BGC0001065 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001065 (Streptomyces chromofuscus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	53,036	megalomicin A / megalomicin B / megalomicin C1 / megalomicin C2	Polyketide	15%

BGC0001065 - Region 1 - T1PKS

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Location: 1 - 53,036 nt. (total: 53,036 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 53,037
Label		BGC0001065

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001065.1	0.49	Polyketide	herboxidiene	Streptomyces chromofuscus
BGC0000041.1	0.39	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.37	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.31	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001854.1	0.30	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001273.1	0.29	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001304.1	0.29	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0000156.1	0.29	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001275.1	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001065.1	0.78	Polyketide	herboxidiene	Streptomyces chromofuscus
BGC0000041.1	0.71	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.69	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.64	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001854.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001304.1	0.63	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0000156.1	0.63	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 53036:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - pk - pk - pk) + (ccmal - Me-ccmal - pk - redmal) + (ccmal)
Non-colinear ordering:: herB + herC + herD

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

herB

PKS_AT (514..802): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.4
Ethylmalonyl-CoA: 208.8
Methoxymalonyl-CoA: 171.7
2-Methylbutyryl-CoA: 154.4
trans-1,2-CPDA: 151.8
Propionyl-CoA: 120.5
CHC-CoA: 119.7
Malonyl-CoA: 99.7
Isobutyryl-CoA: 76.5
Benzoyl-CoA: 57.1
Acetyl-CoA: 46.4
3-Methylbutyryl-CoA: 39.5
fatty_acid: 34.5
inactive: 27.9

PKS_AT (1531..1838): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 212.4
Methylmalonyl-CoA: 206.9
Methoxymalonyl-CoA: 166.1
2-Methylbutyryl-CoA: 144.1
Propionyl-CoA: 119.2
trans-1,2-CPDA: 118.0
CHC-CoA: 107.1
Malonyl-CoA: 95.0
Isobutyryl-CoA: 82.7
Benzoyl-CoA: 76.9
Acetyl-CoA: 57.3
3-Methylbutyryl-CoA: 52.4
fatty_acid: 40.2
inactive: 19.9

PKS_AT (3017..3310): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.9
Methylmalonyl-CoA: 213.7
Methoxymalonyl-CoA: 169.9
2-Methylbutyryl-CoA: 149.6
trans-1,2-CPDA: 120.1
CHC-CoA: 101.0
Malonyl-CoA: 97.4
Propionyl-CoA: 94.1
Benzoyl-CoA: 67.4
Isobutyryl-CoA: 59.1
Acetyl-CoA: 46.2
fatty_acid: 39.8
3-Methylbutyryl-CoA: 32.3
inactive: 20.0

PKS_AT (4804..5090): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 221.2
Methylmalonyl-CoA: 214.6
Methoxymalonyl-CoA: 178.8
2-Methylbutyryl-CoA: 171.0
trans-1,2-CPDA: 121.3
Propionyl-CoA: 117.4
CHC-CoA: 109.9
Malonyl-CoA: 102.2
Isobutyryl-CoA: 87.6
Benzoyl-CoA: 71.7
Acetyl-CoA: 48.0
3-Methylbutyryl-CoA: 41.7
fatty_acid: 30.4
inactive: 26.9

herC

PKS_AT (528..812): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.6
inactive: 79.7
Methoxymalonyl-CoA: 77.0
Methylmalonyl-CoA: 76.6
Ethylmalonyl-CoA: 50.7
Isobutyryl-CoA: 36.5
Propionyl-CoA: 26.6
Acetyl-CoA: 22.4
trans-1,2-CPDA: 21.0
CHC-CoA: 20.7
Benzoyl-CoA: 14.9
fatty_acid: 12.3
2-Methylbutyryl-CoA: 9.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2268..2560): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.5
Ethylmalonyl-CoA: 202.0
Methoxymalonyl-CoA: 169.0
2-Methylbutyryl-CoA: 147.9
Propionyl-CoA: 121.3
trans-1,2-CPDA: 118.3
Malonyl-CoA: 112.9
CHC-CoA: 103.1
Isobutyryl-CoA: 92.5
Benzoyl-CoA: 64.7
fatty_acid: 43.3
Acetyl-CoA: 40.5
inactive: 34.4
3-Methylbutyryl-CoA: 21.1

PKS_AT (4005..4300): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.9
Methylmalonyl-CoA: 214.4
Methoxymalonyl-CoA: 178.2
2-Methylbutyryl-CoA: 146.3
trans-1,2-CPDA: 130.4
Propionyl-CoA: 119.3
CHC-CoA: 100.1
Malonyl-CoA: 87.7
Isobutyryl-CoA: 81.2
Benzoyl-CoA: 62.4
Acetyl-CoA: 56.2
3-Methylbutyryl-CoA: 42.0
fatty_acid: 35.7
inactive: 26.3

PKS_AT (5541..5839): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.9
inactive: 92.6
Methoxymalonyl-CoA: 65.4
Methylmalonyl-CoA: 60.7
Propionyl-CoA: 46.0
Isobutyryl-CoA: 29.5
Acetyl-CoA: 26.8
2-Methylbutyryl-CoA: 26.8
Ethylmalonyl-CoA: 24.0
Benzoyl-CoA: 20.4
CHC-CoA: 17.0
trans-1,2-CPDA: 11.6
fatty_acid: 10.2
3-Methylbutyryl-CoA: 0.0

herD

PKS_AT (568..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.1
Methoxymalonyl-CoA: 91.3
inactive: 86.3
Methylmalonyl-CoA: 79.1
Isobutyryl-CoA: 48.1
Ethylmalonyl-CoA: 42.9
Propionyl-CoA: 38.6
2-Methylbutyryl-CoA: 30.4
Benzoyl-CoA: 26.3
Acetyl-CoA: 23.0
CHC-CoA: 22.1
fatty_acid: 12.5
trans-1,2-CPDA: 6.1
3-Methylbutyryl-CoA: 0.0