7
Propionyl-CoA: 72.4
Acetyl-CoA: 66.8
3-Methylbutyryl-CoA: 52.9
CHC-CoA: 37.5
fatty_acid: 32.1
inactive: 18.0

pelE

PKS_AT (557..854): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 83.3%; Ethylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 179.6
Ethylmalonyl-CoA: 146.1
Methoxymalonyl-CoA: 133.1
Isobutyryl-CoA: 108.5
Benzoyl-CoA: 102.7
Malonyl-CoA: 95.3
trans-1,2-CPDA: 89.8
2-Methylbutyryl-CoA: 87.4
Propionyl-CoA: 76.4
Acetyl-CoA: 74.9
3-Methylbutyryl-CoA: 53.3
CHC-CoA: 42.9
fatty_acid: 27.8
inactive: 16.6

pelF

PKS_AT (576..873): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 83.3%; Ethylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 178.5
Ethylmalonyl-CoA: 151.2
Methoxymalonyl-CoA: 134.7
Isobutyryl-CoA: 108.0
Benzoyl-CoA: 105.3
2-Methylbutyryl-CoA: 89.3
Malonyl-CoA: 88.8
trans-1,2-CPDA: 81.8
Acetyl-CoA: 76.1
Propionyl-CoA: 73.4
3-Methylbutyryl-CoA: 52.6
CHC-CoA: 38.0
fatty_acid: 30.8
inactive: 17.2