BGC0001329 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001329 (Streptomyces lilacinus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	36,804	rakicidin A / rakicidin B	NRP:Cyclic depsipeptide + Polyketide:Modular type I	66%

BGC0001329 - Region 1 - NRPS,T1PKS

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Location: 1 - 36,804 nt. (total: 36,804 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 36,805
Label		BGC0001329

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001329.1	1.62	NRP, Polyketide	rakicidin D	Streptomyces lilacinus
BGC0000979.1	0.77	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.77	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000375.1	0.72	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.69	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000900.1	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0001249.1	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000876.1	0.63	Other	neopolyoxin C	Streptomyces tendae
BGC0000348.1	0.63	NRP	ergovaline	Epichloe festucae var. lolii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001329.1	0.93	NRP, Polyketide	rakicidin D	Streptomyces lilacinus
BGC0000979.1	0.71	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.71	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000375.1	0.69	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000900.1	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0001249.1	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0000876.1	0.65	Other	neopolyoxin C	Streptomyces tendae
BGC0000348.1	0.65	NRP	ergovaline	Epichloe festucae var. lolii

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 36804:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal) + (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_orf3

PKS_AT (560..857): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.7
inactive: 110.9
Methylmalonyl-CoA: 82.9
Methoxymalonyl-CoA: 80.3
Propionyl-CoA: 66.8
2-Methylbutyryl-CoA: 55.9
Isobutyryl-CoA: 53.0
Ethylmalonyl-CoA: 50.9
CHC-CoA: 49.2
Acetyl-CoA: 44.9
Benzoyl-CoA: 25.5
fatty_acid: 25.4
trans-1,2-CPDA: 23.2
3-Methylbutyryl-CoA: 18.7

ctg1_orf4

Search NORINE for peptide: strict or relaxed

AMP-binding (493..1041): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: xxxVpGAxxK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 40% (weak)

ctg1_orf13

Search NORINE for peptide: strict or relaxed

AMP-binding (176..554): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: gtErLGL--K
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 50% (weak)

ctg1_orf18

Search NORINE for peptide: strict or relaxed

AMP-binding (28..307): X

NRPSPredictor2: asp, asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: asp, asn
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLpKIaEiGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 70% (weak)